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Biomedical subjects

A K Thomas

Publications and source records attributed to A K Thomas.

At least 37 records · Page 2Linked to original sources
PubMed1983

Menstrual pattern and fertility after treatment for anovulatory infertility.

Sixty-four patients who had been treated for anovulatory infertility and subsequently conceived were reviewed. Information was obtained on subsequent menstrual pattern, contraception used, treatment required to achieve a further pregnancy and the interval to any such pregnancy. Almost half the group had regular cycles following delivery but 2 patients had a recurrence of post oral contraceptive amenorrhoea. Most patients conceived without treatment within 2 years of the initial pregnancy but 10 again required ovulation induction. It is concluded that there is no long-term irreversible suppression of hypothalamic function in this group of patients and, once a pregnancy has been achieved, the prognosis for future fertility without therapy is good.

Anovulation↗
PubMed1980

Infertility: a review of 291 infertile couples over eight years.

Two hundred and ninety-one infertile couples were studied over an 8-year period. Anovulation was the most common cause of infertility, being the causative factor in half of the patients. Ovulation induction with clomiphene or cyclic hormone therapy readily achieved pregnancy in the majority of these patients. The distribution of other etiologic factors was fairly uniform, but treatment was much less successful. Thorough evaluation of both partners is advised both for treatment purposes and as a more accurate guide to the prognosis for conception. Furthermore, even in the presence of oligospermia, ovulation induction may be successful in achieving a pregnancy.

Anovulation↗
PubMed1976

Hairy legs.

Explore the source record for details and available documents.

Cyproterone↗
PubMed1975

Intranasal betamethasone valerate in the treatment of seasonal rhinitis.

Betamethasone valerate aerosol given in doses of 100 mug into each nostril twice daily was compared with a placebo in a double-blind, cross-over trial involving thirty patients with seasonal rhinitis. Patients recorded symptoms of eye irritation and watering, sneezing, rhinorrhoea, and nasal blockage, on a diary card. Analysis of the symptom scores showed that nasal symptoms were significantly better on betamethasone valerate than on placebo (P less than 0.01) and that nasal blockage in particular was improved (P less than 0.001). The patients' preference was significantly in favour of the active compound (p less than 0.02) and no side-effects were noted. It is concluded that betamethasone valerate offers a safe and effective form of treatment for seasonal rhinitis.

Administration, Intranasal↗
PubMed1975

Antibacterial activity of some newly synthesized azaphenanthrene and diazachrysene compounds.

Four newly synthesized azaphenanthrene compounds viz., 7,8,9,10-Tetrahydro-7-oxo-2-methoxy-benzo(c) phenathridine; 7,8,9,10-Tetrahydro -7-oxo-benzo(c) phenanthridine-2-[1-6-methoxy-1-naphthylimino)-methyl]cyclohexane-1,3-dione and 2-[1-(1-naphthyli; mino)-methyl]cyclohexane-1,3 dione and two diazachrysene compounds viz., 1,5-Diazachrysene and 2,5-Diazachrysese were screened for their antibacterial potency against a large number of bacterial strains. The antibacterial activity which to a varying degree was shown to be related to the aza, methoxy and keto groups, in the case of the Azaphenanthrene compounds, however, it was related to the position of the nitrogen atom in the ring in the case of Diazachrysene compounds.

Anti-Bacterial Agents↗