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Biomedical subjects

A J Rowan

Publications and source records attributed to A J Rowan.

66 records · Page 4Linked to original sources
PubMed1970

Persistent behavioural and electroencephalographic changes after single doses of nitrazepam and amylobarbitone sodium.

In a double-blind cross-over trial the effects of nitrazepam (5 and 10 mg.), amylobarbitone sodium (100 and 200 mg.), and placebo were compared in normal healthy young people. Though they reported a good night's sleep and adjudged themselves to be alert after all four drug treatments, behavioural tests showed their performance to be significantly impaired 13 hours after treatment with nitrazepam or amylobarbitone, and E.E.G. records showed more drowsiness and light sleep 18 hours after treatment with nitrazepam than with amylobarbitone or placebo. E.E.G. fast activity was more plentiful after drugs in either dosage than with placebo.

Adolescent↗
PubMed1970

Is reading epilepsy inherited?

A patient with primary reading epilepsy is reported. Her daughter has major and minor seizures and shows pattern- and photosensitivity. Both have discharges during reading. The implications of these findings are discussed.

Adult↗
PubMedDate not supplied

Unilateral truncal seizures: frontal origin.

The locus of origin of seizures involving the muscles of the trunk is unresolved. The brainstem has been postulated by some investigators, whereas others have implicated the parietal cortex. We report a patient with epilepsia partialis continua involving the rectus abdominus of one side in whom each contraction correlated with an epileptiform complex in the contralateral central-vertex scalp region. This appears to be the first instance in which ictal EEG has localized truncal seizures to an area that probably corresponds to the precentral cortex.

Abdominal Muscles↗
PubMedDate not supplied

Game-playing epilepsy.

A 25-year-old woman with documented generalized seizures evoked by playing checkers was given a battery of psychological tests as well as a series of cognitive and non-game-related tasks during a session of intensive EEG-video monitoring. Generalized epileptiform discharges during each task, as well as during intervals of checkers playing, were quantified to determine possible triggering factors. Previous reports have discussed the roles of attention, concentration, stress, thinking, and spatial processing in similar cases. Our analysis showed significant activation of the EEG only with tasks involving strategic thinking, i.e., considering a sequence of moves based on evaluating the consequences of previous moves.

Adult↗
PubMedDate not supplied

Comparative bioavailability of a generic phenytoin and Dilantin.

Generic substitution of antiepileptic drugs (AEDs) has been controversial, with many alleged instances of biologic and therapeutic inequivalence reported. The recall of a generic phenytoin (PHT) formulation used in the Veterans Administration (VA) medical system allowed us to evaluate the question of biologic equivalence systematically in a relatively large number of patients at the Bronx VA Medical Center. Serum PHT levels were 22-31% lower during the period of generic intake as compared with levels in the same patients receiving Dilantin. Review of the literature showed only one other adequately documented report of potential clinically significant inequivalence between a brand name and generic AED. Despite the apparent infrequency of generic inequivalence, several areas in which procedures for certification of therapeutic equivalence should be improved were identified.

Biological Availability↗