Search PubMed⌕ Search

Biomedical subjects

A J Jaap

Publications and source records attributed to A J Jaap.

22 records · Page 2Linked to original sources
PubMed1993

Increased microvascular fluid permeability in young type 1 (insulin-dependent) diabetic patients.

Microvascular fluid permeability was assessed by determination of the capillary filtration coefficient in the forearm of ten young Type 1 (insulin-dependent) diabetic patients with a short duration of diabetes, satisfactory glycaemic control and minimal evidence of microangiopathy, and ten age- and sex-matched control subjects. A strain gauge plethysmographic method with a computer based logging and analysis system was used. This enabled differentiation between the volume filling and fluid filtration components of the response to venous pressure elevation. The median capillary filtration coefficient was found to be significantly higher in the young diabetic patients in comparison with control subjects (9.2 x 10(-3) ml.min-1.100 g tissue-1.mmHg-1 vs 3.8 x 10(-3) ml.min-1.100 g tissue-1.mmHg-1, p < 0.001). There were no significant correlations between capillary filtration coefficient and either plasma glucose concentration, haemoglobin A1c or duration of diabetes. As there is no evidence from other studies to support an increase in capillary surface area in the forearms of young Type 1 diabetic patients, these results may reflect a primary change in microvascular fluid permeability.

Adolescent↗
PubMed1983

Relation of atrial fibrillation and high haematocrit to mortality in acute stroke.

Clinical and laboratory abnormalities and the presence of atrial fibrillation on admission were examined in relation to hospital mortality in a retrospective study of the 320 patients with acute stroke admitted to a medical unit in a 5-year period. Of clinical factors, only increasing age and the presence of coma were associated with mortality. Atrial fibrillation, present in 25% of all patients, was associated with an increased mortality in patients aged 60-79 years (67% vs 44%, p less than 0.01). In patients under 75 years the mortality associated with raised haematocrit (0.50 or more), present in 11% of all patients, was more than twice as high as it was in those with lower haematocrit (71% vs 31%, p less than 0.005). Other laboratory variables associated with a high mortality were increased levels of mean red cell volume, white cell count, erythrocyte sedimentation rate, globulin, and blood urea and creatinine; and decreased levels of albumin. The high prevalence of and increased mortality associated with atrial fibrillation and raised haematocrit in stroke patients indicate the need for further studies of stroke prevention and treatment in these patients.

Acute Disease↗
PubMedDate not supplied

Capillary filtration coefficient in type II (non-insulin-dependent) diabetes.

Changes in microvascular permeability may be important in the pathogenesis of diabetic microangiopathy. In order to assess microvascular fluid permeability, the capillary filtration coefficient was determined in the forearm of 24 normotensive type II diabetic patients with minimal evidence of microangiopathy and satisfactory glycemic control, and 24 age- and sex-matched control subjects, using a sensitive strain gauge plethysmographic system. The median capillary filtration coefficient was not significantly different in the type II diabetic patients and control subjects [5.3 (3.2 - 9.1) x 10(-3) mL.min-1.100 g tissue-1.mm Hg-1 versus 5.4 (3.5 - 8.0) x 10(-3) mL.min-1.100 g tissue-1.mm Hg-1, p = 0.98)]. There were no correlations between capillary filtration coefficient and age, blood pressure, body mass index, duration of diabetes, glycemic control, or the presence of microvascular complications. These findings contrast with type I diabetes, where capillary filtration coefficient is elevated at an early stage in the disease, and lend support to the theory that there are differences in early microvascular functional abnormalities between type I and type II diabetes.

Adult↗