Search PubMed⌕ Search

Biomedical subjects

A Janin

Publications and source records attributed to A Janin.

At least 163 records · Page 9Linked to original sources
PubMed1991

[Gaucher's disease and pregnancy].

Gaucher's disease is rare in association with pregnancy (we have only found 53 cases of women with this disease who had at least one pregnancy since 1945). A review of literature on this subject and this one case confirms that it is unlikely that the disease will progress as far as the symptomatology is concerned and that there are unlikely to be obstetric or fetal complications. All the same there are certain complications that can occur as the haematological state is concerned (thrombocytopenia, coagulation defects such as bleeding, particularly post-partum from the genital organs). Mechanical difficulties may occur because of the greatly enlarged spleen. Pregnancy is not contra-indicated but it is a high risk pregnancy that has to watched very carefully with ultrasound and great attention to the obstetric and biological condition.

Adult↗
PubMed1991

[Strictly epidermotropic "Ketron Goodman"-type lymphoma. Immunohistochemical and ultrastructural analysis of a case].

We report a case of T cell lymphoma which was exclusively located within the epidermis. The T cells of this lymphoma were all of suppressor-cytotoxic phenotype. They did not express the CD7 antigen and a molecular biology study showed T cell type genotypic rearrangements. Both immunohistochemical and ultrastructural studies showed close contacts between lymphoma and Langerhans cells.

Aged↗
PubMed1991

[Relapsing polychondritis and cartilage].

Atrophic polychondritis (APC) results from elective lesions of the components of elastic cartilage. Clinical criteria have been established in terms of the incidence of auricular, nasal, ocular, tracheobronchial or cochlear involvement. However, recent clinical and pathological reviews have shown the frequency and severity of vascular lesions, aortic as well as peripheral. Several pathological mechanisms probably participate together in the destruction of elastic cartilage. A direct enzyme abnormality of glycoaminoglycanes and of elastic tissue are believed to be interlinked with an auto-immune process bringing type II anticollagen antibodies into play.

Cartilage↗
PubMed1990

[Histologic aspects of the minor salivary glands in lupus erythematosus].

Minor salivary glands from 10 patients with LE, 5 patients with LE and keratoconjunctivitis sicca and 5 patients with primary Sjögren's syndrome were subjected to histological examination, immunoglobulin detection and lymphocyte typing. There was no clear-cut difference between the last two groups. The 10 LE patients had a moderate lymphocytic infiltrate (stage 1 or 2 according to Chisholm's classification with a predominance of T lymphocytes and a CD4/CD8 ratio greater than 1. Exsudative vasculitis with endothelial swelling and lymphocytes within the capillary walls was always present. These vasculitic lesions in LE distinguish it from the initial periductal involvement seen in primary Sjögren's syndrome.

Adult↗
PubMed1989

Antibiotic therapy of perforated appendicitis in children: a comparison of amoxycillin/clavulanate with a combination of benzylpenicillin, netilmicin and metronidazole.

This multicentre trial compared the clinical efficacy of amoxycillin/clavulanate used as a single-agent therapy with that of the three-agent combination usually prescribed in the post-operative period for appendicular peritonitis in children. Only bacteriologically documented peritoneal infections were included. Sixty-four patients were randomly distributed between two groups: Group A (29 cases) treated with amoxycillin/clavulanate, first administered iv (100 mg/kg/day) followed by conversion to the oral route (50 mg/kg/day) once the patient had been afebrile for 48 h; Group B (35 cases) first treated by the iv route with benzylpenicillin (100,000 IU/kg/day) plus netilmicin (5 mg/kg/day) plus metronidazole (30 mg/kg/day) followed by conversion to the oral route for metronidazole (30 mg/kg/day). In both groups, the total duration of parenteral and oral treatment was not less than five days. A total of 180 bacterial strains were recovered from peritoneal fluid samples obtained during surgery; 86% of these were sensitive to amoxycillin/clavulanate. Clinical efficacy, assessed on the basis of time until return to normal temperature and gut transit and duration of hospitalization, was identical in both groups, with follow-up monitoring on day 30 showing recovery in all cases. Cure was obtained without any problems of infection in 25/29 patients in group A and in 34/35 patients in group B (non-significant difference). Tolerance was excellent and identical in the two groups with the exception of three cases of thrombophlebitis which occurred in group B. The results of this study suggest that amoxycillin/clavulanate may be useful as single-agent therapy as a first-line curative treatment for appendicular peritonitis in children.

Amoxicillin↗
PubMed1989

Urinary tract infections with tissue penetration in children: cefotaxime compared with amoxycillin/clavulanate.

