Biomedical subjects
Publications and source records attributed to A K Badina.
The author revealed an increase of dienic conjugates in 391 patients under the effect of drugs in patients with drug intolerance and a study is also presented in 46 patients with good tolerance to drugs. It is shown that the dienic test has an information value as to intolerance of penicillin, streptomycin, tetraolean, analgin, novocaine and vitamin B1.
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A procedure for diagnosing drug allergy is described. It includes collection of the blood specimens, isolation of the lymphocytes, their incubation with an allergen and determination of the quantity of the diene conjugates in the lymphocytes before and after the incubation. When the quantity of the diene conjugates after the incubation with an allergen is 2 times as lower, the drug allergy is stated. The time course of the diene conjugate contents is followed up. A decrease in the initial level of the diene conjugates at least by 55 per cent in 7 patients with penicillin intolerance, in 4 patients with novocaine intolerance and in 1 patient with streptomycin intolerance could be indicative of the allergy atopic mechanism.