Biomedical subjects

A K Pedersen

Publications and source records attributed to A K Pedersen.

At least 37 records · Page 2Linked to original sources

PubMed1999

Programming a fixed long atrioventricular delay is not effective in preventing ventricular pacing in patients with sick sinus syndrome.

AIM: Most patients with sick sinus syndrome (SSS) and normal atrioventricular (AV) conduction receive dual chamber (DDDR) pacemakers. Programming a long AV delay has been proposed to avoid ventricular pacing. The present study aimed to evaluate ventricular stimulation in SSS patients with DDDR pacemakers with a long AV delay. METHODS AND RESULTS: Thirty eight patients treated with DDDR pacemakers with a fixed long AV delay (300 ms) were studied. Data from the pacemaker event recorder were retrieved after 3 months and every year after implantation. Ten patients underwent 24 h Holter recording. Mean follow-up was 11.9 +/- 8.3 months. Median daily number of paced events in the ventricle was 2659 (25th-75th percentiles: 775-21 315) with a large inter-individual variation. The proportion of paced events in the ventricle correlated weakly with the baseline PQ interval (Spearman's rho 0.331, P = 0.043). In 12/38 patients the mean daily number of paced events in the ventricle exceeded 10,000. During 24 h Holter recording, pacemaker arrhythmias caused by repetitive retrograde atrioventricular conduction, known as VA (ventriculoatrial) conduction, occurred in five out of 10 patients. CONCLUSION: DDDR pacing with a fixed long AV delay is inefficient in reducing ventricular pacing in one third of patients and is associated with a high risk of arrhythmias caused by repetitive retrograde AV conduction, and therefore cannot be recommended for general use in SSS patients.

Aged↗

PubMed1999

Arterial thromboembolism in patients with sick sinus syndrome: prediction from pacing mode, atrial fibrillation, and echocardiographic findings.

OBJECTIVE: To evaluate whether thromboembolism in sick sinus syndrome can be predicted by pacing mode, atrial fibrillation, or echocardiographic findings. METHODS: Patients were randomised to single chamber atrial (n = 110) or ventricular (n = 115) pacing. They were divided into subgroups with and without brady-tachy syndrome at time of randomisation. The occurrence of atrial fibrillation and thromboembolism during follow up were investigated and compared with echocardiographic findings. RESULTS: The annual risk of thromboembolism was 5.8% in patients with brady-tachy syndrome randomised to ventricular pacing, 3.2% in patients without brady-tachy syndrome randomised to ventricular pacing, 3% in patients with brady-tachy syndrome randomised to atrial pacing, and 1.5% in patients without brady-tachy syndrome randomised to atrial pacing. In atrial paced patients without brady-tachy syndrome at randomisation and without atrial fibrillation during follow up, the annual risk of thromboembolism was 1.4%. Left atrial size measured by M mode echocardiography was of no value in predicting thromboembolism. CONCLUSIONS: Arterial thromboembolism in patients with sick sinus syndrome is very common and is associated primarily with brady-tachy syndrome at randomisation and with ventricular pacing. The risk of thromboembolism is small in atrial paced patients in whom atrial fibrillation has never been documented.

Aged↗

PubMed1998

Atrioventricular conduction during long-term follow-up of patients with sick sinus syndrome.

