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Biomedical subjects

A Ito

Publications and source records attributed to A Ito.

At least 937 records · Page 52Linked to original sources
PubMed1982

[Adjuvant immunotherapy for carcinoma of uterine cervix with PSK].

The subjects in this study were 123 cases of patients with carcinoma of uterine cervix who underwent surgery and postoperative irradiation or only irradiation combining with PSK as adjuvant immunotherapy. The changes in the immunological status of the patients were studied using various types of immunological parameters, and the two-year survival rate was also followed up. DNCB and PHA skin reaction showed no particular differences between the control and the PSK combination group, but the blast-formation of lymphocyte by PHA tended to show a rapid recovery from the reduction of the postirradiation in the PSK combination group. From the observations of changes in the peripheral T gamma and T cells, the combination use of PSK tended to cause a decrease in T gamma and an increase in T mu cells, but the both cell numbers were fallen in the normal range. The two-year survival rate of stage III patients was somewhat higher in the PSK combination group than in the control group; however, the difference between both groups was not statistically significant.

Female↗
PubMed1982

Effect of phenobarbital on the development of tumors in mice treated neonatally with N-ethyl-N-nitrosourea.

This study was undertaken to evaluate the effect of phenobarbital on the development of neurogenic tumors induced in mice by neonatal administration of N-ethyl-N-nitrosourea (ENU). A total of 185 A/He mice was divided into four groups. Continuous oral administration of phenobarbital (0.05%) in drinking water was commenced 4 weeks after birth in group I. A single injection of 40 mg/kg of ENU was given subcutaneously on the back within 24 hr after birth in group II. After neonatal injection of ENU, phenobarital was commenced 4 weeks after birth in group III. Group IV was the untreated control. The experiment was terminated 12 months after birth. The serum level of phenobarbital at the end of the experiment was 8.7 microgram/ml in group I and 7.09 microgram/ml in group III. Neurogenic tumors were induced only in groups treated with ENU. The incidence was 5.7% in group II and 10.9% in group III, though the difference between the two groups was not statistically significant. A total of 3 tumors (3.0%) was induced in the central nervous system and 5 tumors (5.1%) in the peripheral nervous system. Histologically, the former were oligodendroglioma and the latter were schwannoma. Lung tumors, lymphomas and hepatic tumors were also induced by ENU, and in male mice phenobarbital had a suppressing effect on the development of liver tumors.

Animals↗
PubMed1982

Induction and characterization of gastro-duodenal lesions in mice given continuous oral administration of hydrogen peroxide.

The tumorigenicity of hydrogen peroxide (HP) was examined by administering 0.4% HP solution in drinking water to various strains of mice. In C57BL mice, gastric lesions in the forestomach occurred in over 67% of the mice treated with HP for 120 days and duodenal lesions were noted in over 80% of the mice that received HP for 60 days. Gastric lesions were found only in the glandular stomach and duodenal lesions were restricted to the peri-pyloric and proximal part of the duodenum. The lesions in both organs were often multiple. The gastric lesions were composed of erosion and hyperplasia and those in the duodenum were exclusively hyperplasia. In mice given 0.4% and 0.1% HP for 420 to 740 days, 5 and 1% of them, respectively, had duodenal cancer by histological criteria though they did not show any distant metastasis. In the control group, no cancer was noted in the same observation period. The incidence and average numbers of lesions in both the stomach and duodenum after 150 to 210 days of HP intake decreased or fell to zero if HP administration was interrupted for 10 to 30 days. In DBA and BALB mice given 0.4% HP for 90 to 210 days, the incidences of gastric lesions reached 30 and 10% at maximum, respectively, and the incidences of duodenal lesions were 60 to 100% and 40 to 69%, respectively.

Administration, Oral↗
PubMed1982

Strain differences of tumorigenic effect of neonatally administered N-ethyl-N-nitrosourea in rats.

