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Biomedical subjects

A J Houtsmuller

Publications and source records attributed to A J Houtsmuller.

16 recordsLinked to original sources
PubMed1984

The influence of ticlopidine on the natural course of retinal vein occlusion.

A double-blind study was established to evaluate the platelet aggregation inhibiting effect of ticlopidine on the course of ocular vein occlusions. 35 patients with recent central retinal vein occlusions and 54 patients with retinal branch vein occlusions were treated for 6 months. Various ophthalmological and clinical-chemical parameters, including fluorescence angiography, were assessed. Compared with placebo therapy a significant improvement in visual acuity was observed with ticlopidine for branch vein occlusions; the same trend was seen for the central retinal vein occlusions. Increased ADP-induced platelet aggregation was frequently found: in 72% of the central retinal vein occlusions and 70% of the branch vein occlusions. For the Wu and Hoak test, these numbers were respectively 74% and 67%. Hypertension was seen in 55% of all occlusions, hyperlipaemia in 33%, and diabetes in 29%. The effect of ticlopidine was most pronounced in patients with increased platelet aggregation and least obvious in hyperlipaemia. Hypertension and diabetes did not apparently influence Ticlopidine's effects. It is concluded that the platelet aggregation inhibitor ticlopidine is effective in the treatment of recent ocular vein occlusions.

Adenosine Diphosphate↗
PubMed1980

Unsaturated fats and progression of diabetic retinopathy.

Two groups of adult-onset diabetics, matched according to 10 different criteria, were followed, biochemically and fluorescein-angiographically, over a period of 6 years. One group used a saturated-fat diet, and the other group of patients were on an unsaturated-fat diet, particularly rich in linoleic acid. Statistically significant differences were found in biochemical data and in the progression of diabetic microangiopathy between the two groups. The conclusion is warranted that a linoleic acid-rich diet, administered over an extended period of time, may inhibit the development of microangiopathy, or the deterioration of diabetic retinopathy.

Adult↗
PubMed1976

Fundus changes in primary hyperlipaemia.

The retinal vascular change described for two relatively young men and initially diagnosed as arteritis retinalis but subsequently regarded as an analogue of retinal lipaemia stresses the importance of biochemical exploration for a possible disturbance in the fat metabolism in unclear cases of retinal vasculopathy. If a disturbance in the fat metabolism is found, rational therapy will lead to disappearance of the vascular mural changes.

Adult↗
PubMed1968

Acanthocytosis.

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Abetalipoproteinemia↗