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Biomedical subjects

A K Pande

Publications and source records attributed to A K Pande.

At least 19 recordsLinked to original sources
PubMed2001

Chest trauma causing acute myocardial infarction.

We report a case in which blunt chest injury during football match caused an intimal tear in the left anterior descending coronary artery resulting into acute anterior wall myocardial infarction.

Adult↗
PubMed1998

The reaction of peroxynitrite with zeaxanthin.

The oxygenated carotenoids zeaxanthin and lutein, found in the macular area of the retina, may offer protection against or repair of oxidative damage associated with the degenerative diseases of aging. Since both superoxide and nitrogen monoxide, which react to form peroxynitrite, are found in the retina, we studied the reaction of peroxynitrite with zeaxanthin in liposomes. Zeaxanthin was easily incorporated into liposomes constructed from the fully saturated lipid L-alpha-dimyristoyl-phosphatidylcholine (C14:0) and from egg lecithin, and its absorbance spectrum in liposomes strongly resembles in shape and amplitude that of zeaxanthin dissolved in methanol. The reaction between peroxynitrite and zeaxanthin is first-order in both substrates. The pH profile indicates that the reaction with zeaxanthin involves peroxynitrous acid and not the conjugate anion. We hypothesize that zeaxanthin plays a major role in protection of macular tissue from oxidative damage.

Dimyristoylphosphatidylcholine↗
PubMed1996

Intravascular ultrasound for diagnosis of left main coronary artery stenosis.

Coronary angiography has many limitations for the assessment of coronary artery disease. Intracoronary ultrasound imaging may overcome some of these limitations by providing direct visualization of the luminal area. This report describes a case where intracoronary ultrasound imaging was useful for correct assessment of left main coronary artery disease which enabled avoidance of coronary artery bypass grafting in this patient. Intravascular ultrasound may be a good complement to coronary angiography in selected cases of left main coronary artery lesion.

Aged↗
PubMed1994

Coronary angioplasty for isolated non-dominant left circumflex coronary artery disease.

The study describes the clinical findings and results of coronary balloon angioplasty in 134 patients with non-dominant left circumflex coronary artery disease. The immediate angiographic success rate was 97% versus 95% for left anterior descending (P = NS), and 90% for right coronary lesions (P < 0.002). There was no hospital mortality in the circumflex group versus 1.2% in the left anterior descending (P < 0.01), and 0.4% in the right coronary artery group (P = NS). Major non-fatal cardiac complications were significantly lower in the non-dominant left circumflex coronary artery patients (no new Q-wave versus 3% in the left anterior descending, P < 0.0002, and 3% in the right coronary artery group, P < 0.01; no urgent coronary artery bypass grafting versus 2% in the left anterior descending, P < 0.001, and 1% in the right coronary artery group, P = NS). The freedom from chest pain was 63% in 112 patients (84%) with follow-up data available at 24 +/- 18 months, and mean angina class diminished to 0.7 +/- 1.3 (P < 0.001). Consumption of antianginal and other cardiac drugs was diminished during follow-up, and the number of patients on no such drugs increased from 5 to 32% (P < 0.001). Restenosis was found in 19 of 32 patients with repeat coronary angiography (59%). Repeat angioplasty was required in 22 patients during follow-up and in 4 of them (18%) it was done for new lesions. Angioplasty for isolated non-dominant left circumflex coronary artery disease yields excellent immediate and long-term results.

Angioplasty, Balloon, Coronary↗
PubMed1994

Percutaneous transluminal coronary angioplasty of left main coronary artery.

