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Biomedical subjects

A J Stunkard

Publications and source records attributed to A J Stunkard.

At least 37 records · Page 2Linked to original sources

Stigmatization of obesity in medieval times: Asia and Europe.

OBJECTIVE: To describe the stigmatization of obesity in medieval times in Asia and in Europe. DESIGN: Literature review. RESULTS: Obesity was stigmatized in medieval Japan in part, at least, because it was viewed as the karmic consequence of a moral failing in a Buddhist context. The stigma in Europe was based on the Christian deadly sin of gluttony. CONCLUSION: Stigmatization of obesity is not new. It was foreshadowed centuries ago by attitudes deriving from then extant theories of the origins of obesity.

Asia↗

Childhood sexual abuse and precursors of binge eating in an adolescent female population.

OBJECTIVE: We examined the cross-sectional association between childhood sexual abuse (CSA) and self-reported binge eating in an adolescent female population. METHODS: Study subjects were recruited from clinics specializing in the treatment of CSA, and control subjects were from high schools in the same cities. Height and weight were measured and subjects completed four questionnaires pertaining to binge eating, depression, locus of control, and self-esteem. RESULTS: Study subjects showed significantly higher depression, external locus of control, and binge eating, and significantly lower self-esteem and weight satisfaction scores than did control subjects. After adjusting for all covariables simultaneously, CSA was not an independent correlate of binge eating score. The strongest correlates of binge eating score in the multivariable analysis were depression, body mass index (BMI), and weight satisfaction. CONCLUSIONS: Psychological factors such as depression or weight satisfaction were more influential than is sexual abuse per se in the relationship between CSA and eating disorders.

Adolescent↗

The night eating syndrome in the general population and among postoperative obesity surgery patients.

OBJECTIVE: To determine the prevalence of night-eating syndrome in the general population and among a new sample of obesity surgery patients. METHODS: Night-eating syndrome was defined by presence of morning anorexia, excessive evening eating, evening tension and/or feeling upset, and insomnia. A randomly selected sample of 2,097 adults (survey sample) answered structured interview questions on night-eating syndrome. A self-report form was completed by 111 patients who had received gastric restriction surgery for obesity at a patient reunion (patient sample). RESULTS: Prevalence of night-eating syndrome in the survey sample was 1.5% (31 of 2,097). Prevalence in the patient sample was 27% (30 of 111). Weights for subjects in each sample, with and without the syndrome, were comparable. DISCUSSION: Prevalence of night-eating syndrome was higher in the patient sample than in the survey sample. Within each sample, presence of the syndrome was not related to weight. Prevalence in the survey sample was within the range reported for binge-eating disorder. Night-eating syndrome may warrant consideration as a distinct eating disorder.

Adolescent↗

Lifestyle modification in the pharmacologic treatment of obesity: a pilot investigation of a potential primary care approach.

This study examined a new method of providing brief, individual lifestyle modification to obese individuals treated by pharmacotherapy. Twenty-six women with a mean (+/- SD) age of 47.0 +/- 7.2 years, weight of 97.6 +/- 13.0 kg, and body mass index of 36.5 +/- 5.0 kg/m2 were prescribed 60 mg/d of fenfluramine and 15 mg/d of phentermine for one year. In addition, half of the women were randomly assigned to traditional group behavior modification, conducted by a nutritionist, which included 32 75-minute sessions during the year. The other half were provided lifestyle modification by a physician during 10 15-20 minute structured visits. All participants received identical treatment manuals and comparable assignments for behavior change. At the end of one year, patients in the physician group achieved the same highly successful weight losses as those treated by group behavior modification (13.9 +/- 9.6 kg vs. 15.4 +/- 7.9 kg, respectively). Treatment was associated with highly significant improvements in lipids and lipoproteins, as well as in mood and several measures of appetite. Weight loss the first four weeks, as well as patient completion of daily food records during the first 18 weeks, correlated positively with weight loss at weeks 18, 26, and 52. Results of this study await replication using larger samples but strongly suggest that effective lifestyle modification can be provided during brief, structured physician visits. The findings are discussed in terms of their implications for the treatment of obesity in primary care practice.