BACKGROUND: It has been claimed that patients with sick sinus syndrome have an increased risk of developing AV block, but this has never been assessed prospectively. The aim of the present study was to evaluate in a prospective trial AV conduction during the long-term follow-up of patients with sick sinus syndrome. METHODS: Two hundred twenty-five consecutive patients with sick sinus syndrome and intact AV conduction were randomized to undergo single-chamber atrial pacing (110 patients) or single-chamber ventricular pacing (115 patients). Follow-up after 3 months and then yearly included measurement of the PQ interval and, in patients with atrial pacemakers, determination of the atrial stimulus-Q intervals at pacing rates of 100 and 120 bpm. The occurrence of AV block in the atrial group was recorded. During follow-up (mean, 5.5+/-2.4 years), there was no change in PQ interval in either group and no change in atrial stimulus-Q intervals or Wenckebach block point in the atrial group. Four of 110 patients in the atrial group developed grade 2 to 3 AV block that required upgrading of the pacemaker (0.6% per year). Two of these 4 patients had right bundle-branch block at pacemaker implantation. CONCLUSIONS: AV conduction, estimated as PQ interval and atrial stimulus-Q interval at atrial pacing rates of 100 and 120 bpm and the Wenckebach block point, remains stable during long-term follow-up. Thus, treatment with single-chamber atrial pacing is safe and can be recommended to patients with sick sinus syndrome without bundle-branch block.

Aged↗

PubMed1998

[Hereditary long QT syndrome].

The Long QT Syndrome (LQTS) is a hereditary disease, characterized by a prolonged QT-interval on the electrocardiogram and a high risk of syncope and sudden death due to ventricular arrhythmias. LQTS must be suspected in apparently healthy children and young people with syncope after emotional or physical stress. Untreated symptomatic patients have a high mortality, which is markedly reduced by sympathetic block. The knowledge of the diagnostic criteria for the LQTS, a detailed history including a family history and an ECG-recording with measurement of the QT-interval in every patient with inexplicable syncope will advance the diagnosis of the LQTS and improve the survival of these patients after proper therapy. The current knowledge on the molecular genetics, epidemiology, mechanisms of arrhythmias and therapy are presented with special emphasis on the defects in the control of ionic transport over the cell membrane caused by mutations in ion channels.

Adolescent↗

PubMed1998

Heart failure and echocardiographic changes during long-term follow-up of patients with sick sinus syndrome randomized to single-chamber atrial or ventricular pacing.

BACKGROUND: In patients with sick sinus syndrome, choice of pacing mode has been implicated in the development of congestive heart failure. METHODS AND RESULTS: A total of 225 consecutive patients with sick sinus syndrome and intact atrioventricular conduction were randomized to either single-chamber atrial pacing (n = 110) or single-chamber ventricular pacing (n = 115). Clinical assessment included New York Heart Association classification, medication, and M-mode echocardiography before pacemaker implantation, after 3 months, and subsequently once every year. At long-term follow-up (mean, 5.5+/-2.4 years), NYHA class was higher in the ventricular group than in the atrial group (NYHA class I/II/III/IV: 65/44/4/0 versus 84/22/2/1 patients, P=.010). Increase in NYHA class during follow-up was observed in 35 of 113 patients in the ventricular group versus 10 of 109 in the atrial group (P<.0005). Increase in dose of diuretics from randomization to last follow-up was significantly higher in the ventricular group than in the atrial group (21+/-49 versus 8+/-42 mg furosemide/d, P=.033). The left ventricular fractional shortening decreased significantly in the ventricular group (from 0.36+/-0.12 to 0.31+/-0.08, P<.0005) but not in the atrial group (from 0.35+/-0.13 to 0.33+/-0.09, P=.087). The left atrial diameter increased significantly in both treatment groups (ventricular group: from 34+/-7 to 41+/-7 mm, P<.0005; atrial group: from 34+/-6 to 37+/-7 mm, P=.002), but the increase was significantly higher in the ventricular group than in the atrial group (P<.0005). CONCLUSIONS: During long-term follow-up, ventricular pacing is associated with a higher incidence of congestive heart failure and consumption of diuretics than atrial pacing. This is accompanied by a decrease in left ventricular fractional shortening and an increased dilatation of the left atrium in the ventricular paced patients.

Aged↗

PubMed1998

[Arrhythmogenic right ventricular cardiomyopathy].

