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Biomedical subjects

A J Block

Publications and source records attributed to A J Block.

162 records · Page 9Linked to original sources
PubMedDate not supplied

Alcohol ingestion does not cause sleep-disordered breathing in premenopausal women.

Ingestion of 2 ml/kg of 100 proof vodka before bedtime did not cause sleep-disordered breathing or nocturnal oxygen desaturation in 20 premenopausal women. These findings are opposite to the results of earlier studies of men, in which ingestion of the same amount of alcohol significantly increased these findings. Protection of young women from sleep-disordered breathing or oxygen desaturation may be related to the respiratory stimulant effects of circulating progesterone.

Adult↗
PubMedDate not supplied

A study of the efficacy and safety of irbesartan in combination with conventional therapy, including ACE inhibitors, in heart failure. Irbesartan Heart Failure Group.

Because heart failure therapy with angiotensin-converting enzyme (ACE) inhibitors may not be optimal, owing to persistent levels of angiotensin II occurring through incomplete blockade and alternate pathways, the benefit of adding irbesartan, an angiotensin receptor antagonist, to conventional therapy, including ACE inhibitors, was examined. In this multicentre, randomised, double-blind, placebo-controlled study, 109 patients with heart failure (New York Heart Association functional class II and III) and left ventricular ejection fraction (LVEF) < or = 40% received stable doses of ACE inhibitors and diuretics before and throughout the study. Irbesartan was titrated as tolerated to 150 mg once daily in all patients. Exercise tolerance time (ETT), LVEF and clinical status were assessed at baseline and after 12 weeks. Compared with placebo, irbesartan in combination with conventional therapy, including ACE inhibitors, produced favourable trends in ETT and LVEF and was well tolerated in patients with mild to moderate heart failure.

Adult↗
PubMedDate not supplied

Continuous in vivo measurement of arterial oxygen saturation by oximetry.

A new device for continuous measurement of arterial oxygen saturation (SaO2), the Hewlett-Packard Model 47201A ear oximeter, was evaluated. The oximeter calculates saturation as a function of light transmittance through the patient's arterialized pinna. Oximeter SaO2 was compared with SaO2 calculated from 133 simultaneously obtained measurements of arterial blood pH and arterial oxygen tension in 19 subjects. The coefficient of correlation between these two is 0.9884 over a wide range of SaO2 (47 to 99 per cent) with a mean error of 1.09 per cent saturation. The line of regression with 95 per cent confidence bands is SaO2 (oximeter) = 6.51 + 0.93 (+/-0.02) SaO2 (arterial blood). The device permits continuous accurate measurement of SaO2 in vivo and is invaluable for indicating trends in clinical studies and appropriate times to do arterial blood studies.

Evaluation Studies as Topic↗