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Biomedical subjects

A J Sill

Publications and source records attributed to A J Sill.

4 recordsLinked to original sources
PubMed1980

Prolactin and growth hormone responses in the amenorrhea-galactorrhea syndrome.

Fifteen patients with hyperprolactinemia, amenorrhea, and galactorrhea were studied; 10 of these patients had apparent tumors. Nine of 12 patients had a suppression of prolactin with oral L-dopa, and all of 4 patients undergoing dopamine infusion had suppression of prolactin. Eleven and 8 patients underwent chlorpromazine stimulation and insulin-induced hypoglycemia, respectively; none responded. Three of the 4 patients did not show a growth hormone response with dopamine infusion, and L-dopa testing failed to achieve a growth hormone response in 7 of 10 patients. The data suggest an intact dopaminergic inhibition of prolactin with exogenous agents. However, inhibition of endogenous dopamine by chlorpromazine failed to elicit a prolactin response. The disordered growth hormone response to dopaminergic agents suggests a central disorder of dopamine generation. The possible implication of these results with respect to the pathogenesis of hyperprolactinemia is discussed.

Amenorrhea↗
PubMed1976

Preliminary evidence for a human prolactin releasing factor.

Plasma from normal human subjects was subjected to a 3-phase methanol extraction. An increase in prolactin release from rat anterior pituitary tissue in vitro obtained with increasing doses of the plasma extract, while no increase in TSH release occurred. Control studies with an extract of simulated plasma using incubation medium with human serum albumin resulted in less release than a comparable plasma extract dose. The plasma extract did not lose activity with heating to 100 degrees C for 10 min, and incubation of normal plasma at 37 degrees C for 4 h prior to methanol extraction resulted in no loss of prolactin releasing activity. The plasma extract was subjected to cascade ultra-filtration through UM-10, UM-2, and UM-0.5 filters with no significant loss of prolactin releasing activity. Finally, the extract contained no TRH immunoreactivity. These results support the existence of a heat stable, ultra-filterable circulating PRF in human plasma. The origin of this material is unknown.

Adult↗