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Biomedical subjects

A Ing

Publications and source records attributed to A Ing.

9 recordsLinked to original sources

Consumption of freshwater fish in Kahnawake: risks and benefits.

Kahnawake is a Mohawk community located on the south shore of the Saint Lawrence River near Montreal. A comprehensive study was conducted in 1996-1997 to address the local concern regarding health risks of contaminant exposure associated with freshwater fish consumption. Forty-two participants, including most of the identified active fishermen (n=33), were interviewed. Walleye, perch, bullhead, and smallmouth bass were the species most consumed. Average daily intake of locally caught fish was 23 g/day. Nutrient and contaminant levels of locally collected fish were analyzed. Fish were good sources of protein, polyunsaturated fatty acids (particularly omega-3 fatty acids), calcium, zinc, and iron. Levels of cadmium, lead, arsenic, polychlorinated biphenyls (PCBs), and other chlorinated pesticides were at least 10 times lower than the guideline levels. Mercury levels of some predatory fish exceeded the guideline of 0.5 microgram/g. Average daily intakes of all contaminants were below the guideline levels by a factor of 10 except for mercury. Average mercury intake rate was about one-third that of the guideline level (200 micrograms/week). Contrary to residents' perception, Kahnawake fish were not particularly contaminated. In view of the nutritional as well as cultural benefits, fishing and fish consumption may be promoted.

Adolescent↗

A database for environmental contaminants in traditional food in northern Canada.

The potential health effects of environmental contaminants in traditional food on indigenous peoples in Northern Canada have been a growing concern. We have conducted an extensive literature review on contaminant levels in Northern Canada through searches of commercial, private, and government databases for the years 1986-1995, including MEDLine, Agricola, Biological Abstracts, Current Contents, Applied Science and Technology, Biosis, CABCD, Aquatic Sciences and Fisheries Abstracts, CRIS/ICAR, and the Northern Aquatic Food Chain Contaminant Database. More than 20,000 data items were identified in over 50 published articles, unpublished data, government reports, and review articles. Ranges of levels of 13 contaminants in major traditional food groups collected from four geographical regions (Yukon, MacKenzie, Keewatin, Baffin and Northern Quebec) were calculated. Exposure levels, particularly according to different dietary patterns, were estimated and discussed in relation to guideline levels.

Animals↗

Chronic cough.

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Adolescent↗

Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit.

Extraocular muscles contain both fast-twitch and multiply-innervated, tonic-contracting fibres. In rat, these fibres collectively express numerous myosin heavy chain isoforms including fast-type embryonic and neonatal, adult slow twitch type I and fast twitch type II, and a fast isoform unique to extraocular muscle. Immunocytochemical and Western blotting results are presented which suggest that, in rabbit, an additional species, the alpha-cardiac myosin heavy chain, is present. The immunoreactive species is found in all rabbit extraocular muscles and in the extraocular muscles is expressed in almost all fibres which do not contain a fast myosin heavy chain. Positive identification of this isoform as the alpha-cardiac myosin heavy chain was obtained by sequencing a cloned PCR product derived from extraocular muscle mRNA unique to the 3'-end of rabbit alpha-cardiac myosin heavy chain mRNA. This is the first unequivocal demonstration of alpha-cardiac myosin heavy chain expression in extraocular muscle.

Amino Acid Sequence↗

Mucociliary function, ciliary ultrastructure, and ciliary orientation in Young's syndrome.

BACKGROUND: Mucociliary clearance is impaired in patients with Young's syndrome (obstructive azoospermia with recurrent sinobronchial disease), cystic fibrosis, and primary ciliary dyskinesia. No defect of cilia or mucus has been detected in Young's syndrome. METHODS: Ciliary function and ultrastructure, including ciliary orientation, were studied quantitatively in 20 patients with Young's syndrome and 20 normal subjects to determine the incidences of ciliary defects. Nasal ciliated epithelium was obtained from each subject and used for measurement of ciliary beat frequency and ultrastructural analyses. Ciliary orientation was determined by measuring ciliary deviation in electron micrographs; ciliary deviation is a measure of the relative orientation of cilia in relation to each other in which high values indicate ciliary disorientation. RESULTS: Ciliary beat frequency and the incidence of microtubular defects and numbers of dynein arms did not differ between patients with Young's syndrome and control subjects. In patients with Young's syndrome basal ciliary deviation (16.0 degrees) was similar to that in control subjects (14.1 degrees), but at the ciliary tip ciliary deviation (21.9 degrees) was greater than in healthy subjects (14.5 degrees). CONCLUSION: The relative disorientation of the distal ciliary axoneme in patients with Young's syndrome compared with normal subjects may be due to a structural defect but is more likely to be a consequence of abnormal mucus.

Adult↗

Liver blood flow after major hepatic resection.

The factors involved in liver regeneration are poorly understood, but it has been suggested that blood flow plays a role. This paper documents the changes in liver blood flow (LBF) that occur after major hepatic resection. Eight patients, ranging in age from 37 to 76 years, underwent liver resection. Liver blood flow was measured preoperatively and on days 1, 4 and 7 postoperatively by low-dose galactose clearance. There was a significant (p less than 0.01) fall in LBF on day 1 compared with the baseline value, followed by a significant (p less than 0.01) rise from the baseline value by day 4. By day 7, LBF had returned to baseline levels and was significantly (p less than 0.01) lower than on day 4. These changes in LBF may be related to the stimulus for liver regeneration and increased functional demands during the early regenerative phase.

Adult↗

Dysfunction of humoral immunity in anergic surgical patients: absence of anti-tetanus IgG antibody production.

The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to an in vitro system, where cells from four control subjects were shown to secrete anti-tet-IgG antibodies in response to polyclonal activators whereas cells from eight anergic patients did not. It is suggested that this failure of humoral immunity could account for the high risk of bacterial infections in anergy.

Adult↗