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Biomedical subjects

A J Dyson

Publications and source records attributed to A J Dyson.

11 recordsLinked to original sources
PubMed1981

How important is the sequence of administration of inhaled beclomethasone dipropionate and salbutamol in asthma.

Sixty patients with fairly stable asthma of mild or moderate severity entered a multicentre, double-blind cross-over trial, comparing the efficacy of inhaled beclomethasone dipropionate preceded 10 minutes earlier by inhalation of salbutamol with that of beclomethasone followed 10 minutes later by salbutamol during two consecutive three-month periods. Patients received beclomethasone 100 microgram and salbutamol 200 microgram four times daily. Analysis of occurrence of exacerbations, usage of additional inhaled salbutamol, peak expiratory flow rate and symptom scores showed no evidence that regular beclomethasone was more effective when preceded by salbutamol rather than when followed by it.

Adult↗
PubMed1981

Pulmonary strongyloidiasis and lung abscess.

We report a case of lung abscess associated with pulmonary strongyloidiasis which occurred in an asthmatic patient three years after migrating to Australia from Burma where strongyloidiasis is endemic. Thiabendazole was effective in eradicating the Strongyloides infection.

Humans↗
PubMed1980

Ketotifen in adult asthma.

The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.

Adolescent↗
PubMed1979

Lymph node tuberculosis: a comparison of treatments 18 months after completion of chemotherapy.

Ninety patients with lymph node tuberculosis were treated with either rifampicin and isoniazid or ethambutol and isoniazid for 18 months, supplemented by sheptomycin for the first two months. No differences emerged between the two regimens, either during treatment or during an 18 month post-chemotherapy follow-up. In 7% of patients lymph nodes enlarged transiently after the end of treatment and in 7% enlarged nodes persisted. No patient required further treatment. One patient was left with an intermittently discharging sinus in an operation scar.

Adolescent↗
PubMed1977

Indoramin--an alpha adrenoreceptor antagonist for airway obstruction.

Indoramin, an alpha adrenoreceptor antagonist, was given in tablet form, in addition to regular salbutamol by aerosol, to 30 patients with airway obstruction. Indoramin produced a small increase in peak flow rate, no change in forced expiratory volume in one second and no improvement in symptoms. Troublesome unwanted effects occurred in six patients.

Adult↗
PubMed1977

Lymph node tuberculosis: a comparison of various methods of treatment.

The treatment of lymph node tuberculosis has been studied in 108 patients. Chemotherapy consisted of 18 months' isoniazid with either rifampicin or ethambutol, plus an initial supplement of streptomycin. These 2 regimens were randomly allocated to 19 patients who had previously undergone excision of the lymph nodes, 56 patients who had undergone biopsy and 33 patients who had not had any surgical procedures. The majority of patients were of Indian or Pakistani origin (80%). Histological evidence of tuberculosis was obtained in 64% of the 108 patients and M. tuberculosis was cultured in 30%. No other mycobacteria were grown. Progress during treatment was uneventful in 65% of patients. Fresh nodes appeared during treatment in 12%, existing nodes enlarged in 13% and fluctuation developed in 11% of patients. Discharge and/or sinus formation was infrequent (7%), as was breakdown of a surgical scar (4%). Excision or aspiration after the start of chemotherapy was performed in 19% of patients. In the period up to the end of chemotherapy no difference emerged between the patients who received rifampicin with isoniazid and those who received ethambutol with isoniazid. Satisfactory results were obtained in 98% of the patients by the end of treatment although 13% still had slight node enlargement. The place of surgery is discussed. Follow-up will continue for 18 months after the end of chemotherapy.

Adolescent↗