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Biomedical subjects

A Jendryczko

Publications and source records attributed to A Jendryczko.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Activity of selected enzymes of the anti-oxidase system in the vitreous body, aqueous humor and lens after subconjunctival ozone in experiments].

The influence of ozone on the activity of enzymes of the antioxydation system in selected structures of the eye were checked. Ozone given topically in weak concentrations acts stimulating, increasing the activity of the enzymes of the antioxydation system, instead in high concentrations causes a significant reduction of activity of the enzymes of the mentioned system.

Animals↗
PubMed1992

Abnormal effect of sera from patients with atherosclerosis on calcium influx into normal erythrocytes.

The rheology of red blood cells in patients with atherosclerosis is abnormal. To investigate this further, the authors examined the effect of sera from patients with atherosclerosis on the handling of calcium by the erythrocyte membrane. Normal erythrocytes were filled with a photoprotein (aequorin) which emits light on contact with calcium. These photoprotein-loaded normal erythrocytes were then incubated overnight with the serum from normal subjects (n = 34) and from patients with atherosclerosis (n = 30). There was a significant decrease in basal calcium leakage, as measured by the amount of light produced following the addition of triton X-100. Induced calcium influx, as measured by the amount of light produced following the addition of ionophore A23817, was significantly greater in the photoprotein-loaded erythrocytes incubated overnight with the serum from patients with atherosclerosis compared with those incubated with the serum from normal subjects (p < 0.01). This modulation of Ca2+ handling in erythrocytes by a serum factor from patients with atherosclerosis could account for the alterations in erythrocyte function, such as red cell deformability, observed in atherosclerosis.

Adult↗
PubMed1992

Effect of low dose ionizing irradiation on rat metabolism.

Thie biological effect of low dose radiation is little known. In the current study male Wistar rats were exposed monthly to a 60Co-source low dose whole body irradiation (0.25 Gy, per 18 months; total dose: 4.5 Gy). The glutathione disulphide (GSSH): total glutathione (GSH) ratio, the concentration of thiobarbituric acid-reactive substances and the activities of glutathione peroxidase and glutathione transferase in: small intestine, spleen, kidney, soleus muscle, and liver were analysed. Low dose irradiation is accompanied by distinct peroxidative changes in organs, observed in the small intestine, the spleen and in the kidneys. The current study suggests that the measurement of glutathione status and thiobarbituric acid-reactive substances can be proposed as sensitive parameters for low dose radiation induced changes.

Animals↗
PubMed1992

Cholesterol palmitate in amniotic fluid: confirmation of a simple, rapid, inexpensive, and reliable indicator of fetal pulmonary maturity.

The cholesterol test was previously described and preliminary experience suggested it might be a rapid, inexpensive, and reliable indicator of fetal lung maturity. In this expanded series of 1342 patients delivered of infants within 72 hours of amniotic fluid analysis, the predictive value for mature test was 98.6%. Predictive value for immature test was 55.4%. For the phospholipid profile the predictive value was 97.0% for a mature test result, 31.2% for an immature result. These observations, coupled with its methodologic simplicity, make the cholesterol palmitate test a good first step in a cascade scheme of tests for fetal lung maturity and a valuable test in a facility where the phospholipid profile is not available 24 hours a day.

Amniocentesis↗
PubMed1991

The intracellular enzymatic response of neutrophils and lymphocytes in patients with precancerous states and cancer of the uterine cervix.

In patients with precancerous states and cancer of the uterine cervix prior to and after radiotherapy exhibit the decreased activity of neutrophil beta-glucuronidase. Moreover, patients treated by radiotherapy before the age 6 to 9 years demonstrate deficiency of N-acetyl-beta-glucuronidase in the above cells. The main finding in lymphocytes of the patients studied was in the appearance by diffusion of the above enzymes and of acid phosphatase in the cytoplasm, reflecting their release from lysosomes and immunological mobilization of these cells. The authors discuss the possible role of neutrophil enzymatic deficiency in lowering the antitumor cytotoxic effect of these cells.

Acetylglucosaminidase↗
PubMed1991

Serum 18:2 (9, 11) linoleic acid in normal pregnancy and pregnancy complicated by pre-eclampsia.

Serum 18:2 (9, 11) linoleic acid concentration was measured in normal pregnancy and pre-eclampsia. The 18:2 (9, 11) linoleic acid in normal pregnancy increased progressively with advancing gestation, reaching the highest value at the end of pregnancy. The 18:2 (9, 11) linoleic acid concentration in pregnancy complicated by pre-eclampsia was significantly higher than in normal pregnancy after week 28. It is suggested that measurement of the 18:2 (9, 11) linoleic acid concentration in plasma may be useful as a predictor of the likely development of pre-eclampsia.

Adult↗
PubMed1991

Regional variations in the activities of antioxidant enzymes in the term human placenta.

This study investigated the influence of the location of the sampling site during enzymatic analyses of 31 human term placentae. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase, glutathione reductase, and glucose-6-phosphate dehydrogenase were measured in fetal membranes, umbilical cords and placental disc. The disc samples were obtained from central (peri-insertion and mid-disc fetal and maternal halves), and peripheral regions. Significant variations were found. This study demonstrates the importance of defining the location of the sampling site in studies involving enzymatic analysis of the placenta.

Adult↗
PubMed1990

Increased placental phospholipase A2 activities in pre-eclampsia.

