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Biomedical subjects

A K Ventura

Publications and source records attributed to A K Ventura.

At least 19 recordsLinked to original sources
PubMed1978

Influenza vaccination in renal transplant recipients.

Renal transplant recipients receiving immunosuppressive therapy are prone to major pulmonary infections. Development of influenza virus infection may lead to renal allograft damage or rejection. These patients should therefore be protected against influenza viruses by vaccination. A satisfactory antibody response was found in 12 (60%) of 20 renal transplant recipients vaccinated. Among 15 control subjects, the antibody response was satisfactory in all participants (100%). Factors that might play a role in suppression of antibody response include use of immunosuppressive drugs and renal allograft function. Immunization is safe and does not appear to affect renal allograft function.

Adolescent↗
PubMed1976

Endemic dengue virus infection in Hispaniola. I. Haiti.

Antibodies to group B arbovirus were common among coastal populations in the Haitian part of the Caribbean island of Hispaniola. Antibodies were present in 43% of children one to five years old; prevalence in older persons increased with age. In nine asymptomatic persons serodiagnostic changes indicative of group B arbovirus were detected during six of twelve consecutive months. In port cities where antibodies were common in children, Aedes aegypti indices of 50%-70% were observed; in contrast, no A. aegypti mosquitoes were found in an inland village in which children lacked denjue hemagglutination-inhibiting antibodes. Between 1969 and 1971, dengue 2 virus was isolated from 11 persons with episodic febrile illnesses, although no epidemic was apparent. These findings indicate that dengue virus infection was endemic in Haiti during the period of the study.

Adolescent↗
PubMed1975

Placental passage of antibodies to Dengue virus in persons living in a region of hyperendemic Dengue virus infection.

Maternal and umbilical cord levels of antibodies to dengue 2 and 3 viruses were compared in 54 matched pairs of specimens from subjects in the Dominican Republic. Dengue infection appeared to be hyperendemic; pregnant women experienced a 6% weekly infection rate. Titers of antibody to dengue 2 and 3 viruses were considerably higher in cord sera than in maternal sera (P smaller than 0.001 and P smaller 0.01, respectively), especially when maternal levels were low. When maternal and cord sera were compared at equal titers of dengue 2 virus, heterotypic antibodies to dengue 1 and St. Louis encephalitis viruses were higher in the cord. These findings could not be directly related to the higher levels of IgG found in cord sera or to the presence of elevated concentrations of IgM. It is concluded that antibody with increased cross-reactivity preferentially crosses the placenta. The presence of such cross-reactive antibody does not appear to sensitize infants to dengue hemorrhagic fever/shock syndrome.

Adolescent↗
PubMed1975

Clinical evaluation of a new measles-mumps-rubella combined live virus vaccine in the Dominican Republic.

Over 900 children were enrolled in a double-blind placebo-controlled clinical study of measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) trivalent vaccine. The trivalent vaccine caused about the same degree of reactivity as is generally associated with the Schwarz strain measles vaccine. Paired sera from triplesusceptible vaccinees had seroconversion rates of 99% for measles, 94% for mumps, and 93% for rubella. The results of this study show that this trivalent vaccine is as well tolerated and as effective as its component vaccines.

Child↗