Arrhythmogenic right ventricular dysplasia is a rare cardiomyopathy, but a frequent cause of ventricular tachyarrhythmia and sudden cardiac death among young otherwise healthy individuals. This article contains a review of the current knowledge on epidemiology, diagnosis, symptoms and signs as well as theories on etiology and pathogenesis, prognosis and treatment. The aim is to draw attention to the disease as a cause of syncope, ventricular tachycardia and sudden cardiac death.

Arrhythmogenic Right Ventricular Dysplasia↗

PubMed1998

Recovery of beat-to-beat variations of QRS.

There is a growing interest in the analysis of beat-to-beat variations of the morphology (BBM) of cardiac waves in electrocardiograms (ECG). Such analyses are confronted with the low BBM-to-noise ratio. An ECG clustering technique is introduced that brings the benefits of signal averaging to BBM analysis and recovers the beat-to-beat pattern of BBM. ECG clustering aligns waves and sorts them into clusters. The precision of the alignment was enhanced by sub-sample alignment. Kohonen's self-organising neural networks identified the clusters of the cardiac waves during training. The subsequent clustering of a wave results in a label for the closest cluster, a distance to the cluster and optimal alignment. Furthermore, ECG clustering avoids base-line variations and amplitude modulation sufficiently to be applied to the QRS wave in the raw ECG. The technique is demonstrated on 14 subjects with coronary heart disease and no myocardial infarction, myocardial infarction, or inducible ventricular tachycardia. ECG clustering is a general-purpose technique for beat-to-beat analysis, where the variations are cyclic as in the sinus rhythm. Results show that beat-to-beat variations in the QRS morphology are in general cyclic, with a main period of about four cardiac cycles. All calculations were performed with the Cardio software.

Coronary Disease↗

PubMed1998

A codon-based model designed to describe lentiviral evolution.

A codon-based model designed to describe lentiviral evolution is developed. The model incorporates unequal base compositions in the three codon positions and selection against the CpG dinucleotide within codons to account for a deficit of this dinucleotide exhibited by lentiviral genes. The model is, to a large extent, able to account for the pattern of codon usage exhibited by the HIV1 genes gag, pol, and env, in spite of its parameter paucity. The model is extended to a similar model which operates on pentets (codons and their neighboring bases). The results obtained by the pentet model establish the importance of depression of CpGs across codon boundaries as well as within codons. The goodness of fit of the CpG depression model to the observed evolution in pairwise alignments of HIV1 sequences is assessed. The model provides a significantly better description of the observed evolution than the simpler models examined. The parameter estimates indicate that part of the unusually large biases in nucleotide frequencies observed in HIV1 genes is caused by selection against CpGs. We find that the estimates of expected numbers of substitutions, of transitions to transversions, and of synonymous to nonsynonymous substitution rates are robust to CpG depression, whereas the ratio of CpG-generating substitutions to other substitutions is strongly influenced by the choice of model.

Base Composition↗

PubMed1998

Multisite pacing as a supplemental treatment of congestive heart failure: preliminary results of the Medtronic Inc. InSync Study.

This report describes the initial results of the "InSync" study, a European and Canadian multicenter trial that examines the safety and efficacy of a multisite pacemaker (Medtronic InSync) and of left ventricular pacing leads (Medtronic 2187 and 2188) implanted via a cardiac vein as a supplemental treatment of refractory congestive heart failure. Over a 10-month period, the system was implanted successfully in 68 of the 81 (84%) patients who had been enrolled in the study. The 68 patients were, on average, 66 +/- 10 years old, had a mean left ventricular ejection fraction (LVEF) = 21% +/- 9%, and 63% were in NYHA functional Class III and 37% were in Class IV. No system implant related complication occurred. During follow-up, 7 of 10 patients who exited the study had died, 4 suddenly. There was a clinical benefit among surviving patients, which was corroborated by a significant improvement in NYHA functional class and in the Minnesota Living with Heart Failure Quality of Life Questionnaire Score (MLS) and by a longer distance covered during a 6-minute walk test. This clinical improvement was associated with a significant narrowing of the paced QRS complex during biventricular pacing, a significant decrease in the interventricular mechanical delay, and a trend towards an increase in the duration of ventricular filling. These encouraging preliminary results confirm the feasibility and reliability of this new multisite pacing system in the management of dilated cardiomyopathy and support the continuation of further evaluations of this complementary treatment of refractory congestive heart failure.

