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Biomedical subjects

A Ignaszewski

Publications and source records attributed to A Ignaszewski.

7 recordsLinked to original sources

Exercise stress testing. An overview of current guidelines.

Exercise stress testing (ET) is an inexpensive noninvasive tool that provides valuable cardiopulmonary information in healthy and diseased populations. It is most commonly used for diagnosing coronary artery disease (CAD) and developing appropriate exercise prescriptions (EP). With its widespread use and application, it is imperative that safe and appropriate guidelines and procedures are used, as there are a number of risks associated with testing in a population with or suspected of having CAD. The focus should be on the patient's safety: personnel must be properly trained and aware of all emergency procedures, contra-indications for ET and indications for test termination must be strictly adhered to. Three main types of testing are prevalent: submaximal, maximal and maximal utilising gas exchange. The maximal test is most commonly used, and the submaximal is appropriate for hospitalised patients. Gas exchange data is essential when assessing congestive heart failure and timing for heart transplantation. ET is commonly performed using a treadmill or a bicycle ergometer. The treadmill provides a more familiar exercise modality and has been shown to have greater diagnostic sensitivity than the bicycle ergometer; it is, however, more expensive and requires more space in the testing room. The bicycle ergometer is more appropriate for those individuals who are severely obese or have problems with extended periods of walking. Regardless of the modality used, an appropriate exercise protocol should be used. In North America, the Bruce protocol is the most common. However, the Bruce protocol, and others that estimate exercise capacity based on equations, tend to overestimate exercise capacity. They may be too demanding for those with limited exercise capacity, and too long for those with high exercise capacity. For these people, an exercise protocol that reaches maximal capacity in 8 to 12 minutes using smaller increments in workload should be considered. Once completed, the results of ET needs to be correctly interpreted. This includes reviewing the test results while considering the patient's history, medications and indication for the test. ET can also be used to develop an EP for the participant. An EP should take into account the intensity, modality of exercise, frequency and duration, as well as being realistic for the individual and the goals to be achieved. All the information from the test results and the pre-test examination should be presented in a report that also includes the advised EP.

British Columbia↗

The need for revascularization procedures will decrease dramatically in the next decade.

Coronary revascularization, first with coronary artery bypass graft (CABG) surgery and later using percutaneous transluminal coronary angioplasty (PTCA), has been available as a treatment procedure for patients with anginal syndromes for over three decades. During this time, the number of procedures performed has risen exponentially. The most recent development has been the growing trend away from CABG towards PTCA. Despite these facts, it is argued that the need for coronary revascularization will decrease over the next decade and the reasons that underlie this provocative prediction are discussed. Scientific (both pathophysiological and epidemiological) and historical precedent with other surgical procedures that have disappeared completely from medical practice are used to substantiate this argument.

Angioplasty, Balloon, Coronary↗

Changing practice patterns in the management of acute myocardial infarction complicated by cardiogenic shock: elderly compared with younger patients.

BACKGROUND: Cardiogenic shock continues to be an ominous complication of acute myocardial infarction (AMI). Evidence from retrospective analyses, registries and observational studies suggests that aggressive management using emergent revascularization strategies can bring about significant improvement in survival in this setting. Several studies have identified age as an independent predictor of survival. OBJECTIVE: To study retrospectively the possible changes in practice patterns in the management of patients with AMI complicated by cardiogenic shock in a tertiary care referral centre, and to determine what effect these changes may have had on survival of the patients, stratified by age. METHODS: From 1989 to 1995, 115 patients fulfilled the study criteria of cardiogenic shock based on pump failure and of presenting within 48 h of onset of shock. Prespecified data were extracted from medical records. All available coronary angiograms (n = 72) were analyzed by two experienced angiographers and consensus of findings was obtained. RESULTS: The study revealed a significant increase in the use of cardiac catheterization, interventional procedures and intra-aortic balloon pump (IABP) support in patients in the age groups 65 years or less, 66 to 75 years, and older than 75 years in 1989 to 1990, through 1991 to 1992, to 1993 to 1995. Significantly fewer patients aged older than 75 years received cardiac catheterization, coronary intervention and IABP support throughout the study period and even in the final period analyzed. In-hospital survival improved from 4% in 1989-90 to 33% in 1991-92, and 44% in 1993-95 (P = 0.001). Patients aged 65 years or less improved from 10% in 1989-90 to 59% in 1993-95 (P = 0.032). Only 20% of patients aged older than 75 years survived in the 1993-95 period. By univariate analysis, use of coronary angiography (catheterization 46% versus no catheterization 5%; P < 0.0001), coronary intervention procedures (percutaneous transluminal coronary angioplasty or coronary artery bypass grafting) (intervention 48% versus no intervention 9%; P < 0.0001) and IABP support (IABP 41% versus no IABP 18%; P = 0.0096) were all associated with improved in-hospital survival. Use of thrombolytic therapy showed possible survival benefit only in patients aged older than 75 years (thrombolysis 33% versus no thrombolysis 5%; P = 0.10). Patients who underwent coronary intervention were younger (P = 0.002), had a lower incidence of previous myocardial infarction (P = 0.0002), lower heart rate (P = 0.04), higher peak creatine phosphokinase (P = 0.04) and fewer vessels with at least 70% stenosis (P < 0.0001). On multivariate analysis only lower age, lower heart rate and presence of coronary intervention procedures were found to have an independent effect on survival. CONCLUSIONS: Use of invasive treatment strategies has increased significantly since 1989-90 in the management of patients with AMI complicated by cardiogenic shock. This increase has been associated with improved in-hospital survival in all age groups except possibly the very elderly. Patients undergoing coronary interventional procedures are significantly different in baseline clinical characteristics from patients not undergoing these procedures. These observations underscore the need for randomized trials to define the optimal treatment strategies in these patients. Efficacy of invasive treatment strategies in elderly patients aged older than 75 years-deserves special attention.

