Biomedical subjects

A J Johnson

Publications and source records attributed to A J Johnson.

At least 127 records · Page 7Linked to original sources

PubMed1975

Intravenous infusion of salbutamol in the treatment of asthma.

The effects of i.v. infusion of increasing rates of salbutamol for up to 4 h were documented in ten convalescent asthmatic patients. 2 The major bronchodilator effect was seen at 4.16 mug/minute. A small further improvement occurred at infusion rates up to 25.0 mug/min but was not significantly better than that seen at the lower infusion rate. 3 Cardiovascular effects were minimal after 60 min at the lower rate and even at 25.0 mug/min mean heart rate rose by only 17.1 beats/minute. All patients tolerated the 4 h infusion well. 4 It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma.

Adult↗

PubMed1975

Experimentally induced infection of dogs, cats, and nonhuman primates with Ehrlichia equi, etiologic agent of equine ehrlichiosis.

Dogs (German Shepherd Dogs and Beagles), cates, rhesus macaques (Macaca mulatta), and baboons (Papio anubis) were inoculated with Whrlichia equi, the etiologic agent of equine ehrlichiosis. Within 3 to 7 days after inoculation, morulae were observed in the eosinophils of cats, neurtrophils of macaques and baboons, and in both neutrophils and eosinophils of dogs. The severe disease produced in horses by this agent was not a feature of E equi infection in dogs, cats, macaques, and baboons. However, a susceptible horse, inoculated with the pooled blood of 2 infected macaques, developed severe clinical signs of equine ehrlichiosis. Infection with E equi did not alter the susceptibiltiy of dogs to infection with Ehrlichia canis and did not prevent development of signs of disease resulting from this infection. The broad experimental host range from this infection. The broad experimental host range of E equi distinguishes it from other ehrlichial agents which are characterized by a rather narrow host range. The susceptibiltiy of nonhuman primates to infection with E equi provides a basis for consideration of the potential transmission of ehrlichial agents to man.

Animals↗

PubMed1975

A natural case of Schistosoma mansoni in the chimpanzee (Pan troglodytes versus).

A spontaneous infection with Schistosoma mansoni was found in a chimpanzee (Pan troglodytes versus) recently imported from Sierra Leone, Africa. Clinical signs consisted of anemia, liver enlargement, bronchial rales, and emaciation. The primary gross pathologic lesions included a fibrotic firm nodular liver and pulmonary edema and consolidation. Histopathologic examination revealed changes similar to the experimental syndrome of Manson's schistosomiasis in the chimpanzee. The diagnosis was confirmed by the presence of the eggs and larvae of Schistosoma mansoni.

Anemia↗

PubMed1975

Experimentally induced sarcocystis infection in calves: pathology.

Calves fed sporocysts of Sarcocystis isolated from the feces of dogs and coyotes became anorectic, lost weight, and became anemic and prostrate, and died. The most severe pathologic changes occurred between 26 and 33 days after infection; schizonts were found throughout the body. Schizonts were not found after this time. Sarcocytis cysts were in skeletal and cardiac muscles between 33 and 54 days. Necropsy revealed lymphadenopathy, paleness of the mucous membranes and visceral organs, ascites, hydrothorax, hydropericardium, and serous atrophy of fat. Ecchymotic or petechial hemorrhage was in heart, brain, serosa of the alimentary tract, and urinary bladder. Microscopic changes observed in nearly all calves consisted of hemorrhage, mononuclear cell (primarily lymphocytic) infiltration and edema in heart, brain, liver, lung, kidney, and striated muscle. Necrotizing myocarditis with dystrophic calcification of the striated muscle and fat, as well as nonsuppurative inflammation of meninges and glial nodules in the brain, was observed in several calves.

Adipose Tissue↗

PubMed1975

Effect of amprolium on acute sarcocystosis in experimentally infected calves.

Twelve calves were used to determine whether treatment with amprolium affected the severity of experimental Sarcocystis fusiformis infections. In each of 2 experiments, 2 calves received an oral dose of amprolium at 100 mg/kg of body weight for 30 days, 2 calves were similarly inoculated but received no medication, and 2 calves served as uninoculated, unmedicated controls. Data from overall weight gains, packed cell volume, body temperature, postmortem and histological examinations, and serum enzyme levels indicate that amprolium reduced the severity of experimental sarcocystosis.

Amprolium↗

PubMed1974