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Biomedical subjects

A K Goyal

Publications and source records attributed to A K Goyal.

34 records · Page 2Linked to original sources
PubMed1989

Effects of a meal on normal and hypertensive portal venous system: a quantitative ultrasonographic assessment.

A prospective sonographic study was undertaken in age- and sex-matched normal subjects and patients with portal hypertension to evaluate the effects of a meal on the portal venous system. Postprandial increase in portal vessel diameters was proved to be statistically significant in normal individuals, with mean variations of 27.9% (16-60%), 46.5% (25-83%), and 45.2% (20-75%), respectively, for portal, splenic, and superior mesenteric veins. In contrast, this effect was insignificant in the hypertensive portal venous system. A diminished meal-related caliber variation in portal, splenic, and mesenteric veins less than 16%, 25%, and 20%, respectively, could be diagnostic of portal hypertension.

Adolescent↗
PubMed1989

Upper gastrointestinal haemorrhage in portal hypertension. Is an emergency endoscopy necessarily required?

Early fibre-optic oesophago-gastroduodenoscopy was performed in 23 portal hypertensive patients with acute upper gastrointestinal haemorrhage to evaluate the source of bleeding. Oesophageal varices grade II or more were documented in all patients. None of the patients showed a source of bleeding other than the ruptured oesophageal varices, probably because, unlike western countries, the alcoholic cirrhosis as a source of portal hypertension is rather uncommon in India. Hence, we could presume that most of the emergency endoscopies are unnecessary in bleeding patients with portal hypertension.

Adolescent↗
PubMed1989

Can sonography replace splenoportovenography in evaluation of patients with portal hypertension?

Real-time sonography and splenoportovenography were compared in 17 patients with portal hypertension for their relative efficacy and limitations with respect to diameters of portal vessels, visualization of collaterals and demonstration of portal vein occlusion. Sonography was able to diagnose portal vein thrombosis and to differentiate an occluded portal vessel from a patent portal vessel non-visualized due to hepatofugal blood flow in the presence of intrahepatic obstruction. However, sonography had limitations in demonstrating venous structures in the presence of excessive bowel gas or fat, and did not provide the flow patterns and the complete picture of the portal vasculature in a single setting. We conclude that the two procedures are complementary to each other, and if combined in patients with portal hypertension, the portal venous system can be evaluated more thoroughly for surgical treatment.

Adult↗
PubMedDate not supplied

Genetics of naphthalene and phenanthrene degradation by Comamonas testosteroni.

Naphthalene and phenanthrene have long been used as model compounds to investigate the ability of bacteria to degrade polycyclic aromatic hydrocarbons. The catabolic pathways have been determined, several of the enzymes have been purified to homogeneity, and genes have been cloned and sequenced. However, the majority of this work has been performed with fast growing Pseudomonas strains related to the archetypal naphthalene-degrading P. putida strains G7 and NCIB 9816-4. Recently Comamonas testosteroni strains able to degrade naphthalene and phenanthrene have been isolated and shown to possess genes for polycyclic aromatic hydrocarbon degradation that are different from the canonical genes found in Pseudomonas species. For instance, C. testosteroni GZ39 has genes for naphthalene and phenanthrene degradation which are not only different from those found in Pseudomonas species but are also arranged in a different configuration. C. testosteroni GZ42, on the other hand, has genes for naphthalene and phenanthrene degradation which are arranged almost the same as those found in Pseudomonas species but show significant divergence in their sequences.

Biodegradation, Environmental↗
PubMedDate not supplied

Differential diagnosis of ascitic fluid: evaluation and comparison of various biochemical criteria with a special reference to serum ascites albumin concentration gradient and its relation to portal pressure.

Among various biochemical indices measured in 93 patients with ascites, ascitic LDH estimation was proved to be indiscreminatory, while ascites/serum LDH ratio has shown a diagnostic accuracy of 85 per cent. Ascitic total protein levels and ascites/serum total protein ratio (accuracy rates of 72 and 77% respectively) were limited, especially in differentiating the ascites due to heart failure. Serum ascites albumin gradient, showed a strong correlation to portal pressure (r, + 0.83 + 0.88), and was found to be the best diagnostic index (with an overall accuracy of 97 per cent) in distinguishing the 'transudative' from 'exudative' ascites. However, no index could discreminate the 'mixed' cases and provide the etiological diagnosis of the ascites.

Adult↗