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Biomedical subjects

A J Coulombre

Publications and source records attributed to A J Coulombre.

At least 19 recordsLinked to original sources
PubMed1983

Changes in retinoid binding levels during development of the chicken cornea.

[3H]-retinol binding to cellular retinol-binding protein (CRBP) increased more than five-fold in developing chicken corneal epithelium at 14 days of incubation, the time when the initial increase in corneal transparency occurs in the developing embryo. In contrast, [3H]-retinoic acid binding to cellular retinoic acid-binding protein (CRABP) was highest at the earliest stages and decreased progressively to a very low level in the corneal epithelium near the time of hatching. Thus, there appear to be changing and differing requirements for retinol and retinoic acid during development of the chicken cornea.

Animals↗
PubMed1979

Cataractogenesis: developmental inputs and constraints.

The developmental period during which the lens is susceptible to one or another cataractogenic influence, the types of cataracts that result, and the spatial and temporal patterns in which these cataracts become manifest are better understood in the context of the orderly sequence of steps by which the vertebrate lens develops. Thus, events attending lens induction, formation of the lens vesicle, deposition of the lens capsule, maturation of lens fibers, elaboration of lens sutures, and developmental changes in the relationship of the lens to the optic cup have implications for cataractogenesis. We have also seen that events in juxtalenticular tissues (eg, the zonule, the temporary hyaloid-lenticular vascular, the neural retina) can contribute to the development of lenticular opacities. Hereditary cataracts, as well as congenital cataracts produced in response to untoward environmental input, can be properly understood only within a dynamic developmental context.

Animals↗
PubMed1971

Morphogenesis of the collagenous stroma in the chick cornea.

The embryonic chick corneal epithelium produces a highly structured acellular matrix beneath its basal surface during early development. This matrix, which contains collagen, serves as a morphogenetic template for subsequent stromal development in that the three-dimensional architecture of the adult corneal stroma is initially established, in miniature, in this epithelially derived connective tissue. Examination of the early corneal epithelium and matrix in both the light and electron microscope suggests that self assembly of the matrix may be one of several important factors in the morphogenesis of this early connective tissue.

Animals↗