In children, the site of urinary tract infection (acute pyelonephritis or cystitis) cannot usually be accurately determined from the clinical presentation. The severity of the urinary tract infection (risk of renal scars) is best correlated with its estimated degree of tissue penetration clinically (fever, general condition) and on laboratory tests (sedimentation rate, C-reactive protein). The duration of parenteral antibiotic therapy, especially in children (taking account of difficult venous access and the cost of hospitalization) needs to be specified beyond the initial period required for sterilization of the urine (usually less than 48 h). We conducted a study in children older than one year to compare the efficacy and tolerance of two treatment regimens for urinary tract infection with tissue penetration: cefotaxime 100 mg/kg/d in four divided iv doses for 14 days (group I) and amoxycillin/clavulanate 100 mg/kg/d in four divided iv doses for seven days with conversion to the oral route at a dosage of 50 mg/kg/d for seven days (group II). The randomised protocol included ten patients in each group, comparable with respect to sex, age and history. Clinical efficacy (time until the patient became afebrile), bacteriological efficacy (sterilization of the urine), and biological efficacy (time to normalization of the indices of the acute inflammatory response) were identical for both groups regardless of the duration of iv antibiotic treatment (seven days for amoxycillin/clavulanate; 14 days for cefotaxime). The only side effect was diarrhoea, which affected three patients and did not require modification of the oral treatment regimen.(ABSTRACT TRUNCATED AT 250 WORDS)

Amoxicillin↗
PubMed1989

Placental metastasis from maternal bronchial oat cell carcinoma.

We describe the case of a young pregnant woman with oat cell carcinoma diagnosed by immunohistochemical reactions and ultrastructural study of a mediastinal biopsy specimen. A neonate was delivered by a cesarean section without evidence of carcinoma, but a thorough pathologic examination of the placenta showed intervillous metastasis of the maternal oat cell carcinoma. This case is interesting, since placental metastases from solid tumors are rare (38 reported cases with pathologic examination of the placenta), and 39% of them arise from maternal melanomas.

Adult↗
PubMed1989

[Alloimmunity and autoimmunity. I. Skin aspects].

Graft versus host reaction and autoimmunity. Acute cutaneous lesions and lupus erythematous. Clinical features Histological and ultrastructural features Immunopathological features Immunoglobulin deposits and circulating immune complexes Class II antigens Lymphocyte phenotypes Mechanisms leading to chronic lesions. Cutaneous aspects of chronic graft versus host-disease Early lichenoid eruption and idiopathic lichen planus. Clinical features Histological and ultrastructural features Lymphocyte phenotypes Late sclerotic phase and scleroderma Clinical features Histological and ultrastructural features Collagen immunotyping Pathological mechanisms.

Acute Disease↗
PubMed1989

[Morphologic diagnosis of pulmonary hemorrhage].

The gross and histologic morphologic features of early and advanced pulmonary hemorrhages are easy to recognize. Although there is no close correlation between the hemorrhagic appearance of the bronchoalveolar lavage fluid, the histologic features of hemorrhage, and the score of hemosiderin in alveolar macrophages, studies of bronchoalveolar lavage fluid samples are valuable for diagnosing and monitoring pulmonary hemorrhages.

Biopsy↗
PubMed1988

Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis.

A 4-month-old infant was admitted with a monoblastic infiltration of the skin associated with osteosclerosis. Both lesions spontaneously disappeared within a few months, but 2 years later, a monoblastic leukemia occurred that was associated with marked skin erythema and myelofibrosis. Skin and bone marrow specimens showed a monoblastic infiltration with numerous intermingled mast cells of normal appearance. Whether myelofibrosis was a feature of a systemic mastocytosis or of the leukemic process is discussed in this case.

Humans↗
PubMed1988

[Lipoblastic liposarcoma of the lung. Ultrastructural study of a case].

A case of fatal lipoblastic pulmonary liposarcoma in a 20 year-old female is reported. A thoracotomy was performed but failed to yield the pathological diagnosis. This diagnosis was obtained by ultrastructural study of a cerebral metastasis. To our knowledge, only seven cases of pulmonary liposarcoma have been previously described in the literature and the lipoblastic aspect was never mentioned.

Adult↗
PubMed1987

[Bronchial superinfection. Clinical trial of clavulanic acid-amoxicillin against josamycin].

Authors report a prospective clinical an bacteriological study in 32 patients, almost with a chronic bronchopulmonary disease. A group of 16 patients was treated with the association clavulanic acid-amoxicillin (ACA) and the 16 others with josamycin (J) for an acute exacerbation of bronchitis. Pus and numeration of bacteria in expectorations were the criteria of efficacity. Better results of ACA group were assessed with 14 cures (87%) against 4 (25%) (p less than 0.001) and no failure against 4 in J group (p less than 0.05). They conclude therapy with ACA is more effective and recommended in serious acute exacerbations in chronic bronchopulmonary diseases.

Aged↗