Aged↗

PubMed1997

Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome.

BACKGROUND: In a previous study of 225 patients with sick-sinus syndrome randomised to either single-chamber atrial pacing (n=110) or single-chamber ventricular pacing (n=115), we found that after a mean follow-up of 3.3 years, atrial pacing was associated with significantly less atrial fibrillation and thromboembolism whereas there was no significant difference in mortality and heart failure between the two groups. We aimed to find out whether this beneficial effect of atrial pacing is maintained during extended follow-up of up to 8 years. METHODS: Follow-up visits for all patients were at 3 months, 12 months, then once a year at which patients had a physical examination, ECG recording, and pacemaker check-up. Endpoints were mortality, cardiovascular death, atrial fibrillation, thromboembolic events, heart failure, and atrioventricular block. Data was analysed on Dec 31, 1996. FINDINGS: At long-term follow-up, 39 patients from the atrial group had died versus 57 from the ventricular group (relative risk 0.66 [95% CI 0.44-0.99]; p=0.045). 19 patients from the atrial group and 39 patients from the ventricular group died from a cardiovascular cause (0.47 [0.27-0.82]; p=0.0065). The cumulative incidences of atrial fibrillation and chronic atrial fibrillation were also significantly lower in the atrial group than in the ventricular group (0.54 [0.33-0.89], p=0.012 and 0.35 [0.16-0.76], p=0.004, respectively). Thromboembolic events occurred in 13 patients in the atrial group and 26 in the ventricular group (0.47 [0.24-0.92], p=0.023). Heart failure was less severe in the atrial group than in the ventricular group (p<0.05). In multivariate analysis, atrial pacing was significantly associated with freedom from thromboembolic events (0.47 [0.24-0.92], p=0.028) and survival from cardiovascular death (0.52 [0.30-0.91], p=0.022), but no longer with overall survival (0.71 [0.46-1.08], p=0.11) or chronic atrial fibrillation (0.45 [0.20-1.05], p=0.063). Atrioventricular block occurred in four patients in the atrial group (0.6% annual risk). INTERPRETATION: The beneficial effect of atrial pacing found in our previous study is enhanced substantially over time. Patients with sick-sinus syndrome should be treated with an atrial rather than ventricular-pacing system because after long-term follow-up, atrial pacing is associated with a significantly higher survival, less atrial fibrillation, fewer thromboembolic complications, less heart failure, and a low-risk of atrioventricular block.

Aged↗

PubMed1997

Long-term follow-up of patients treated with implantable cardioverter defibrillators in a Danish centre. Accurrence ICD therpay and patient survivors.

The aim of the this prospective follow-up study was to evaluate long-term survival and implantable cardioverter-defibrillator (ICD) therapy for ventricular tachyarrhythmias in patients treated with an ICD in a Danish centre. A total of 140 consecutive patients (112 men), of which 70.7% had coronary artery disease, received an ICD at Skejby University Hospital between March 1989 and October 1996. Mean age was 55.6 +/- 14.6 years (range 14-78 years). After implantation, 136 of the patients were followed for a median (range) of 17.7 (0.4-74.1) months. Survival, mode of death and incidence of appropriate ICD therapy and therapy due to potential life-threatening ventricular tachyarrhythmia were the main outcome measures. Kaplan-Meier plots representing total survival, cardiac death, sudden cardiac death and first episode of ICD therapy are presented. After 1, 2, 3 and 4 years, respectively, the cumulative incidences of death were 9, 18, 20 and 24%, of cardiac death 4, 11, 14 and 18%, and of sudden cardiac death 2, 3, 6 and 6%. The cumulative incidences of appropriate therapy after 1, 2, 3 and 4 years were 47, 56, 66 and 80%, respectively. The cumulative incidences of cardiac death after the first episode of appropriate therapy were 9, 11, 15 and 20% after 1, 2, 3 and 4 years, respectively. The occurrence of ICD therapy and patient survival in the present study population treated with ICD at a Danish centre was comparable to results published previously from other larger centres. The rate of sudden cardiac death was low and most of our patients received appropriate ICD therapy during follow-up, indicating correct patient selection and probable benefit of the ICD device.

