In rabbit experiments, the local administration of prostaglandins E2 and F2 alpha provoked an increase in intraocular pressure because of hyperproduction of intraocular liquid and increased permeability of the histoophthalmic barrier. Local administration of dicinon and taurin elicited a protective action and prevented the hypertensive effect of prostaglandins. Dicinon and taurin did not produce any influence on spasmogenic and hemodynamic effects of prostaglandins on isolated preparations of smooth muscle organs. Therefore, the protective effect of the drugs in the prostaglandin-induced hypertension of the eye is not related to the antiprostaglandin properties shown by these drugs.

Animals↗

PubMedDate not supplied

[Perfusion pressure in ocular vessels of patients with open-angle glaucoma].

Perfusion pressure in ophthalmic vessels was measured by computer-aided ophthalmodynamography in health, stenoses of the internal carotid artery, and open-angle glaucoma. A total of 70 subjects were examined. Stenoses of the internal carotid artery are associated with a noticeable reduction of perfusion pressure on the side of stenosis. Some patients develop optic nerve atrophy (without excavation). Secondary neovascular glaucoma was diagnosed in 1 patient. Primary open-angle glaucoma was revealed in none of the patients. Increase of intraocular pressure in patients with open-angle glaucoma was associated with a reduction of perfusion pressure. However, in more than 50% of patients a higher pressure was observed in the orbital artery corresponding to the eye with a higher ophthalmic tone than in the contralateral eye. This was conducive to a certain leveling of perfusion pressure. Such a reaction is regarded as a manifestation of autoregulation of ocular vessels, important for blood delivery to the eyes.

Adult↗

PubMedDate not supplied

[New directions in the hypotensive therapy of open-angle glaucoma (experimental and clinical research)].

Clinical use of eye drops of a hybrid beta-alpha-adrenoblocker OF-4680 to reduce intraocular pressure has shown a high efficacy of the drug, not inferior to thymolol, for local hypotensive therapy of open-angle glaucoma. A combination of thymolol with taurin helped reduce the inhibiting effect of the beta-blocker on chamber humor secretion and simultaneously enhanced its discharge. The results evidence the desirability of correcting glutathion deficiency, detected in the patients with narrow-angle glaucoma, by lipoic acid.

Adrenergic beta-Antagonists↗