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Biomedical subjects

A J Balaton

Publications and source records attributed to A J Balaton.

14 recordsLinked to original sources
PubMed1989

Neuroendocrine carcinoma (Merkel cell tumor?) presenting as a subcutaneous tumor. An ultrastructural and immunohistochemical study of three cases.

The clinical and pathological features of three unusual soft tissue tumors are presented. They occurred in the groin of elderly patients in the subcutaneous tissue. In Case 1, the inguino-crural tumor coexisted with a second mass in the pelvis. The tumors had a tendency to recur locally and to invade the regional lymph nodes. Metastatic dissemination of the disease resulted in the death of the patient in Case 3. Histologically, the tumors appeared composed of small round cells with scanty cytoplasms, arranged in diffuse, poorly cohesive or solid sheets. In places, a trabecular pattern was noted. Mitotic figures were numerous. Some cells exhibited argyrophil granules. The ultrastructural study revealed compact whorls of intermediate filaments and neurosecretory granules. All three cases displayed a paranuclear dot-like positive reaction with antibodies to cytokeratins and neurofilaments. A diffuse cytoplasmic immunostaining for neuron-specific enolase was present in Cases 1 and 2. Protein S-100, vimentin and leucocyte common antigen could not be demonstrated. All these characteristics, except for the subcutaneous location, are shared with neuroendocrine (Merkel cell) tumors of the skin.

Aged↗
PubMed1989

[Accelerated decalcification using microwaves].

The authors report a protocol for microwave-accelerated decalcification. In comparison to decalcification at ambient temperature, decalcification using the microwave oven is reduced by a factor of 9 for trephine biopsies and by a factor of 11 for bone samples.

Bone and Bones↗
PubMed1988

Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections.

An antiserum to carcinoembryonic antigen (CEA) and a monoclonal antibody to cytokeratin 19 (CK 19) were studied for their suitability as diagnostic reagents for the differential diagnosis of primary and secondary malignant epithelial tumours of the liver, on paraffin sections. With the antiserum to CEA, positive bile canalicular structures were found in 60 per cent of the hepatocellular carcinomas. All the cholangiocarcinomas and 66.6 per cent of the metastatic carcinomas were positive for CEA, without displaying a canalicular staining pattern. All the hepatocellular carcinomas were negative for CK 19. All the cholangiocellular carcinomas and the metastatic carcinomas were positive for CK 19. This staining profile may prove helpful in difficult diagnostic cases.

Adenocarcinoma↗
PubMed1988

Persistent perineal sinus following an abdominoperineal amputation: an unusual form of polyvinylpyrrolidone storage disease.

A 58-year-old man had a persistent perineal sinus following an abdominoperineal resection. An excision of the sinus was performed. Histology revealed that the sinus tract was bordered by a granulation tissue exhibiting numerous vacuolated cells containing polyvinylpyrrolidone. The origin of polyvinylpyrrolidone was related to lengthy irrigation of the fistula with Betadine.

Humans↗
PubMed1987

Paravertebral malignant rhabdoid tumor in an adult. A case report with immunocytochemical study.

A case of paravertebral malignant rhabdoid tumor in a 59-year-old man is described. The location of the tumor and age of the patient appear to be unique. The clinical evolution was aggressive and resulted in the death of the patient. The tumor exhibited the light microscopic features of a typical rhabdoid tumor. It was composed of poorly differentiated round or polygonal cells with acidophilic glassy inclusions and vesicular nuclei exhibiting prominent nucleoli. Immunohistochemistry revealed the coexpression of cytokeratin and vimentin in neoplastic cells.

Cell Nucleus↗
PubMed1987

[Vacuolated-cell microfollicular adenoma of the thyroid].

A case of vacuolated (signet-ring) cell microfollicular adenoma of the thyroid is presented and confronted to the pertinent literature. It is a rare lesion. Its histologic aspect, featuring vacuolated cells and microfollicules, sometimes clover-shaped, and the results of the mucin stains and thyroglobulin immunostaining confirm the follicular-cell nature of the tumor and exclude primary mucin-producing tumors of the thyroid. Arrest of folliculogenesis appears to be the basic mechanism of histogenesis in our case.

Adenoma↗