[The role of the physician in prisoners' resocialization team].
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Criminology↗
Biomedical subjects
A Isaksson
Publications and source records attributed to A Isaksson.
Side localization of parathyroid adenomas by simplified intraoperative venous sampling for parathyroid hormone.
Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is safe, and the predictive value of a lateralizing gradient is high. It could therefore be used as an adjunct to surgical skill and noninvasive localization procedures in selected cases, for instance in patients with prior neck surgery and hypercalcemic crisis.
Adenoma↗
Clinical trials with a new iodinated lipid emulsion for computed tomography of the liver.
A new iodinated lipid emulsion, Intraiodol, for which animal studies have indicated better tolerance than for other iodinated lipid emulsions, was tested in 15 patients with malignant lesions, and in one patient with focal nodular hyperplasia. Repeated CT scans of the liver and spleen and blood tests were performed for 24 hours after intravenous injection of Intraiodol. The uptake of Intraiodol in the liver (peak mean 28.6 HU) was higher than in the spleen (peak mean 21.8 HU). The uptake of Intraiodol in malignant lesions was minimal (peak mean 2.8 HU). The detection rate of hepatic lesions was equal to or better than that achieved by US, CT, and/or CT angiography. However, liver uptake of Intraiodol was low in 2 patients with severe fatty infiltration. Intraiodol produced vascular enhancement up to one hour after injection since it was eliminated slowly from the circulation. The observed adverse reactions consisted of temporary metallic taste in 5 of the patients, fever and exacerbation of back pain in one patient, and transient thrombocytopenia in one patient. Alkaline phosphatase increased (17%, p less than 0.01) only at two hours, and erythrocyte count (6%, p less than 0.05) at 24 hours after injection. Our initial results indicate diagnostic advantages of Intraiodol without serious adverse reactions. Further clinical studies are required to confirm these findings.
Aged↗
[Serratia-mastitis in cows as a herd problem].
Clinical mastitis with infection of Serratia marcescens occurred in a tied-up dairy herd in Sweden on a scale widely exceeding what has hitherto been reported in veterinary literature. The herd contained 37 milking cows before the disease period but only 14 at slaughter 21 months later in spite of some recruitment. A very large number of mastitis cases, usually rather mild and of short duration, had then occurred--during one single month not less than 47 cases. Hardly any cow escaped the disease. Instead, the single cows fell ill at short intervals with mastitis in the same quarter as previously or in another quarter. Antibiotic therapy in clinical cases, dry cow therapy and teat dipping had no obvious effect. Serratia marcescens was isolated in all 14 slaughtered cows in one or more quarters. The morphological changes were remarkably mild. Isolated Serratia strains revealed no distinctive marks compared with ordinary saprophytic strains in laboratory tests. Serratia-contaminated sawdust used as litter was possibly the source of infection and the milking machine possibly the tool for the transmission of bacteria to the udder, in the latter case by the aspiration of contaminated sawdust when the claw was attached or detached, or it fell off during milking. The pathogenicity of the bacteria and the susceptibility of the cows to udder infection may have been increased.
Animals↗