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Biomedical subjects

A Imagawa

Publications and source records attributed to A Imagawa.

At least 73 records · Page 4Linked to original sources
PubMed1987

Testing of brain-stem function in 134 patients complaining of impotence.

To determine the cause of brain-stem dysfunction for impotence, we studied the brain-stem function in 134 patients complaining of impotence and compared the results with their clinical records, erectile function tests, a papaverine test, dynamic cavernography and measurement of the penile brachial index. We found brain-stem dysfunction in 43% of the patients with impotence. Brain-stem dysfunctions tended to show characteristic differences in underlying disease and erectile dysfunction. We discuss the testing and direct treatment of the brain-stem dysfunction, and postulate it to be one cause of the impotence.

Adult↗
PubMed1987

[Clinical study on adenocarcinoma of the prostate].

In 92 patients with prostatic carcinoma who were treated at the Takamatsu Red Cross Hospital from January 1976 to December 1985, we analyzed the age, chief complaint, degree of advancement, grade of tumor, way of therapy and prognosis. The age of the patients was between 51 and 87 years (mean: 74.8 years). The most frequent chief complaint was dysuria. In terms of the degree of advancement, 14 cases were assessed as Stage A, 23 cases as Stage B, 16 as Stage C and 39 as Stage D. Analysis of the grade of tumor disclosed that 38 cases (41.3%) had well differentiated adenocarcinoma, 20 cases (21.7%) had moderately differentiated adenocarcinoma and 29 cases (31.5%) poorly differentiated adenocarcinoma. Forty-four of the subjects have already died. The 5-year survival rate was 41.2% when calculated pursuant to life table method. The 5-year survival rate was 85.7% for Stage A, 36.1% for Stage B, 53.4% for Stage C and 24.3% for Stage D. The 5-year survival rate was 54.7% for well differentiated adenocarcinoma, 61.7% for moderately differentiated adenocarcinoma and 12.7% for poorly differentiated adenocarcinoma. Comparison of the 3-year survival rate among the 4 ways of therapy revealed only a small intergroup difference; namely, the rate was 58.5% for hormone therapy, 51.6% for intraarterial neocarzinostatin therapy, 77.1% for total prostatectomy and 57.1% for radiation therapy. These results indicate that our way of chemotherapy, which chiefly employs intraarterial administration of neocarzinostatin as an induction therapy, is at least comparable or superior to hormone therapy in terms of efficacy.

Adenocarcinoma↗
PubMed1987

[Clinical studies on 61 patients with post-renal acute renal failure caused by ureteral obstruction].

The clinical course of 61 patients with post-renal acute renal failure caused by ureteral obstruction seen between January, 1976 and December, 1985, was studied retrospectively. Twenty of the patients were men between 55 and 85 years old, and 41 were women between 35 and 82 years old. In 50 of the 61 patients, uremia was caused by ureteral obstruction secondary to malignant tumors, and in 11, it was secondary to benign diseases. We divided the patients into two groups, those with primary malignant tumors and those with benign diseases. The location of the primary tumors in the malignant group was the genital system in 28 patients, upper gastrointestinal tract in 7, colorectum in 12, the urinary system in 2, and one was unclear. The benign group included 4 with urolithiasis, 3 with pelviureteral junction stenosis, 3 with post-operative ureteral stricture, and 1 with bilateral ureteral ligation due to operation error. Urinary diversion or reconstruction was performed on 56 of the 61 patients; bilateral nephrostomy in 6, unilateral nephrostomy in 16, bilateral ureterocutaneostomy in 8, unilateral ureterocutaneostomy in 11, unilateral nephrostomy with contralateral ureterocutaneostomy in 2, ureterolithotomy in 2, pyeloplasty in 2, ureterovesiconeostomy in 1, and insertion of a ureteral stent in 8. Of the remaining 4 patients 3 were treated by hemodialysis, and the other patient refused treatment. There was no significant difference in recovery of renal function between those patients undergoing only unilateral diversion and those undergoing bilateral diversion.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗
PubMed1986

[Use of arterial infusion of neocarzinostatin with or without combination chemotherapy as a treatment of carcinoma of the prostate].