Phospholipase A2 activity was significantly increased in placental homogenates from 22 patients with pre-eclampsia in comparison to placental homogenates from women with uncomplicated pregnancy. Such an abnormality may be responsible for an altered release of free arachidonic acid, thus playing a major role in the pathogenesis of this syndrome.

Adolescent↗
PubMed1990

Myocardial lipid peroxidation in rats treated chronically with hydralazine and its amelioration by vitamin A.

The effect of long-term intake of hydralazine on myocardial lipid peroxidation (measured as formation of thiobarbituric acid-reactive substances and lipid peroxide concentrations), superoxide dismutase activity, and the protective action of vitamin A were studied in rats. Hydralazine was administered to rats for 6 months. Compared with the controls, the left ventricle of the hydralazine-treated animals had an increased thiobarbituric-acid reactive substance content and lipid hydroperoxide concentrations per g of wet tissue. Simultaneous administration of vitamin A prevented the changes in lipid peroxidation and significantly increased the superoxide dismutase activity compared with that in hydralazine-treated rats. The results seem to indicate that the increase of lipid peroxidation in rats treated with hydralazine is due not only to the stimulation, but also to the inhibition of superoxide dismutase activity.

Animals↗
PubMed1989

[Late sequelae of small doses of ionizing radiation in humans].

Toxic effects of low doses of ionizing radiation, below 100 rads, may appear within up to 20 years after irradiation. These effects include: increased incidence of leukaemias, pulmonary neoplasms, tumours of the thyroid, stomach and liver. The younger is the organism at the time of radiation exposure the shorter is the latency period of tumour development. Children irradiated in utero with low doses of X-rays exhibit delayed mental development. The period of particular fetal risk is 8-15 weeks of intrauterine life. In the first generation of irradiated males no chromosomal changes were revealed. The free-radical theory of tumour aetiology and the role of factors which may attenuate tumour development on the free-radical pathway are discussed.

Child↗
PubMed1989

[Free radical-related processes of mitochondrial aging].

Mitochondria are particularly susceptible cellular organelles to damage caused by free oxygen radicals. The authors explain certain processes taking place during ageing and leading to death in relation to mitochondrial ageing: an inverse correlation between the value of the basal metabolism rate and life span, the effect of antioxidant addition to the diet on body mass and length of life, the exponential type of the mortality curve as a function of age, the favourable effect of limited calorie content of the diet on life span and development of degenerative diseases.

Aging↗
PubMed1989

DNA damage in liver and kidney of rats after treatment with hydralazine in vivo.

Alkaline elution has been used to examine the integrity of DNA isolated from liver and kidney from rats treated with hydralazine (1-hydrazinophthalazine). Hydralazine was administered intragastrically at daily doses of 5, 10 and 25 mg per kg body weight to randomly bred female Wistar rats during 3 weeks. The relative strand scission, expressed as rad equivalents increased with increasing drug dose. The incidence of strand scission gives further support to the suggestion that hydralazine can be metabolically activated generating DNA-reactive species.

Animals↗
PubMed1989

[Vitamins A and E and vitamin A-binding proteins in the blood serum of patients with esophageal cancer].

The mean values of the vitamin A and the beta-carotene in the blood serum of patients with oesophageal cancer are lower than that in patients with nonmalignant oesophagus diseases and those with diseases other than malignancies and oesophageal diseases. The total protein and the albumin concentration in the blood sera did not differ when the above three groups of patients were compared. The concentration of vitamin E in the blood serum was similar in all three groups studied. The concentration of vitamin A in the group of patients with oesophageal cancer showed a marked correlation with the concentration of the vitamin A-binding proteins in the blood serum.

Adult↗
PubMed1989

Zinc, magnesium and copper in serum of women given a calcium supplement.

Earlier investigators have demonstrated in animal studies interrelationships between mineral elements. Serum zinc, magnesium and copper were monitored over a two year period in 120 women between the ages of 40 and 55 years. One group (65 women) was supplemented with calcium, the other served as a control. We concluded that calcium supplementation at a level of 1,500 mg Ca mainly does not affect serum zinc, magnesium and copper, however, serum copper concentration is elevated in women taking medication for hypertension.

Administration, Oral↗
PubMed1989

Placental phospholipase A2 activities in pre-eclampsia.

Phospholipase A2 activity was significantly increased in placental homogenates from 22 patients with preeclampsia in comparison to placental homogenates from women with uncomplicated pregnancy. Such an abnormality may be responsible for a altered release of free arachidonic acid, thus playing a major role in the pathogenesis of this syndrome.

Adolescent↗
PubMed1989

[Concentration of selenium and vitamin E in the serum of women with malignant genital neoplasms and their family members].

Lower concentrations of selenium and vitamin E were found in the serum of 50 women with malignant neoplasms of the genitals as compared with the concentrations in 55 healthy women family members of the patients living with them in common households. The degree of concentration decrease of these substances in the serum depended on the location of the tumour, and in cases of cervical neoplasms was 28% for selenium and 12% for vitamin E of the values in controls while in cases of ovarian neoplasms it was 34% and 37% respectively and in endometrial tumours it was 40% and 23% respectively. The third studied group comprised 36 healthy subjects not belonging to the families of the patients. The highest concentrations of selenium and vitamin E were found in the serum in the third group of women. The results suggest that various family factors not analysed in this study affect the concentrations of selenium and vitamin E in the serum of women with malignant neoplasms of genitals and in their family members.

Adult↗