Anaesthesia and intraocular pressure.
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Anesthesia↗
Biomedical subjects
A K Adams
Publications and source records attributed to A K Adams.
In vivo placental permeability to hydrophilic solutes as a function of fetal weight in the guinea pig.
The permeability of the placenta was measured with unlabelled inulin in unanaesthetized guinea pigs. Inulin was injected into the sows and the plasma concentrations were recorded at regular intervals. The inulin contents of the conceptuses were calculated from fetal weights, fetal plasma inulin concentrations and a measured inulin distribution volume of 180 ml/kg fetus. From fetal inulin contents and the time integral of the difference in maternal and fetal plasma concentrations, we calculated a mean inulin permeability of 29 +/- 9 (s.e.m.) nl/s per gram placental weight. The inulin permeability per gram placental weight rose statistically significantly with increasing fetal weight. Comparison with a similar rise observed for the smaller cyanocobalamin molecule studied previously led to the conclusions that in the last ten days of gestation the transplacental passages narrow while at the same time there are apparent changes in the numbers and/or lengths of these passages that suffice to increase the unrestricted permeability fourfold.
Animals↗
The use of words.
The advantages of English as the language of communication for science and medicine by both the written and spoken word are discussed. A plea is made for clarity and brevity.
Communication↗
Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Euplotes.
In the ciliate Euplotes crassus a complex series of developmental events lead to formation of a new macronucleus. Millions of telomeres are synthesized during this process. We have shown that transcript levels are tightly regulated throughout Euplotes conjugation and macronuclear development. Thus, expression of gene products needed for macronuclear development and telomere synthesis appears to be controlled at the level of RNA abundance. To learn more about the role played by telomerase and the Euplotes telomere protein during telomere synthesis, we have correlated changes in the abundance of telomerase RNA and telomere protein mRNA transcript with specific developmental events. Telomerase RNA levels increase steadily during the early stages of macronuclear development and reach a peak just after telomere addition. The telomere protein transcript rises and falls twice during conjugation and then rises again at the time of telomere addition. The increases in transcript levels during conjugation parallel micronuclear division suggesting that the telomere protein is synthesized at this time and hence may have a micronuclear function.
Actins↗
Why do we need Royal Colleges?
Today's Royal Colleges can be traced to the guilds that arose during the 13th and 14th centuries. They fulfil similar roles: to maintain the highest standards of practice, professional integrity and self-regulation. This paper traces the development of the Royal Colleges, together with the emergence of specialisation within medicine, with particular reference to anaesthesia as a modern specialty. It considers whether these functions are still appropriate for the rapidly changing practice of medicine today. The colleges have unique strengths, but they also have weaknesses and must be prepared to counter threats to their professional function.
Anesthesiology↗
Human influenza: viral mutations and altered tropisms.
Influenza is a virus that is capable of causing a pandemic of the human race. Influenza has the ability to infect humans by mutating and altering its pathogenic characteristics. Efforts must be made worldwide to educate people about the possibilities of a potential outbreak. Awareness of optimal conditions which could lead to viral mutation and human to human transmission of a neogenetic strain of influenza appears to be a key deterrent against future cases.
Adolescent↗