Adult↗

PubMed1996

[Treatment with implantable cardioverter-defibrillators. Experiences from Skejby hospital during the period 1989-1994].

The aim of the present study was to evaluate survival and therapy for ventricular tachyarrhythmia in patients treated with implantable cardioverter-defibrillator (ICD)-implantation at Skejby Hospital. Seventy-two patients, of which 54 were male, have received an ICD since 1989. Mean (range) age was 54 (16-74) years. Forty-nine (68%) had ischaemic heart disease. The patients were followed for a median (range) of 14 (1/2-50) months. Kaplan-Meyer plots are presented for total mortality, cardiac mortality, sudden cardiac mortality, appropriate therapy, and therapy for life-threatening tachyarrhythmia. After one, two and three years respectively, mortality was respectively 13, 27, and 32%, cardiac mortality was 5, 19, and 24%, sudden cardiac mortality was 3, 6, and 12%, cumulative incidence of appropriate therapy was 56, 66, and 90%, and cumulative incidence of therapy for life-threatening tachyarrhythmia was 19, 29 and 52%. It is concluded, that the majority of patients treated with an ICD developed ventricular tachyarrhythmia and had appropriate or lifesaving ICD-therapy during follow-up.

Adolescent↗

PubMed1996

Effect of residual noise level on reproducibility of the signal-averaged ECG.

Late potentials are detected at various noise levels in clinical studies. The aim of this study was to assess the effect of residual noise level on the reproducibility of the signal-averaged electrocardiogram (ECG). Two consecutive raw 15-minute ECG from each of 188 patients with coronary artery disease were digitized and stored on optical discs. Each raw ECG was analyzed by two signal-averaging procedures to noise level 0.2 microV or 0.4 microV. Standard time-domain parameters were measured: QRS duration (SA-QRS), late potential (LP) duration, and root-mean-square voltage of the terminal 40 ms of the filtered QRS (RMS40). The SA-QRS was prolonged by 12 +/- 14 ms by the reduction in noise level from 0.4 microV to 0.2 microV, LP duration was prolonged by 10 +/- 10 ms, and RMS40 was reduced by 19 +/- 22 microV. The temporal variation of the measured SA-QRS from ECG1 to ECG2 was significantly lower at noise level 0.2 microV (9 +/- 13 ms) than at noise level 0.4 microV (13 +/- 14 ms) (P < .001). The LP duration was also more stable at noise level 0.2 microV than at noise level 0.4 microV (0.5 +/- 11 ms vs 2 +/- 13 ms, P < .05). The presence of any two of three abnormal parameters (SA-QRS > 120 ms, RMS40 < 25 microV, LP duration > 40 ms) was used as the criterion for the presence of LPs. At noise level 0.4 microV, the proportion of patients with diagnosed LPs in ECG1 was 25% and at noise level 0.2 microV it was 62%. At noise level 0.4 microV, 20% were reclassified from LP-negative in ECG1 to LP-positive in ECG2, and 7% were reclassified from LP-positive in ECG1 to LP-negative in ECG2. At noise level 0.2 microV, 20% were reclassified from LP-negative in ECG1 to LP-positive in ECG2, and 9% were reclassified from LP-positive in ECG1 to LP-negative in ECG2. It was concluded that (1) the diagnosis of LPs is significantly dependent on the extent of noise reduction by signal averaging: and (2) the numerical reproducibility of signal-averaged QRS duration and LP duration is lower at noise level 0.4 microV then at noise level 0.2 microV; and the diagnostic reproducibility of LPs is similar at both noise levels.

