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Biomedical subjects

A J McCartney

Publications and source records attributed to A J McCartney.

14 recordsLinked to original sources
PubMed1990

Detection of pS2 messenger RNA in gynecological cancers.

Estrogen-inducible pS2 mRNA was previously detected in human cancer cell lines the growth of which was sensitive to estrogen. In the present study, the expression of the pS2 gene was analyzed in 111 gynecological carcinomas. The pS2 message was detected in greatest abundance in 6 primary carcinomas of the ovary (6 of 29), 4 of these being mucinous cystadenocarcinomas. A secondary carcinoma of the ovary, and another of the omentum (1 of 4), also contained detectable levels of pS2 mRNA. Weak pS2 mRNA signals were occasionally observed in endometrial (2 of 55) and cervical carcinomas (2 of 33) as well. There was a poor correlation between estrogen receptor and pS2 mRNA in ovarian carcinomas.

Biomarkers, Tumor↗
PubMed1990

Unusual gynaecological presentations of donovanosis as pseudo-elephantiasis and carcinoma of the cervix.

We report 2 unusual gynaecological manifestations of Donovanosis in young tribal aborigines. The first patient presented for medical attention after haemorrhaging from a large pedunculated lesion arising from the left labium minus and majus. This lesion was subsequently confirmed as pseudo-elephantiasis resulting from long-standing Donovanosis of the vulva. The second patient, with initial findings consistent with a diagnosis of advanced cervical malignancy, was referred to the oncology service of a tertiary referral centre. Because of her age and race a differential diagnosis of Donovanosis was considered and subsequently confirmed on special staining (Warthin-Starry) of biopsy specimens. No evidence of malignancy was found in these specimens.

Adult↗
PubMed1987

A chromosome study of three ovarian tumors.

The cytogenetic results of three different types of malignant ovarian tumors are reported. Their chromosomes were studied indirectly by using either peritoneal washings or ascitic fluids. Detected in the peritoneal washings from a treated case of serous cystadenocarcinoma with papillary involvement, stage III, was a clone of pseudodiploid cells. They were found after 12 months of chemotherapy. No supporting evidence of malignancy was found cytologically. Relatively simple karyotypes were obtained from metaphases found in the ascitic fluid of a patient surgically treated for an immature teratoma, stage II, grade 3. Consistent abnormalities found were trisomy 2, del(3)(p14), and der(5)t(5;8)(q33;q11). Of prime interest in a case of dysgerminoma, stage IV, was the finding of the isochromosome i(12p), a recognized nonrandom abnormality of malignant testicular tumors [1-5].

Adult↗
PubMed1987

Surgery of intraepithelial neoplasia, CIN, VAIN, and VIN.

The various surgical treatments of CIN, VAIN, and VIN have been discussed. The necessity for careful pretreatment, histological diagnosis and colposcopic mapping of the various conditions has been stressed. The relative risks of malignant progression of the various conditions have been discussed along with the various modes and methods of surgical therapy. The facts emerging are that traditional surgical therapy is giving ground to more modern techniques of ablation, particularly that of carbon dioxide laser photoevaporation therapy. Particularly in treatment of CIN and VIN, laser therapy has begun to show many advantages. Traditional surgical techniques for treatment of intraepithelial neoplasia of the lower genital tract in the female have, in response, become more conservative in their application with an emphasis on preservation and reconstruction. However, in some cases confirmation of early results by long-term follow-up will be necessary. The general tendency of close surveillance and conservative treatment befits the management of non-invasive genital tract intraepithelial neoplasia.

Biopsy↗
PubMed1986

Primary cytogenetic abnormality detected in an endometrial adenocarcinoma.

Cytogenetic findings obtained from an endometrial adenocarcinoma stage 1A are reported. The primary stem line was pseudodiploid with an abnormal chromosome #8. Three side lines were noted, which collectively involved chromosomes X, #8, #12, and two members of group D. A small percentage of cells was either pseudotetraploid or near-tetraploid. Double minutes were noted in one of the latter cells. Interest in the case is centered on the finding of what appeared to be the primary chromosomal change.

Adenocarcinoma↗
PubMed1986

The influence of estrogen and progesterone receptors on survival in patients with carcinoma of the uterine cervix.

The prognostic value of estrogen receptors (ER) and progesterone receptors (PR) was studied in 246 women with primary carcinoma of the uterine cervix. In addition to the receptor status information on tumor stage, histological type, age at operation, and menopausal status was recorded and analyzed. If the patient died the cause of death was ascertained. The median survival time for the 97 patients who died was 15 months and the survivors were followed for an average of 34 months. The survival curve was compared with an age, sex, and year of death matched West-Australian population. The survival curves for patients with ER+ or ER- and PR+ or PR- tumors were virtually indistinguishable. Overall survival in patients with cervical carcinoma is not influenced by the receptor status or the receptor concentration of the carcinoma.

Carcinoma↗
PubMed1985

Occult, high-risk endometrial cancer.

In a series of 173 consecutive patients with endometrial cancer treated by a fixed protocol 62 tumors (36%) appear "estrogen independent," i.e. there is no history of estrogen ingestion and no recognized risk factors such as obesity or diabetes mellitus. A high proportion of these tumors are of advanced stage and grade. Prognosis is poorer and mortality higher than for "estrogen-dependent" tumors. Twenty-two tumors were truly occult (no spontaneous vaginal bleeding). Factors which identify this high-risk group are described and the reasons for delay in diagnosis discussed. Spread by intraperitoneal dissemination is considered a major factor in the poorer prognosis. Cytology of peritoneal washings is a useful diagnostic and prognostic aid. An estrogen provocation test is suggested as a means of earlier recognition which could reduce mortality in this group.

Age Factors↗
PubMed1983

The effect of estrogen receptor status on survival in patients with endometrial cancer.

This study demonstrates a significantly increased survival time for women with estrogen receptor-positive adenocarcinoma of the endometrium when compared with that of those with estrogen receptor-negative tumors (p less than 0.05). This prognostic factor provides information which is additional to, and independent of, that provided by the histologic grade and myometrial penetration of the tumor.

Adenocarcinoma↗
PubMed1977

Duodenoscopy and endoscopic pancreatography in patients with postive morphine prostigmine tests.

Twenty-three patients with abdominal pain and positive morphine prostigmine tests underwent duodenoscopy and endoscopic retrograde cholangiopancreatography (ERCP). Sixteen demonstrated marked or moderate ampullary stenosis. The pancreatic duct was dilated in three and stenotic in four. Ampullary stenosis was confirmed in all patients who subsequently underwent sphincteroplasty. Only six patients had pancreatitis demonstrated by appropriate laboratory studies or at surgery. Relief of pain after sphincteroplasty was complete in ten patients during follow-up.

Adolescent↗