Biomedical subjects

A Indovina

Publications and source records attributed to A Indovina.

59 records · Page 4Linked to original sources

PubMedDate not supplied

Central catheter infection by Trichosporon beigelii after autologous blood stem cell transplantation. A case report and review of the literature.

A case of localized Trichosporon beigelii infection is reported in a 40-year-old woman with Ph+ chronic granulocyte leukemia who underwent autologous blood stem cell transplantation. On day +14 after autograft, while severely neutropenic, she developed a local infection involving the soft tissues surrounding the central venous catheter (CVC) point of entry into the subclavian vein. Trichosporon beigelii was isolated from culture of the CVC tip; resolution occurred after removal of the CVC, neutrophil recovery and antifungal treatment with amphotericin B and 5-fluorocytosine. To our knowledge this is the first case of CVC localized infection from Trichosporon beigelii after transplantation.

Adult↗

PubMedDate not supplied

High-dose therapy and autologous transplantation in amyloidosis-AL.

A 53-yr.-old woman with amyloidosis AL was treated with high-dose chemotherapy and autologous stem cell infusion in an attempt to suppress the amyloid secretion. A diagnosis of MGUS had been made six years earlier. During the last year her disease had progressively shifted to a full-blown picture of amyloidosis AL, with renal failure, proteinuria, renal amyloid deposition and plasma cell sheets in the marrow. After an unsuccessful attempt with standard-dose chemotherapy, she received a high-dose regimen of busulphan (14 mg/Kg) and melphalan (40 mg/m2), followed by the infusion of both autologous bone marrow and peripheral blood stem cells. She had full and prompt engraftment, but eight weeks post-graft developed interstitial pneumonitis: CMV was isolated. The patient died while in the intensive care unit. In the literature, this is the first case of amyloidosis AL treated with high-dose therapy and autologous transplantation.

Amyloidosis↗

PubMedDate not supplied

[Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects].

The author executed the renography with I-123-orthoiodohippurate in 18 normotensive patients and in 12 genuine hypertensive patients. The analysis of the renography allowed the computation of the mean kidney transit time of the I-123-orthoiodohippurate and the effective renal plasma flow. The two parameters were regarded cumulatively for both kidneys. The effective renal plasma flow was divided for the body mass index and in this way the flow for unit of the body mass index was computed. The results were tested with the t of Student and either the mean kidney transit time either the effective renal plasma flow were significantly decreased in the hypertensive patients. The author explains this observation saying that in the tested hypertensive subjects the turnover of the I-123-orthoiodohippurate is increased.

Adult↗

PubMedDate not supplied

Mobilization and collection of PBSC in healthy donors: a retrospective analysis of the Italian Bone Marrow Transplantation Group (GITMO).

BACKGROUND AND OBJECTIVE: The number of allogeneic transplants of peripheral blood stem cells (PBSC) is rapidly increasing. Collection of PBSC in healthy subjects currently implies the administration of G-CSF or GM-CSF and, of course, the use of apheretic devices. These procedures involve potential risks, in particular the risk of leukemia secondary to growth-factor treatment. To evaluate the current practice of PBSC mobilization and collection, and initially assess the short-term side effects and efficiency of procedures, the GITMO (Gruppo Italiano Trapianti di Midollo Osseo) promoted a retrospective cooperative study among the Italian centers. METHODS: Seventy-six healthy individuals donating to their HLA-identical or partially matched sibling recipients in seven Italian centers form the basis of the present analysis. The data were retrospectively collected by proper forms, pooled and analyzed by means of a commercially available statistical soft package. RESULTS: All donors received G-CSF as mobilizing agent with different schedules according to each single center policy. A median of 2.5 (range 1-4) aphereses per donor were run. The most frequent side effect was bone pain. In no case did the medium term follow-up reveal subjective complaints or laboratory modifications. After G-CSF mobilization, WBC and lymphocytes counts increased to a maximum of (mean +/- SD) 48.1 +/- 15.6 x 10(9)/L and 4.2 +/- 1.5 x 10(9)/L, respectively. The peak was reached on day 5 in both cases. Platelets decreased after the apheretic procedures, reaching a minimum of (mean +/- SD) 77 +/- 26 x 10(9)/L on day 8 and returning to normal values on day 11. Overall, the apheretic collection yielded (mean +/- SD) 18.6 +/- 19.2 x 10(8)/kg donor body weight MNC; 10.4 +/- 5.7 x 10(6)/kg CD34+ cells; 90.6 +/- 75.9 x 10(4)/kg CFU-GM and 4.3 +/- 1.8 x 10(8)/kg CD3+ cells. The target dose of 4 x 10(6)/kg CD34+ cells was harvested in 51.3% donors after a single apheresis, in 85.5% after the second, and in nearly 100% after a maximum of 3 aphereses. INTERPRETATION AND CONCLUSIONS: These data demonstrate that collection of adequate numbers of circulating progenitors is feasible and well tolerated in healthy donors. However, only careful monitoring of donors and international cooperation will help to definitively assess the long-term safety of G-CSF for mobilization of PBSC.

Adolescent↗

PubMedDate not supplied

[Relationship between left ventricular dysfunction studied by multigated radionuclide angiography and carotid stenosis examined by Doppler].

The multigated radio nuclide angiography was executed in 55 patients that were investigated for coronary heart disease and the left ventricular contour was determined in left anterior oblique view. The left ventricular contour was divided in 5 sectors and the isocontours (percentage of excursion between the systole and the diastole) and the regional ejection fractions were determined. The continuous wave Doppler test of the carotids was executed in the same patients. The patients were divided in 3 groups according to Doppler test: the group 1 owned the patients with the normal test (35 patients); the group 2 owned the patient with the moderately diseased test (14 patients); the group 3 owned the patients with frankly diseased test (6 patients). The following statistical analysis was executed: the 5 values of the isocontours and the 5 values of the ejection fractions were used to classify the patients in the 3 groups by mean of a discriminant analysis according to Fisher and the group for the highest conditional probability was considered for every patient. The analysis fixed that the 5 + 5 values of each patient classified correctly the 67.27 of the cases. If the only the values of the isocontours or of the ejection fractions or of the septum or of the ventricular lateral wall were used, the cases correctly classified were fewer. This paper contributes to the study of the relationship between the heart disease and the brain vessel disease and allows to regard the atherosclerosis a unique disease.

Carotid Stenosis↗