Adult↗

Effects of weight cycling on the resting energy expenditure and body composition of obese women.

OBJECTIVE: Numerous reports have suggested that cycles of weight loss and regain (i.e., weight cycling) are associated with adverse health consequences, a concern that may lead some obese individuals to forgo weight control efforts. The present study examined whether weight cycling was associated with a reduction in resting energy expenditure (REE) and with increases in both total and upper body fat. METHOD: REE, body composition, and body fat distribution were measured before and after weight loss, and following full weight regain, in 12 women who before treatment had a mean (+/- SEM) age of 38.8 +/- 3.4 years and weight of 98.0 +/- 3.2 kg. RESULTS: At the end of treatment, patients lost 18.9 +/- 2.6 kg which was comprised of significant decreases in body fat and fat-free mass of 15.2 +/- 2.2 and 3.7 +/- 0.8 kg, respectively (both ps < .001). REE also fell during this time from 1,631 +/- 82 to 1,501 +/- 51 kcal/d (p < .03). All of these measures, however, returned to their baseline values when patients regained their lost weight. Body fat distribution was unchanged throughout the study. DISCUSSION: These results do not support claims that weight cycling adversely affects REE, body composition, or body fat distribution.

Adipose Tissue↗

Current views on obesity.

Although the disorders associated with obesity have been extensively studied, little attention has been paid to the fact that obesity is itself a chronic disease. This misunderstanding of the nature of obesity has contributed to the stigmatization of obese persons and to the use of inappropriate or inadequate treatment regimens. Although the etiology of obesity is still unclear, genetic, metabolic, and social factors are all believed to play a role in its development and progression. Behavioral therapy, exercise, very-low-calorie diets, drug therapy, and surgery affect the treatment of obesity of differing levels of severity. The regaining of weight following treatments other than surgery is very frequent, in part because periods of weight loss are rarely followed by maintenance programs. An increasing awareness of the chronic, multifactorial nature of obesity will ideally lead to the development of new long-term treatment programs that are safe and effective. Such programs are urgently needed in light of new data that show that the prevalence of obesity is increasing in the United States, as much as 30% in the last decade.

Appetite Depressants↗

Psychological effects of weight loss and regain: a prospective evaluation.

This study prospectively assessed the psychological effects of weight loss and regain (i.e., weight cycling) in obese women. Measures of mood, binge eating, restraint, disinhibition, and hunger were obtained from 55 participants at baseline, after 6 months of treatment, and 58 months posttreatment. Women lost 21.1 +/- 8.4 kg after 6 months of treatment but were 3.6 +/- 10.9 kg above baseline weight at the time of the follow-up. Contrary to expectations, after this 21-kg cycle of weight loss and regain, women reported significant improvements in mood and binge eating, as well as reductions in hunger and disinhibition. Restraint was unchanged from baseline to follow-up. These data suggest that weight loss and regain are not associated with long-term adverse psychological effects. The findings also confirm earlier reports of significant weight regain after treatment and underscore the need for research to improve the maintenance of weight loss.

Feeding Behavior↗

Socioeconomic status and obesity.

Two recent developments have thrown into bold relief the importance of environmental forces in determining the prevalence of human obesity. The first is genetic studies that estimate the heritability of human obesity at no more than 33%. The second is the 33% increase in the prevalence of obesity in the USA during the past decade. The importance of the environment in influencing obesity is matched only by the extent of our ignorance of how it exerts its effects and of how we may favourably alter them. The most thoroughly studied measure of environmental influences is socioeconomic status. Among women in developed societies socioeconomic status is strongly (negatively) correlated with the prevalence of obesity: the lower the social class the more the obesity. Prospective studies have shown that this correlation reflects, in part, causation: socioeconomic status helps to determine the prevalence of obesity and thinness. Likewise, the presence of obesity helps to determine socioeconomic status. In developing societies there is also a strong relationship between socioeconomic status and obesity, but it is a positive one: the higher the socioeconomic status the more the obesity. Unfortunately, we know of few other social determinants of obesity and studies on the social determinants of this disorder are desperately needed.

