Biomedical subjects

A J Tapp

Publications and source records attributed to A J Tapp.

3 recordsLinked to original sources

PubMed1990

The treatment of detrusor instability in post-menopausal women with oxybutynin chloride: a double blind placebo controlled study.

Idiopathic detrusor instability is a common cause of incontinence in the elderly for which anticholinergic agents are regularly prescribed. Oxybutynin chloride combines anticholinergic action with direct muscle relaxant properties. We performed a double blind placebo controlled fixed dose cross over study of oxybutynin chloride in post-menopausal women suffering from detrusor instability. We found oxybutynin chloride significantly more effective than placebo at reducing the symptoms of urgency and urge incontinence and more effective at reducing the height of the highest unstable detrusor contraction. This was at the expense of an increased residual urine and considerable side effects.

Aged↗

PubMed1988

The prevalence of variation of resting urethral pressure in women and its association with lower urinary tract function.

Variation of resting urethral pressure has been reported and it has been postulated that this is important in the genesis of lower urinary tract symptomatology in women. In order to differentiate between normal and abnormal urethral pressure variations several arbitrary values have been chosen and the prevalence of abnormality in symptomatic women reported. However, large variations in urethral pressure may be seen in healthy, asymptomatic volunteers. We have identified the prevalence of urethral pressure variation in a large group of female volunteers and have shown that "abnormal" urethral pressure variation is not associated with lower urinary tract symptomatology.

Female↗

PubMed1986

The postmenopausal bladder.

Following the last menstrual period, a woman's "genital organs are sealed with the signet of sterility" (De L'Isère, 1850) and the ensuing hypo-oestrogenism, a consequence of ovarian failure, results in major metabolic disturbances. These include osteoporosis, thin skin, and an increased propensity for myocardial ischaemia. In association with these changes, lower urinary tract dysfunction occurs, also related to lower levels of circulating oestrogen.

Aged↗