Aged↗

PubMed1996

Noise in the signal-averaged electrocardiogram and accuracy for identification of patients with sustained monomorphic ventricular tachycardia after myocardial infarction.

Late potentials are detected at various noise levels in clinical studies. The aim of this study was, in a case-control design, to assess the effect of residual noise level on the identification of patients with sustained monomorphic ventricular tachycardia after myocardial infarction. Electrocardiograms from 16 patients with prior myocardial infarction and documented sustained monomorphic ventricular tachycardia and 41 patients with prior myocardial infarction and without ventricular tachycardia, were analysed by two signal averaging procedures to noise level 0.2 and 0.4 muV. Standard time domain parameters were measured. Two definitions of late potential were analysed: (1) if any two of the following criteria were present (signal-averaged QRS duration > 120 ms, late potential duration > 40 ms, and root-mean-square voltage of the terminal 40 ms of the filtered QRS < 25 muV); or (2) if the signal-averaged QRS duration > or = 120 ms. Overall the signal-averaged electrocardiogram performed better at noise level 0.4 muV compared to noise level 0.2 muV with respect to identification of patients with or without ventricular tachycardia after myocardial infarction. Reducing noise level from 0.4 to 0.2 muV increased the sensitivity, but the consequence was a substantial decrease in specificity. Our data indicate that when a high sensitivity is the goal, the definition based only on signal-averaged QRS duration > or = 120 ms should be applied; sensitivity was 88% and specificity 59% at noise level 0.4 muV. If a high specificity is the goal, the definition should be based on the definition with two abnormal parameters; sensitivity was 69% and specificity 68% at noise level 0.4 muV.

Adult↗

PubMed1996

Within- and between-patient variation of the signal-averaged P wave in coronary artery disease.

OBJECTIVES: To estimate interobserver, within-patient and between-patient variation of the signal-averaged P wave. To determine whether demographic, clinical, conventional ECG information, and coronary angiographic data are associated with the signal-averaged P wave duration in patients with documented coronary artery disease. BACKGROUND: A prolonged signal-averaged P wave may indicate the presence of a substrate for atrial tachyarrhythmias and may predict subsequent development of atrial fibrillation. However, information on variation, reproducibility, and determinants of the signal-averaged P wave are sparse. METHODS: One hundred ninety-three patients with angiographically documented coronary artery disease underwent two consecutive procedures of signal-averaging of P waves (SAECG1 and SAECG2). Interobserver, within-patient, and between-patient variation of the signal-averaged P wave was estimated (coefficient of variation: SD/mean). Multiple linear regression analysis was applied to identify parameters independently associated with signal-averaged P wave duration (SA-P). Atrial late potentials were considered if SA-P > 140 ms, and logistic regression analysis was applied to identify parameters associated with the presence of atrial late potentials. RESULTS: The interobserver, within-patient, and between-patient coefficients of variation for the signal-averaged P wave duration were 7.5%, 6.0% and 8.4%, respectively. The signal-averaged P wave duration correlated significantly with standard ECG P wave duration and height of the patient (r = 0.59). Forty-nine percent of the patients had atrial late potentials. P wave duration in the standard ECG correctly classified 73% (140/188) of the patients with respect to atrial late potential positivity or negativity. The sensitivity was 67% and the specificity was 78%. Agreement on the presence or absence of atrial late potentials between two observers was present in 71% (136/193) of the patients, and in 78% (151/193) between SAECG1 and SAECG2. CONCLUSIONS: The signal-averaged P wave has limited reproducibility in patients with coronary artery disease, and a normal or abnormal signal-averaged P wave can be predicted from the conventional ECG with high accuracy. It is recommended that the signal-averaged P wave be compared with the standard ECG P wave duration in follow-up studies with the aim of predicting atrial fibrillation.