Animals↗

Sertraline and relapse prevention training following treatment by very-low-calorie diet: a controlled clinical trial.

This study examined the combination of sertraline, a selective serotonin reuptake inhibitor, and relapse prevention training in the maintenance of weight loss following treatment by a very-low-calorie diet. A total of 53 women who had lost a mean (+/- SD) of 22.9 +/- 7.1 kg from a pretreatment weight of 103.1 +/- 17.8 kg were randomly assigned to a 54-week weight maintenance program that was combined with either: 1) 200 mg/d of sertraline; or 2) placebo. During the first 6 weeks, sertraline subjects lost significantly more weight and reported significantly greater reductions in hunger and preoccupation with food than did subjects on placebo. After this time, however, women in both conditions regained weight steadily. The 13 sertraline subjects who completed the 54-week study regained 17.7 +/- 10.6 kg of their original 26.3 +/- 7.6 kg loss, equal to a regain of 70.9 +/- 41.7%. The 17 placebo completers regained 11.8 +/- 9.0 kg of their 23.4 +/- 7.8 kg loss, equal to a 46.5 +/- 34.6% regain. End-of-treatment differences between groups in weight change were not statistically significant. Nor were there significant differences between the two conditions at any time in changes in fat-free mass, resting metabolic rate or dysphoria, all of which tended to increase with weight regain. The results are discussed in relation to findings from other long-term studies that combined diet and medication.

1-Naphthylamine↗

Influences of genes and shared family environment on adult body mass index assessed in an adoption study by a comprehensive path model.

The aim of this work was to explore the influences of the shared familial environment and the nonshared individual environment on body mass index in light of convincing evidence for genetic influence. A cross-sectional adoption design was used, including information on adult adoptees and their biological fathers and mothers, biological full siblings and paternal and maternal half siblings, and adoptive fathers and mothers. Body mass index (weight/height2) was derived from reported height and weight. A model of familial resemblance based on path analysis is used to test for effects of genetic influence and for effects of the environment shared among family members: transmission from the adoptive father and adoptive mother to the adoptee, from biological father and biological mother to biological children they reared, from the biological father to maternal half-siblings, from the biological mother to paternal half-siblings, and among biological siblings who may have lived together. The model also incorporates effects of assortative mating of the biological parents and of the adoptive parents, of shared preadoptive environmental influences between the biological mother and the adoptee, and of selective placement of the adoptee. The estimated heritability was 0.34 (standard error 0.03). No parameter indicating effects of shared familial environment either before or after adoption, assortative mating, or selective placement was significant. There was strong evidence for genetic effects, and no evidence for any effects related to the shared family environment--all familial resemblance in adults can be attributed to genetic influences. However, more than half of the interindividual differences in body mass index is due to nonshared individual environmental influences.

Adoption↗

Weighing the options: criteria for evaluating weight-management programs. The Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity.

