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Biomedical subjects

A I Zotin

Publications and source records attributed to A I Zotin.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Evolutionary bioenergetic trap and progressive evolution of animals].

We propose a macroscopic pathway to increase energy metabolism during progressive evolution with reducing size of animal body. If standard metabolism significantly increases in the course of body size reduction through increased coefficient b from the allometric equation (1), two cases are possible: coefficient b remains constant (1) or returns to the normal value (2) at increasing body weight in a given animal group. In the first case, an animal group appears in an evolutionary trap considering possible increase in body size, since the standard metabolism at increasing weight becomes lower starting from a certain point as compared to other animals of the same type. In the second case, increasing body size elevates standard metabolism relative to other animals of the same type, which offers an evolutionary advantage to this group.

Animals↗
PubMedDate not supplied

[Standard metabolism and macrotaxonomy of crustaceans].

The influence of temperature and other environmental factors on the rate of oxygen consumption has been studied in adult forms of crustaceans. The allometric relationship between respiration and body weight was calculated for 15 crustacean orders on the basis of published data on the standard metabolic rate and body weight in 225 crustacean species. The macrotaxonomy of the studied crustacean orders was proposed on the basis of the obtained values of coefficient a from the allometric relationship.

Adaptation, Physiological↗
PubMedDate not supplied

[The mitochondrial theory of carcinogenesis].

This is a brief review of different ideas on the mechanism of cell malignization united by the mitochondrial conception of carcinogenesis. According to this conception, primary trigger factors of carcinogenesis (free radicals, carcinogens, heat fluctuations) induce damage to mitochondrial DNA and membranes that results in the rearrangement of cell energy metabolism to glycolytic type and disturbance of mitochondrial structure and reproduction. The injured part of mitochondrial DNA incorporating into nuclear DNA induces activation of oncogenes, appearance of oncoproteins and malignization of cells.

Cell Transformation, Neoplastic↗
PubMedDate not supplied

[The macrosystematics of mammals according to energy metabolism criteria].

Criteria of evolutionary progress and complexity of organization have been proposed on the basis of the data on energetic metabolism. These criteria can serve as a basis of macrosystematics of mammals at the level of orders. The orders with the known data on energetic metabolism have been ranged.

Animals↗
PubMedDate not supplied

[Energy metabolism and the direction of evolutionary progress in the class of mammals].

The data on dependence of standard metabolism on body weight in 518 mammalian species have been summarized. Standard metabolism differs in representatives of different classes and families. The higher it is, the more complicated is the organization of the animals. Comparison of standard metabolism in different classes of mammals with the time of their paleontological origin demonstrates that evolutionary process in mammals was directed towards the increase in energetic metabolism of animals.

Animals↗
PubMedDate not supplied

[The lifespan and Rubner constant at different temperatures in Drosophila melanogaster].

According to the Rubner's hypothesis, the total amount of oxygen consumed during life is constant for animals. This value is designated as the Rubner constant. Experimental data on the energetic exchange and life span in D. melanogaster allowed to conclude that the total oxygen consumption during the imaginal stage and during the whole ontogeny was not constant and changed under the influence of environmental temperature factor.

Animals↗
PubMedDate not supplied

[A method for determining optimal development conditions by summary oxygen consumption].

The minimal overall oxygen consumption at a given developmental stage corresponds to the most favorable temperature conditions of development of poikilothermic animals. Theoretical considerations and experimental data are provided which substantiate this method of determination of the optimal developmental conditions and critical comments are analyzed.

Animals↗
PubMedDate not supplied

[Changes in the surface area and shape of growing organisms].

Equations describing the changes in body surface area of rats and humans during ontogenesis are proposed. A function of difference between the body surface and the surface of sphere of similar weight and density was chosen in order to characterize the body plan formation. Equations describing these processes in rats and humans are proposed.

Animals↗
PubMedDate not supplied

[Respiration and heat production in the embryonic development of chickens].

A marked increase in the rate of oxagen consumption and heat production, measured by the direct method, is observed in the chick embryogenesis. The intensity of respiration and heat production of the embryos decreases as the development proceeds. During development the data obtained by direct and indirect calorimetry diverge. This divergence, referred to as psi u-function, gradually decreases by the moment of hatching. Differences in the value of heat production and psi u-function were found in crosses of meat and egg directions, related to differences in the growth rate and productivity of adult fowl.

Animals↗