The tumorigenicity of neonatally administered N-ethyl-N-nitrosourea (ENU) was studied in four different inbred strain rats, that is Wistar/Furth (WF), Long-Evans (LE), F1 of Wistar/Furth and Long-Evans (F1) and Fischer 344 (F344) rats. All strains developed tumors of the nervous system with high incidence (97-100%) during 6 months of observation. The incidence of tumor of the central nervous system, including the brain (82-88%) and the spinal cord (53-76%), was high in all strains, but that of the peripheral nervous system, including the cranial nerve (21-89%) and the spinal root (13-93%), differed by strain. The peripheral nervous system of WF and F344 rats had a low susceptibility to the tumorigenic effect of ENU, but that of LE rats had a high susceptibility. Many brain tumors were induced in the temporal and frontal cortex and subcortex in all strains of rats. Spinal cord tumors were observed at all levels of the white matter of the spinal cord without any predilection site. Spinal root tumors were located in lumbosacral plexuses in WF and F344 rats, but in LE and F1 rats cervical and thoracic root tumors were also observed. Histological examination revealed that most of the brain and spinal cord tumors were oligodendroglioma, but in F344 rats about half of the brain tumors were mixed glioma. Epidermoid cysts of the lumbar spinal cord were observed only in F344 rats. Tumors of the peripheral nervous system were so-called anaplastic schwannoma.

Animals↗
PubMed1982

[Clinical effects of netilmicin].

In the present study, we used netilmicin for the postoperative complications and obtained the following results. 1. Netilmicin was used in totally 29 cases; 23 with localized peritonitis, 4 with generalized peritonetis and 2 with wound infection. Excellent effects were obtained in 2 cases, effective results in 24 cases and ineffective results in 3 cases. The effective rate was 89.7%. 2. Adverse reactions or abnormal clinical laboratory test results which might be attributable to the use of netilmicin were not noticed.

Adult↗
PubMed1982

[Proximal ligation of the vertebral artery for treatment of vertebral aneurysms].

Vertebral aneurysms are not necessarily rare. In general neck clipping of vertebral aneurysms is the surest method for treatment of aneurysms, but as for vertebral aneurysms, it is often difficult to clip the neck without danger, because they cross over lower cranial nerves and are often fusiform. The indication of proximal ligation of the vertebral artery for treatment of vertebral aneurysms has not yet established. This procedure in 28 cases in the literature and our 3 cases treated successfully was discussed and following results were obtained. 1) Proximal ligation of the vertebral artery was useful for prevention of a rupture of vertebral aneurysms. 2) Intracranial ligation of the vertebral artery was better than the ligation in the cervical region. 3) It was necessary for the diameter of the contralateral vertebral artery to be, at least, approximately same. 4) In order the diameter of the vertebral artery to enlarge to 1.2 times as wide as that of a preoperative state, and the blood flow in the basilar artery to be enough, it was necessary for the contralateral vertebral artery not to be sclerotic.

Adult↗
PubMed1981

An alkaline metallo-proteinase in the human uterine cervix an changes in its activity by cervical ripening.

Human uterine cervix at term pregnancy was found to contain an alkaline metallo-proteinase by use of a synthetic substrate, 2,4-dinitrophenyl-L-Pro-L-Gln-Gly-L-Ile-L-Ala-Gly-L-Gln-D-Arg. The enzyme (with a molecular weight of 3.8 . 10(4)) was most active around pH 9.2 toward casein and N alpha-benzoyl-DL-Arg-rho-nitroanilide. [14C]-Gelatin and proteoglycan subunit were also substrates for the enzyme, but [14C]collagen was not. In particular, the enzyme digested gelatin 70-times faster than the novel neutral proteinase in the cervix. Although EDTA was a potent inhibitor, 1,10-phenanthroline, human serum, diisopropylfluorophosphate and elastatinal had no effect on the enzyme. Alkaline proteinase in term pregnant cervices was significantly higher than in non-pregnant ones.

Benzoylarginine Nitroanilide↗