The United States is experiencing an epidemic of obesity among both adults and children. Approximately 35 percent of women and 31 percent of men age 20 and older are considered obese, as are about one-quarter of children and adolescents. While government health goals for the year 2000 call for no more than 20 percent of adults and 15 percent of adolescents to be obese, the prevalence of this often disabling disease is increasing rather than decreasing. Obesity, of course, is not increasing because people are consciously trying to gain weight. In fact, tens of millions of people in this country are dieting at any one time; they and many others are struggling to manage their weight to improve their appearance, feel better, and be healthier. Many programs and services exist to help individuals achieve weight control. But the limited studies paint a grim picture: those who complete weight-loss programs lose approximately 10 percent of their body weight, only to regain two-thirds of it back within 1 year and almost all of it back within 5 years. These figures point to the fact that obesity is one of the most pervasive public health problems in this country, a complex, multifactorial disease of appetite regulation and energy metabolism involving genetics, physiology, biochemistry, and the neurosciences, as well as environmental, psychosocial, and cultural factors. Unfortunately, the lay public and health-care providers, as well as insurance companies, often view it simply as a problem of willful misconduct--eating too much and exercising too little. Obesity is a remarkable disease in terms of the effort required by an individual for its management and the extent of discrimination its victims suffer. While people often wish to lose weight for the sake of their appearance, public health concerns about obesity relate to this disease's link to numerous chronic diseases that can lead to premature illness and death. The scientific evidence summarized in Chapter 2 suggests strongly that obese individuals who lose even relatively small amounts of weight are likely to decrease their blood pressure (and thereby the risk of hypertension), reduce abnormally high levels of blood glucose (associated with diabetes), bring blood concentrations of cholesterol and triglycerides (associated with cardiovascular disease) down to more desirable levels, reduce sleep apnea, decrease their risk of osteoarthritis of the weight-bearing joints and depression, and increase self-esteem. In many cases, the obese person who loses weight finds that an accompanying comorbidity is improved, its progression is slowed, or the symptoms disappear. Healthy weights are generally associated with a body mass index (BMI; a measure of whether weight is appropriate for height, measured in kg/m2) of 19-25 in those 19-34 years of age and 21-27 in those 35 years of age and older. Beyond these ranges, health risks increase as BMI increases. Health risks also increase with excess abdominal/visceral fat (as estimated by a waist-hip ratio [WHR] > 1.0 for males and > 0.8 for females), high blood pressure (> 140/90), dyslipidemias (total cholesterol and triglyceride concentrations of > 200 and > 225 mg/dl, respectively), non-insulin-dependent diabetes mellitus, and a family history of premature death due to cardiovascular disease (e.g., parent, grandparent, sibling, uncle, or aunt dying before age 50). Weight loss usually improves the management of obesity-related comorbidities or decreases the risks of their development. The high prevalence of obesity in the United States together with its link to numerous chronic diseases leads to the conclusion that this disease is responsible for a substantial proportion of total health-care costs. We estimate that today's health-care costs of obesity exceed $70 billion per year.(ABSTRACT TRUNCATED AT 400 WORDS)

Body Weight↗

Decline in delayed-type hypersensitivity response in obese women following weight reduction.

The effect of weight loss on immuno function was evaluated in 14 middle-aged obese women. Cutaneous delayed-type hypersensitivity to five recall antigens was measured before a weight loss of 21 kg and again after weight had been stabilized. Weight loss was associated with a decrease in both number and magnitude of delayed-type hypersensitivity responses. The number of positive skin tests decreased from 3.1 +/- 0.2 to 2.4 +/- 0.3 per subject, and the mean cutaneous induration size decreased by 38%. The decrease in induration size was positively correlated with the decrease in body mass index (r = 0.63), weight (r = 0.59), and fat mass (r = 0.52). These preliminary findings suggest that large weight losses may result in decreased expression of immune function.

Adult↗

A 40-year history of overweight children in Stockholm: life-time overweight, morbidity, and mortality.

We describe the 40-year weight history and adult morbidity and mortality in a cohort of 504 overweight children, aged 2 months to 16 years, who were admitted for investigation of their overweight to four children's hospitals in Stockholm between 1921 and 1947. Follow-up information was gathered by questionnaire at 10-year intervals, most recently in 1980-1983 (n = 458), on weight history (based on the body mass index (BMI = kg/m2)), as well as prevalence of cardiovascular disease (n = 143), diabetes (n = 39), and cancer (all types (n = 20)), reported during the 40 years of follow-up, and mortality from all causes (n = 55), determined from death certificate. The sample of overweight children remained overweight as adults; after age 55 years, the BMI began to decline for both genders. Female subjects were heavier than their male counterparts from postpuberty onward. Subjects who died by the 40-year follow-up and those reporting cardiovascular disease were significantly (P < or = 0.05) heavier at puberty and in adulthood than were healthier subjects. There was a marked increase in the BMI between postpuberty and age 25 among those who subsequently died, those who developed cardiovascular disease, and particularly among those who developed diabetes (P < or = 0.001). In contrast, those reporting cancer had a lower BMI throughout adulthood than those who did not. We conclude that overweight in adolescence may continue into adulthood and may be associated with subsequent adverse health outcomes.

