Biomedical subjects

A J Beld

Publications and source records attributed to A J Beld.

21 records · Page 2Linked to original sources

PubMed1975

Are muscarinic receptors in the central and peripheral nervous system different?

The concentration-dependent binding of atropine-3 H to membrane fractions from bovine tracheal muscle, parotid gland and caudate nucleus, measured by equilibrium dialysis, revealed the presence of virtually identical high affinity binding sites in all three tissues. Sch 1000 and Sch 1178 geometrical isomers of N-isopropylatropine bromide with a large potency ratio as antimuscarinics, inhibited atropine binding identically in all three tissues. Differences in properties of muscarinic receptors in these tissues are either non-existent or too small to be detected by the applied techniques.

Animals↗

PubMed1974

Stereospecific binding as a tool in attempts to localize and isolate muscarinic receptors. Part II. Binding of (plus)-benzetimide, (minus)-benzetimide and atropine to a fraction from bovine tracheal smooth muscle and to bovine caudate nucleus.

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Animals↗

PubMedDate not supplied

Muscarinic receptor sensitivity in airway smooth muscle of patients with obstructive airway disease.

The hypothesis of an increased muscarinic receptor sensitivity in airway musculature of patients with asthma, chronic obstructive bronchitis and emphysema was investigated through methacholine-induced contraction of isolated airway smooth muscle strips. Contractile responses were recorded isotonically in tracheal smooth muscle preparations of 5 patients with chronic obstructive bronchitis, 2 patients with emphysema and 1 patient with allergic asthma, as well as in bronchial tissue preparations of 7 patients with chronic obstructive bronchitis. The responses were compared to those obtained in airway tissue preparations of 25 control subjects. The sensitivity to methacholine was normal in all groups of patients. This suggests that muscarinic receptor behaviour is normal in airway smooth muscle of patients with obstructive airway disease.

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