Search PubMed⌕ Search

Biomedical subjects

A K Pendse

Publications and source records attributed to A K Pendse.

At least 19 recordsLinked to original sources
PubMed1992

Effect of dietary salt (NaCl) supplementation on urinary profile of guinea pigs (Cavia porcellus).

Sodium chloride supplementation (120 mg/kg of body weight/day) for 12 days increased the urinary excretion of calcium from 91.6 +/- 9.0 to 159.4 +/- 16.0 mumol/day and of sulphate from 266.8 +/- 24.5 to 1176.9 +/- 87.2 mumol/day in guinea pigs. The stone risk due to increased urinary calcium excretion could possibly be counterbalanced by increasing urinary sulphate excretion. High salt intake, thus, could not increase the risk of stone formation.

Animals↗
PubMed1990

Zinc, copper and manganese in serum, urine and stones.

Serum zinc, copper and manganese levels were estimated in normal subjects (NS) and stone formers (SF). There was no significant difference in the serum levels of Zn, Cu, and Mn in NS and SF, the values being 101.5 +/- 35.1 micrograms% and 94.3 +/- 45.6 for Zn; 91.75 +/- 27.0 micrograms% and 88.5 +/- 34.1 for Cu; and 87.0 +/- 36.7 micrograms% and 79.6 +/- 35.5 for Mn, respectively. Zinc excretion was relatively high in NS (790.08 +/- 172.88 micrograms/dl) as compared to other populations and was significantly higher in SF (1154.92 +/- 290.17 micrograms%, p less than 0.001). Copper and manganese excretions in SF were significantly lower than in NS (p less than 0.001). Zinc was present in substantial quantities in renal (2.52 +/- 3.98 g%), ureteric (0.75 +/- 0.51 g%) and vesical (1.71 +/- 3.20 g%) stones. Manganese was present in traces in all the stones and copper in two-thirds of the stones.

Copper↗
PubMed1990

Hashimoto's thyroiditis--a clinical review.

Hashimoto's thyroiditis constituted 5.15% of total thyroid disorders examined from January 1983 to July 1987. Females were predominant sufferers. Average age of patients was 41.14 years. Functionally 10 patients were euthyroid, while hyperthyroidism was present in 4 cases. Its preoperative diagnosis was not possible in any of the case. All patients were subjected to surgery and postoperative thyroxine supplement.

Adult↗
PubMed1989

Interdependence of urinary factors in calcareous bladder stone patients.

Twenty-four-hour urinary excretion of calcium, oxalic acid, inorganic phosphorus, magnesium and citric acid was examined in fifty-nine stone formers with bladder stones. Hypercalciuria and hyperoxaluria were present in 18.6% and 44.1%, respectively, while 11.9% of patients had both abnormalities. Hypomagnesuria and hypocitraturia were present in 67.8% and 69.5%, respectively, while 45.7% had both of these abnormalities. Normal urine chemistry in respect of parameters studied was observed only in 1.7% of cases. In 15.2% one risk factor was present, while 83.1% had two or more risk factors. "Path" analysis of the urinary parameters directly related to calcium lithiasis showed that magnesium and oxalic acid have substantial influence on calcium excretion, whereas citric acid had none. The influence of phosphorus did not provide any consistent trend.

Calcium↗
PubMed1988

Urinary biochemical profile of patients with ureteric calculi in Jodhpur region (north western India).

Urine chemistry of 42 normal subjects (NS) and 59 ureteric stone formers (SF) from Jodhpur region of Rajasthan, India is presented. Twenty four hour urinary levels of calcium, oxalic acid and uromucoids were significantly higher and levels of magnesium, citric acid and inorganic phosphorus were significantly lower in SF as compared to NS. No significant difference was observed in the uric acid, sodium and potassium levels in the two groups. Significant correlation was observed between calcium and magnesium; calcium and oxalic acid; calcium and citric acid; magnesium and oxalic acid; and oxalic acid and citric acid in NS on the basis of mmol/l but not on the basis of mmol/24 h. Calcium and oxalic acid correlation was uninfluenced by magnesium and citric acid levels. The log of risk factor index (RI) was higher (p less than 0.001) in SF (-1.652) as compared to NS (-2.103). The log of ion activity product (IAP) was also higher (p less than 0.001) in SF (-3.192 X 10(-3)) than in NS (-2.914 X 10(-1)). Based on RI and IAP, a scale has been devised for the prediction of the risk of stone formation and recurrence.

Adult↗
PubMed1987

Sodium is neither a risk nor a protective factor in urolithiasis?

The effect of changes in urinary sodium, induced by dietary manipulation in normal subjects (NS) and in stone formers (SF) was studied by observing crytalluria qualitatively and by determining calcium, oxalate and phosphate crystallization quantitatively in an experimental model. In SF the calcium crystallization was significantly higher than in NS at all the three levels of urinary sodium studied. However, no difference was observed in oxalate and phosphate crystallization rates between these two groups. Calcium and oxalate (p less than 0.05) and oxalate and phosphate (p less than 0.001) were found to be correlated in NS but were non-significant in SF. The wide changes in the urinary sodium induced by dietary changes did not influence the crystallization rate of calcium, nor of oxalate and phosphate in NS as well as in SF. The results suggested that a sodium intake with lower and upper limits of 124 mg and 6,009 mg respectively did not act as "inhibitor" of crystallization rate nor did it induce hypercalciuria severe enough to pose a "risk" of stone formation. The results did not suggest that a high urinary sodium increases the solubility of calcium phosphate.

Calcium↗
PubMed1986

The etiology of urolithiasis in Udaipur (western part of India).

Fifty-two cases of urinary tract calculus disease were investigated for dietary habits, routine chemical and microscopic urinalysis, bacterial culture, quantitative analysis of 24 h urine sample and qualitative analysis of the stones. 54 out of the 56 stones analysed were of mixed type. Magnesium ammonium phosphate was present in 78.2% stones. Dietary habits revealed principal dependence on cereals, lack of animal proteins, consumption of oxalate rich vegetables and widespread consumption of tea. Urinary tract infection was present in 63.7% of the cases. Significant calcium oxalate crystalluria (2+ to 4+) was present in 34.6% of the cases. Hyperoxaluria, hypercalciuria associated with hyperoxaluria-lower excretion of magnesium and citric acid were important urinary risk factors in the local population. These observations strongly suggest the multifactorial etiology of stone disease in this region. Imbalanced nutrition and urinary tract infection were the principal risk factors for urolithiasis in this study.

Calcium↗
PubMed1982

Testicular dracunculosis--a distinct clinical entity.

Testicular involvement in dracunculosis is extremely rare, although intrascrotal abscesses do occur in this infestation. Two cases of testicular abscess are reported. In both cases the guinea worm had penetrated the tunica albuginea to be lodged in the testicular as well as the paratesticular tissue. Dracunculosis should be included in the differential diagnosis of testicular swellings in areas where it is endemic.

Abscess↗