Prostate cancer patients were treated with a basic therapy of intra-arterial injection of neocarzinostatin (NCS). This therapy was divided into three types of regimen: NCS intra-arterial injection alone, NCS intra-arterial injection + diethylstilbestrol (DES), and NCS intra-arterial injection + aclacinomycin A (ACR) + peplomycin (PEP). A comparative study was carried out on the clinical efficacies of these three regimens, and at the same time an investigation was made of the prognosis in the cases receiving NCS intra-arterial injection alone and NCS + DES. The clinical efficacy was found to be high in each of the three treatment groups in terms of subjective symptoms and laboratory findings, except for ALP. In the evaluation of efficacy on the basis of histological findings, the rates were 60.0% for NCS intra-arterial injection alone, 71.4% for NCS + DES, and 88.2% for NCS + ACR + PEP. Thus, all three of these treatment regimens gave good efficacy rates, but it is especially noteworthy that the combined chemotherapy regimen yielded the highest efficacy rate. On the other hand, the incidence of adverse reactions was much higher in the case of the combined chemotherapy regimen than in the other two regimens. In the patient group administered the NCS intra-arterial injection alone, the one-year survival rate was 75.0% and the 4-year survival rate was 25.0%, while in the NCS + DES treatment group the one-year survival rate was 87.5% and the 4-year survival rate was 37.5%. For individual patients, the correlation between the clinical efficacy and the prognosis was not strong. However, it was concluded that all three of the chemotherapy regimens are useful as forms of remission induction therapy.

Aclarubicin↗
PubMed1986

[Oral administration of 5-fluorouracil (5-FU) with intravesical chemotherapy as prophylaxis against recurrence of superficial bladder tumors].

The oral administration of 5-FU together with the intravesical instillation of carboquone and cytosine arabinoside was attempted in cases of superficial bladder tumor for the purpose of prophylaxis against postoperative recurrence. The recurrence rate in 25 patients treated by this intravesical chemotherapy and oral 5-FU administration was 9.1% after one year, 14.0% after two years and 27.8% at three to five years. The recurrence rate in 13 patients with intravesical chemotherapy alone was 8.7% after one year, 31.5% after two years and 58.9% at three to four years. The recurrence rate in six patients with oral 5-FU administration alone was 18.2% after one year, 41.6% after two years and 100% after three years. These results suggest that oral administration of 5-FU in combination with intravesical chemotherapy is useful as prophylaxis against recurrence of superficial bladder tumors.

Administration, Intravesical↗
PubMed1986

[The treatment of an impotent male with venous leakage].

The intracavernous pressure to produce a passive erection was recorded in a 40-year-old man suffering from impotence. The patient had passive erection with a flow of 160 ml/min. The flow needed to maintain erection was 40 ml/min. The pressure in the flaccid state was 15 mmHg, and 151 mmHg in the state of erection. In the state of erection, the perfused liquid was demonstrated to escape through the deep dorsal vein of the penis. No other causes of impotence were revealed, and we diagnosed his erectile failure to be due to venous leakage. We performed ligation of this vein. After the operation, nocternal penile tumescence was improved. His potency recovered completely, and no complication was noted.

Erectile Dysfunction↗
PubMed1985

Further studies on specificity of red cell adherence test: nonmalignant bladder lesions.

Specific red cell adherence test for blood group antigens was utilized in 32 nonmalignant bladder lesions, none of which was associated with bladder cancer, to determine the specificity of this test. All of the 14 lesions of cystitis cystica, cystitis glandularis, and chronic cystitis retained their antigens. Of the 18 lesions of squamous metaplasia, 13 (72%) were antigen positive. Testing for blood group antigens showed an overall 84 per cent specific rate in 27 of the 32 nonmalignant bladder lesions.

ABO Blood-Group System↗
PubMed1985

[Obstructive renal failure in patients with terminal malignant tumors--unilateral relief of ureteral obstruction and recovery of renal function on the opposite side].

In obstructive renal failure in patients with terminal malignant tumors, we relieved the obstruction on only one side. As a result, it was found that the renal function of the other side also recovered (in five out of 19 patients 26.3%). Therefore, obstructive renal failure in these patients was caused not only by direct obstruction by the tumor, but also by renorenal reflex, humoral factors such as uremic toxius and edema of tissues around the ureter. It would be correct to assume that a reversible mechanism, such as ureteral stent insertion, percutaneous nephrostomy, etc. Should first be selected, rather than permanent urinary diversion.

Adult↗
PubMed1983

[Studies on the use of computers at the Department of Urology. 3. Practice of dialysis and auxiliary therapeutic system at the dialysis room].

The recent development of blood purification methods is remarkable. Now the physician can choose a different method and apparatus for blood purification according to the condition of each patient. Unlike the days when a uniform therapeutic method was used on all patients, the method and apparatus used on each patient may differ, and therefore if an inappropriate method or apparatus is used, it may result in a serious medical error. Patients on dialysis are in a pathologic state brought about by the causative disease and that brought about by renal failure which can not be cured by blood purification therapy. Therefore, it is necessary to accumulate a large amount of information on the patient's condition, including tests, and to use them effectively to provide optimum management of the patient. The author developed a system to collect and analyse large amounts of such information by using a microcomputer to help improve the practise of dialysis, and enable more appropriate patient management. The input of this system are basic data on the patient, information relating to dialysis treatment, symptoms of the patient, results of tests, treatment applied etc.; its output are medical bills, drug requisition sheet, dialysis record etc. Simultaneously, the various pieces of information stored by this system can be retrieved as required. The planned objective of this system has been achieved in the past 8 months.

Computers↗