Action Potentials↗

PubMed1995

Comparison among opsonic activity, antimeningococcal immunoglobulin G response, and serum bactericidal activity against meningococci in sera from vaccinees after immunization with a serogroup B outer membrane vesicle vaccine.

Opsonic activity in sera from 27 military recruits vaccinated with the Norwegian meningococcal serogroup B outer membrane vesicle vaccine was measured as respiratory burst with polymorphonuclear leukocytes as the effector cells and meningococci of the epidemic strain as the target. The results were compared with antimeningococcal IgG antibodies against an outer membrane vesicle coat in an enzyme-linked immunosorbent assay and with serum bactericidal activity. The vaccinees were immunized twice, with a 6-week interval between the two. The serum samples studied were collected at day zero, after 6 weeks, and after 12 weeks. Both serum bactericidal activity and respiratory burst were measured by adding external serum as the complement source. The results revealed a significant increase in specific IgG response, serum bactericidal activity, and respiratory burst after vaccination. We found a highly significant correlation between the responses in all three assays (P < 0.0001). The highest correlation was found between respiratory burst and antimeningococcal IgG response (r = 0.93). This result strongly indicates that respiratory burst is mediated almost exclusively by IgG antibodies. The correlation between antimeningococcal IgG response and serum bactericidal activity was slightly lower (r = 0.83). The correlation between respiratory burst and serum bactericidal activity was further reduced (r = 0.78), and some of the sera revealed a marked preference for only one of the activities. This result means that respiratory burst and serum bactericidal activity in part are induced by different mediators, and to obtain a more complete picture of the potential protective activity, both assays should be applied to survey a vaccine trial.

Adult↗

PubMed1995

The signal-averaged ECG becomes late potential-positive at low noise levels in healthy subjects.

Late potentials are detected at various noise levels in clinical studies. The aim of this study was to quantify the effect of residual noise level on the signal-averaged ECG. Thirty minutes of raw ECG (lead -X, +X, -Y, +Y, -Z, and +Z) from 10 healthy volunteers were digitized and stored on optical discs. Each ECG was analysed by four signal averaging procedures to noise level 0.1, 0.2, 0.3, and 0.4 microV, respectively. At each noise level, time domain analysis of the filtered vector (40-250 Hz) included determination of the QRS duration (QRS), late potential duration (LPD, duration of terminal signals below 40 microV), and root-mean-square voltage of the terminal 40 ms of the filtered QRS (RMS40). On average, the measured signal-averaged QRS duration was prolonged by 7.0 ms (range 0.9-12.5 ms) per 0.1 microV reduction in noise level. Late potential duration increased by 5.9 ms (range 0.2-10.0 ms) per 0.1 microV reduction in noise level, and RMS40 was reduced by 9.1 microV (range 0.5-20.2 microV) per 0.1 microV reduction in noise level. At noise level 0.4 microV, 0.3 microV, 0.2 microV, and 0.1 microV the number of late potential-positive subjects were 1, 2, 4, and 6, respectively. Late potential parameters are significantly dependent on noise level after signal averaging. Using conventional criteria for late potentials, healthy subjects become false-positive at low noise levels. Establishment of standards for noise level is recommended.

Adult↗

PubMed1994

[Late ventricular potentials after myocardial infarction].

Late potentials in the QRS complex can be detected with signal-averaged electrocardiography and are associated with delayed and disorganized ventricular activation. This article reviews the technique, describes the pathophysiological basis of late potentials, and assesses the prognostic value of late potentials for subsequent development of ventricular tachyarrhythmias and sudden cardiac death in postmyocardial infarction patients.

Age Factors↗