Biomedical subjects

A J Corrigan

Publications and source records attributed to A J Corrigan.

4 recordsLinked to original sources

PubMed1982

A BASIC microcomputer program for plotting the secondary structure of proteins.

An Applesoft BASIC program is presented which allows one to readily graph the secondary structure of a protein on the basis of information derived from its amino acid sequence. This applies the Chou/Fasman rules of predictions to the alpha-helix, beta-sheet and coil conformational parameters. The program produces a first approximation and provides the additional feature which permits specific modification in the plotted structure. These modifications produce a plot comparable to the existing data obtained from X-ray crystallography and manual computations.

Amino Acid Sequence↗

PubMed1979

Nature of the fructan of Streptococcus mutans OMZ 176.

The fructan of Streptococcus mutans OMZ 176 was shown to have a levan structure by comparing the chromatographic mobilities of the saccharides produced by partial acid hydrolysis of ghe fructan and known levan and inulin. This was confirmed by using concanavalin A as a lectin in a double-diffusion gel technique.

Chemical Phenomena↗

PubMed1977

The mechanism of dextransucrase action. Activation of dextransucrase from Streptococcus mutans OMZ 176 by dextran and modified dextran and the nonexistence of the primar requirement for the synthesis of dextran.

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Arthrobacter↗

PubMedDate not supplied

Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.

A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.

Antiviral Agents↗