Age Factors↗

Staphylococcus aureus pericarditis with tamponade complicating coronary angioplasty and stenting.

Infectious complications of coronary angioplasty and stenting are uncommon. A 70-year-old man is presented who underwent percutaneous transluminal coronary angioplasty (PTCA) and stenting of an occluded left anterior descending artery. This was complicated by Staphylococcus aureus pericarditis with tamponade. He was successfully treated with a closed drainage and antibiotics. This is the first reported case in the literature that documents purulent pericarditis and tamponade following percutaneous revascularization.

Aged↗

Assessing appropriateness of treatment: a case study of transplantation in older patients with congestive heart failure.

OBJECTIVE: To evaluate the appropriateness of transplantation therapy for older patients with congestive heart failure (CHF). DATA SOURCES: Comparative review of contemporary survival and quality of life data of CHF patients treated medically versus by transplantation. DATA SYNTHESIS: Approximately 300,000 Canadians have CHF and the incidence is increasing as the population ages; suitable donor allografts are found for about 300 CHF patients each year. Overall survival among cardiac allograft recipients, with a mean age of 48 years, is approximately 80% at two years. However, risk from all causes appears higher, and survival lower (range 40 to 78%), for transplant patients 55 years of age and older. Among medically treated patients, with mean age over 60 years, survival is inversely related to level of functional disability, averaging more than 90% at two years for patients with mild limitation and decreasing to 75% and 40% for patients with moderate and severe symptoms, respectively. Perceived quality of life is low in all CHF patients, but is significantly improved by intense out-patient care and education, irrespective of medical or transplant allocation. CONCLUSIONS: Among adults with CHF, the greatest benefit of transplantation is enhanced survival in younger severely disabled patients. However, noncardiac risks are substantial, particularly for older recipients. The great discrepancy between donor and candidate availability prohibits transplantation from being a life expanding therapy for the whole CHF population. When physicians are, simultaneously, patients' and society's advocates a utilitarian decision model using the totality of efficacy data, including degree of efficacy and population effectiveness, may assist determination of the most appropriate therapy.

Activities of Daily Living↗

The psychology of men and women recovering from coronary artery bypass surgery.

BACKGROUND: Little is known about the differences between men's and women's cardiac rehabilitation processes. What helps men during recovery may not necessarily aid women's recovery. Psychosocial variables are known to impact recovery in positive and negative ways. Unfortunately, it is not clear what variables are the most effective predictors of recovery outcomes for men and women. METHODS: Ninety coronary artery bypass graft patients (60 men, 30 women) completed a battery of psychological questionnaires on or after the third day after surgery. RESULTS: Results showed that women reported significantly more depressive symptoms than men. For women, pain was correlated positively with depressive symptomatology and functional impairment. For men, pain and functional impairment were correlated negatively with social support. In addition, the results of a multiple regression of pain on age, severity of disease, and two psychosocial variables (depressive symptomatology and social support) for the women showed that after controlling for age and severity of disease, depressive symptomatology and social support accounted for a significant 43% increment in the variance in pain. The psychosocial variables accounted for much less variance in pain in men. However, in a multiple regression of functional impairment on the same variables, depressive symptomatology and social support accounted for a significant 14% increment in the variance in pain in men but a nonsignificant increment for the women. CONCLUSIONS: The results support the notion that psychosocial variables play different roles in the recovery paths of men and women. In consequence, cardiac rehabilitation programs would be more effective with gender-specific tailoring.

Aged↗