Biomedical subjects
Publications and source records attributed to A J Larner.
A patient with one-and-a-half syndrome due to brainstem ischaemia is presented. The case emphasises the importance of attempting to establish the aetiology of this syndrome--in this case infarction secondary to spontaneous vertebralartery dissection--when making therapeutic decisions.
Many articles have warned of the dangers of too much and/or too little potassium, calcium or sodium in the blood, but phosphate has not received similar attention. Yet, because of its pivotal role in intermediary metabolism and its close solubility product relationship with ionized calcium, disordered phosphate homeostasis can have profound clinical effects.
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This article briefly reviews some recent advances in the understanding of the immunological basis of peripheral neuropathies. Peripheral neuropathies associated with paraproteinaemia, though rare, have proven paradigmatic, some of the insights gained being applicable to the more common Guillain-Barré syndrome.
A patient whose slow-relaxing tendon reflexes returned to normal after cardiac pacing for complete heart block is reported. Since the patient was euthyroid, these observations add further weight to previous suggestions that intrinsic catecholaminergic mechanisms, as well as thyroid status, may play a role in the pathogenesis of slow-relaxing reflexes.
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