The second example of anti-Doa.
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Anemia↗
Biomedical subjects
A J Webb
Publications and source records attributed to A J Webb.
The halothane test: a practical method of eliminating porcine stress syndrome.
Pigs that are genetically liable to porcine stress syndrome can be detected around seven weeks old by their reaction to breathing halothane. Selection trials showed that the most probable form of inheritance for the halothane reaction was a single recessive gene. This halothane gene was also found to have good and bad effects on other economically important production traits, for example, improved carcase quality but reduced reproductive performance. The highest frequencies of the halothane gene were found in the pietrain and landrace breeds.
Animals↗
The disposition of 2-cyano-1-methyl 3-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)phenyl)guanidine in animals.
2-Cyano-1-methyl 3-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)phenyl)guan idine (SK&F 94836), a new positive inotrope/vasodilator, is being evaluated for the treatment of congestive heart failure. The absorption, metabolism, and disposition of the compound have been investigated in the rat, mouse, and dog. SK&F 94836 was rapidly absorbed, widely distributed, and rapidly and completely excreted primarily via the urine. There was no evidence of metabolism of the compound in any of the species studied. The compound showed minimal interaction with cytochrome P-450. The compound contains a chiral center. The enantiomers have been shown not to interconvert in either rat or dog. The serum protein binding was low in all species, including humans, and exhibited no stereoselectivity. Studies conducted in rat and dog using constant rate co-infusion of racemic SK&F 94836 and radiolabeled inulin have demonstrated that SK&F 94836 is eliminated by active tubular secretion.
Animals↗
Supracondylar fractures of the humerus in children.
Thirty-five children were evaluated at a mean of 2 years, 3 months following treatment of supracondylar fractures of the humerus. Elbow motion, clinical carrying angle, and roentgenographic measurements including Baumann's angle, humeral-ulnar angle, and metaphyseal-diaphyseal angle were determined for both the normal and the involved extremities. The humeral-ulnar angle best correlated with the final clinical carrying angle, followed by Baumann's angle and the metaphyseal-diaphyseal angle. We recommend postreduction measurement of the humeral-ulnar angle in fractures that have been surgically stabilized and Baumann's angle in those fractures treated by cast immobilization alone to determine the adequacy of reduction.
Child↗
Cytologic diagnosis of salivary gland lesions in adult and pediatric surgical patients.
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Adult↗
The lateral thyroid ligament of Berry.
Division of the lateral thyroid ligament is essential for total thyroid lobectomy. The exact extent of this ligament, first described by Berry in 1888, was studied in a series of 25 cadaveric and post-mortem subjects. The ligament was attached to the inferior margin of the cornu of the cricoid cartilage, near its pole, and extended infero-medially onto the tracheal wall, reaching the midline in 4 of the 50 lobes examined. At the level of the cricoid cartilage, the mean distance between the attachment of the ligament to the cricoid cartilage and the recurrent laryngeal nerve (RLN) entry point into the larynx was 1.9 mm. This region corresponds to the area where RLNs are mostly injured during thyroid surgery. Awareness of the extent of this ligament and the proximity of the RLN to it should lessen the risk of injury to the RLN during thyroid lobectomy and total thyroidectomy.
Cadaver↗