Biomedical subjects

A K Fried

Publications and source records attributed to A K Fried.

4 recordsLinked to original sources

PubMed2006

Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere.

Synthesis of a series of fused pyrazole tetrahydrofluorenone analogs which are potent, ERbeta subtype selective ligands is described. Analogs possessing subnanomolar ERbeta binding, greater than 100-fold ERbeta-selectivity, and oral bioavailability are reported.

Animals↗

PubMed2006

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.

Cell Line↗

PubMed1985

From skills lab to learning resource center: transformation through collaboration.

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Audiovisual Aids↗

PubMedDate not supplied

Computerized databases in nursing. Information at your fingertips.

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MEDLARS↗