The present study is a retrospective analysis of 15 percutaneous angioplasty procedures of the left main coronary artery performed in 12 patients (8 males (66%) with a mean age of 64 +/- 12 (range 45-79) years. Twelve dilatations were elective: 8 for unstable angina, 3 for stable angina, and 1 after a recent myocardial infarction. All elective patients were protected with at least 1 patent graft to the distal left coronary artery. Emergency dilatation for evolving myocardial infarction with cardiogenic shock was done in 3 patients. The right coronary artery was dominant in 11 cases. The mean ejection fraction was 49 +/- 18% (range 21-7%). All dilatations were done through the femoral approach. Two dilatations were performed with the "kissing balloon" technique and 2 with the "kissing wire" technique. An intra-aortic balloon counterpulsation was used in 3 cases (21%). In 8 cases (53%), 1 additional coronary artery was dilated in the same session. The technical success rate was 100% and the clinical success rate 73%. For the elective dilatations, the technical success rate was 100% and the clinical success rate 92% (11/12). Four patients died during hospitalisation (27%). The mortality rate was 100% (3/3) for emergency dilatations and 8% (1/12) for elective dilatations (patient with dilatation of 3 vessels and 1 graft in the same session). After a mean follow-up of 25 +/- 28 (rang 1-88) months, the 8 patients discharged from hospital were alive.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1993

Implications of coronary angiography in patients with suspected or known coronary artery disease.

The study analyzes the incidence of coronary lesions and their implications on the treatment offered in 500 consecutive non-selected patients (406 males (81%), age 60 +/- 10 (+/- 1 standard deviation), range 21-88 years) undergoing coronary angiography for suspicion or confirmation of coronary artery disease (excluding patients with congenital and pure valve disease, or cardiomyopathy). A history of myocardial infarction was present in 205 patients (41%). There were no prior cardiac procedures in 334 patients (67%). There was prior coronary angioplasty in 82 patients (16%), coronary artery bypass grafting in 44 (9%) and both in 4 (1%). A total of 36 patients (7%) had had prior coronary angiography only. Mean left ventricular ejection fraction was 61 +/- 12 (18-83%) and mean left ventricular end diastolic pressure was 12 +/- 6 (2-37) mmHg. Angiographically normal coronary arteries were present in 61 patients (12%) and non-significant coronary lesions in 70 patients (14%). One vessel disease was present in 169 patients (34%), two vessel disease in 97 (19%), three vessel disease in 88 (18%) and left main coronary artery disease in 15 (3%). In single vessel disease, involvement of the left anterior descending coronary artery was seen in 82 patients (49%), left circumflex coronary artery in 38 (22%) and right coronary artery in 49 (29%). In two vessel disease, involvement of the left anterior descending coronary artery and left circumflex coronary artery was present in 30 patients (31%), left anterior descending coronary artery and right coronary artery in 36 (37%) and left circumflex coronary artery and right coronary artery in 31 (32%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

Success with coronary angioplasty as seen at demonstrations of procedure.

To assess the real-life results of coronary angioplasty, unidentified participants made notes on 104 cases demonstrated live at twelve international angioplasty courses in 1991. The initially planned procedure was successful in 73% with crossover to another device in 20% for an ultimate success rate of 93%. Interventions lasted an hour on average and two devices on average were used per artery tackled. Rates of success and of complication necessitating reintervention were, for balloon angioplasty (57 cases) 81% and 19%, for directional atherectomy (16 cases) 75% and 0%, for the Rotablator (12 cases) 42% and 42%, for stent implantation (10 cases) 100% and 0%, for excimer laser angioplasty (6 cases) 17% and 33%, and for Rotacs recanalisation (3 cases) 67% and 0%, respectively. The complications were occlusions (threatened, acute, or delayed) and they were usually treated by balloon angioplasty or a stent. No death or myocardial infarction was reported. The observer attending the demonstration tended to take a less favourable view of the outcome than the clinician doing the procedure and in general the results of coronary angioplasty seemed inferior to those reported in journals. Interventions done before an audience will be unusually stressful but this will be outweighed by the fact that difficult cases with a low probability of success are rarely tackled during live courses. This survey suggests that conventional balloon angioplasty, complemented by stent implantation in selected cases, is the treatment of choice.

Adult↗