Adolescent↗

Binge-eating disorder in obese adolescent girls.

Thirty percent of 51 obese adolescent girls seeking treatment for their obesity engaged in binge eating. Two psychometric measures, "disinhibition" and "happiness and satisfaction" predicted 63% of the variance in severity of binge eating. There was no difference in the history of dieting between obese subjects who binged and those who did not.

Adolescent↗

Number of pregnancies and the subsequent risk of cardiovascular disease.

BACKGROUND: Whether increasing parity or gravidity is a risk factor for coronary heart disease has been debated, but the question remains unresolved. METHODS: We tested the association between the number of pregnancies and a variety of cardiovascular end points in two groups of women who had completed childbearing. One group comprised 2357 women who were followed for 28 years through the Framingham Heart Study, and the other 2533 women followed for at least 12 years through the first National Health and Nutrition Examination Survey National Epidemiologic Follow-up Study (NHEFS). RESULTS: The rates of coronary heart disease were higher among multigravid women than among women who had never been pregnant, in both the Framingham Heart Study and the NHEFS, but in both studies, the higher rates were statistically significant only in women with six or more pregnancies. For the women in the Framingham Study, the rate ratio adjusted for age and educational level in the group with six or more pregnancies (as compared with women who had never been pregnant) was 1.6 (95 percent confidence interval, 1.1 to 2.2). For the women in the NHEFS, the same adjusted rate ratio was 1.5 (95 percent confidence interval, 1.1 to 1.9). Adjustments for other known cardiovascular risk factors, including weight, did not markedly alter this risk. The rate of total cardiovascular disease was also significantly higher among multigravid women in the Framingham Study than in the women who had never been pregnant. CONCLUSIONS: In two prospective American studies, having six or more pregnancies was associated with a small but consistent increase in the risk of coronary heart disease and cardiovascular disease. Whether gravidity itself or some other unmeasured factor accounts for the increase in risk that we observed requires further investigation.

Aged↗

Breast-feeding reduces maternal lower-body fat.

The effect of breast-feeding on maternal anthropometric measures during the first 6 postpartum months was studied in 24 women. Mothers, who were seen in the hospital shortly after delivery and at monthly intervals thereafter, kept a record of their infant-feeding practices and provided three 24-hour dietary recalls per month. The women were placed in one of three groups according to their infant-feeding practices: breast-feeding exclusively, combination of breast- and formula-feeding, and formula-feeding only. Changes in anthropometric variables at 6 months postpartum were similar in the three groups, but mothers who breast-fed exclusively or partially had significantly larger reductions in hip circumference measurements (3.6% and 3.1%, respectively) and were less above their prepregnancy weights at 1 month postpartum (7.8% and 8.5% above prepregnancy weight, respectively) than mothers who fed formula exclusively (0.68% reduction in hip circumference and 13.7% above prepregnancy weight). Our findings indicate that a woman's choice of infant-feeding practice influences postpartum anthropometric changes, but these effects may be temporary.

Anthropometry↗

Does obesity run in families because of genes? An adoption study using silhouettes as a measure of obesity.

A number of studies, including the Danish adoption study, have shown that, in adults, the familial resemblance of obesity, as measured by the body mass index (weight in kg/(height in m)2), is mainly due to genes. The body mass index may reflect both fat and fat-free body mass. In this further analysis of the Danish adoption study, the degree of obesity was assessed by a silhouette score. There was a significant relationship in scores between the adult adoptees and their biological mothers and between the adoptees and their biological full siblings reared by the biological parents. Weaker, nonsignificant associations were found for the biological fathers and for the maternal and paternal half-siblings. There were no relationships in silhouette scoring between adoptees and adoptive parents. The results confirm the results of our previous analysis of body mass index. We conclude that human obesity is under genetic control, whereas the childhood family environment has little, if any, influence on obesity in adults. It is an important task for future research to identify the genes involved.

Adoption↗