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Biomedical subjects

A K Halperin

Publications and source records attributed to A K Halperin.

23 records · Page 2Linked to original sources
PubMed1984

Verapamil and propranolol in essential hypertension.

Twenty-four subjects with mild to moderate essential hypertension completed this 9-wk parallel, randomized, double-blind study of the antihypertensive effects of verapamil (V) (240 to 480 mg%) and propranolol (P) (120 to 360 mg%). V lowered systolic and diastolic blood pressures in all postural positions, with an average reduction of 20/16 mm Hg. With the exception of standing systolic blood pressure, P also lowered systolic and diastolic blood pressures in all postural positions, with an average reduction of 9/11 mm Hg. Differences between V and P were significant only for sitting systolic blood pressure. Heart rate was decreased by P but was not affected by V. The PR interval was prolonged by V. Plasma levels of V and P were directly related to dose. Plasma levels of V were linearly related to those of its major metabolite, norverapamil (r = 0.81). There was no correlation between clinical response and the dose or plasma level of V or P, but all subjects who received 480 mg% V had an average blood pressure reduction of 20/16 mm Hg and plasma levels of the parent drug above 200 ng/ml. V is an effective antihypertensive for mild to moderate essential hypertension. Constipation, pedal edema, and a maculopapular rash were reported as side effects of V.

Adult↗
PubMedDate not supplied

Ambulatory medical education: a reconsideration of sites and teachers.

This paper deals with the varied sites and teachers that can and should be used in educating residents and medical students in ambulatory care. A basic premise is that sites other than academic medical centers and teachers other than physician faculty members should be among those used. The paper describes how institutions have used non-traditional sites and teachers. Then, after emphasizing the need to choose settings according to curricular objectives, it discusses teaching sites, both hospital-based (general medical, specialty, and multidisciplinary clinics) and community-based (home care settings, rural clinics, nursing homes, and community clinics). Next it describes the array of current and potential teachers, which includes generalist and specialist physician faculty members, community physicians, residents, and allied personnel such as pharmacists and nurses. The paper also discusses forces resisting and supporting the use of new sites and teachers. It ends with general recommendations.

Ambulatory Care↗
PubMedDate not supplied

Evaluating cardiac risk in noncardiac surgery patients.

The cornerstones of the evaluation of cardiac risk in patients undergoing noncardiac surgery remain a thorough history and physical examination, and a resting electrocardiogram. However, new techniques to assess cardiac function allow more complete evaluation of high-risk patients.

Algorithms↗