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Biomedical subjects

A Jain

Publications and source records attributed to A Jain.

At least 451 records · Page 25Linked to original sources
PubMed1979

Effect of naproxen on the kinetics of elimination and anticoagulant activity of a single dose or warfarin.

The purpose of this investigation was to determine the effect of the nonsteroidal anti-inflammatory drug naproxen on the elimination kinetics and anticoagulant activity of warfarin. Ten healthy men received one oral dose of 50 mg racemic warfarin alone and with naproxen, 375 mg twice daily for 17 days beginning 10 days before warfarin. Naproxen administration caused a small but statistically significant increase in the free fraction of warfarin in serum but had no significant effect on the total clearance, volume of distribution, half-life, and anticoagulant activity of warfarin. Warfarin, on the other hand, apparently enhances the serum protein binding of haproxen. There was substantial intersubject variation but very little intrasubject variation in the anticoagulant effect of warfarin. The intersubject variation of the anticoagulant effect was not related to the elimination kinetics of warfarin.

Adult↗
PubMed1979

Effect of naproxen on the steady-state serum concentration and anticoagulant activity of warfarin.

The purpose of this investigation was to determine whether the anti-inflammatory drug naproxen interacts with warfarin during prolonged administration of both drugs. Healthy adults received oral doses of warfarin daily for 26 days. Naproxen, 375 mg twice daily, was given from the eleventh through the twentieth days. Naproxen administration had no apparent effect on the steady-state concentrations of free and total (free and protein-bound) warfarin in serum, despite a small but statistically significant increase of the warfarin-free fraction in serum. There was no apparent difference between the prothrombin times (at a constant daily dose of warfarin) observed before, during, and after administration of naproxen.

Adult↗
PubMed1977

A multicenter analgesic study using single doses of placebo, propoxyphene and acetaminophen.

Six studies were conducted using identical protocols. The design involved single oral doses of placebo, propoxyphene, acetaminophen and a combination of the two drugs. Postpartum patients with either postepisiotomy or uterine cramp pain participated. Both efficacy and adverse reports were evaluated. The differences among medications were consistently less than one standard deviation from the mean for the studies indicating a lack of sensitivity to drug effects. In order of increasing effectiveness based on the pooled data, the medications were placebo, propoxyphene, acetaminophen, and the combination.

Acetaminophen↗
PubMed1976

Controlled evaluation of fenoprofen in geriatric patients with osteoarthritis.

A double-blind, crossover study compared the use of fenoprofen to aspirin in patients with osteoarthritis of large joints, most of them with knee involvement. A total of 24 patients participated in the study. Their ages ranged from 48 to 75 years, with an average age of 63 years. The mean daily dose was 1.8 gm of fenoprofen and 3.1 gm of aspirin in divided doses. Efficacy parameters showed that fenoprofen and aspirin provided significantly greater relief of osteoarthritis symptoms than placebo, and that the two active drugs were essentially equal in effectiveness. Fenoprofen was well tolerated in this group of patients. Only one patient discontinued the study during fenoprofen therapy because of side effects. The overall incidence of adverse reactions with fenoprofen compared favorably to that with placebo; the highest incidence was associated with aspirin therapy.

Aged↗