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Biomedical subjects

A I Volegov

Publications and source records attributed to A I Volegov.

At least 19 recordsLinked to original sources
PubMed2001

[The effect of low-energy laser radiation and interferon to delay chemical carcinogenesis].

A significant delay in benz(A)pyrene-induced tumorigenesis was obtained following three series of parenteral injection of xenogenic leukocytic interferon alternating with irradiation at 3-4 day intervals. Radiation was delivered from a red low-energy laser through a puncture in the peritoneal wall of the spleen. When each of said procedures was performed separately similar effects were recorded but the changes were not significant.

Animals↗
PubMed1984

[Effect of the combined use of BCG, PPD, a protein-containing preparation from allogenic tissue and cyclophosphamide in the development of methylcholanthrene-induced tumors].

The organism resistance to the appearance of 20-methylcholanthrene-induced tumours may be enhanced by application of different immunologic factors (BCG, PPD, low-molecular allogenic protein) in combination with a single administration of cyclophosphane (CPh). The positive effect was observed both when CPh was applied prior to the immunologic impact (3 or 7 days before) and after it (3 or 8 days later). In the last case the effect was more stable.

Animals↗
PubMed1981

[Changes in resistance to tumor development in various strains of mice exposed to immunologic agents during the neonatal period].

In the course of exposures to the immunological agents (BCG, complete Freund's adjuvant) during the postnatal period, the resistance to tumor development induced with chemical carcinogens was found to increase in C57BL/6 mice, particularly in BALB/c and random-bred ones; meanwhile in C3H/He mice it declined. At the same time C3H/He mice showed a decrease in the resistance to the development of spontaneous tumors of the mammary glands. The changes recorded correlated with those seen in the immunocompetent organs.

Animals↗
PubMed1980

[Certain features of the immune response in the presence of a tumor process].

Animal experiments have shown that in the presence of tumor growth immunological stimuli can produce shifts in some reactivity characteristics of the affected organism, which are the reverse of the shifts occurring in a healthy organism under similar conditions. This is attributed to the fact that the immunological stimulus used in these experiments (complete Freund adjuvant) was excessively strong for the affected organism, thus causing the suppression of certain components of reactivity instead of their stimulation. This mechanism is supposed to induce the suppression of the ptocesses lying at the basis of enhanced tumor growth; nevertheless, this suppression is not considered to have a significant positive effect.

Animals↗
PubMed1979

[Resistance of BCG-vaccinated body to tumor growth after administration of cyclophosphamide and desensitization].

It was shown that tumor growth is intensifying as a result of tumor cell implantation not only in early sensitization of BCG-vaccinated organism (see previously published data) but at the later period as well. Cyclophosphan removed this effect whereas desensitization carried out against the background of cyclophosphan action restored it. The data on the relationship between tuberculin allergy and the state of immunological defence reactions of the body suggest the possibility of stimulation of tumor growth as well as of its inhibition.

Animals↗
PubMed1978

[History of the foundation of the Moscow P.A. Gertsen Research Institute of Oncology].

The Moscow Oncology Institute was opened on November 18 (December 1) 1903 and named "Institute for Treatment of Malignant Tumors at Moscow University". With the lapse of time this name was changed several times. In 1947 it was named after a prominent Soviet surgeon P.A. Herzen. It is the oldest in Russia and one of the oldest in the world institutions for oncology researches.

Academies and Institutes↗
PubMed1978

[Changes in the resistance of different strains of mice to tumor development in the presence of immunologic responses].

The experiments on adult mice of varions breed lines have shown that direction of change of the resistance to cancer under conditions of the same immunological influence can be determined by genetic properties of an organism. The author believes that it is worthy of attention that anticancer resistance decreases only in that lines of mice in which was observed some predisposition to appearing of condition of allergy to tuberculine, as it was shown in experiments using the full adjuvant of Freund.

Animals↗
PubMed1977

[Antitumor resistance in depositing Mycobacterium tuberculosis in the lungs of rats].

In the experiments on rats of "Wistar" line and non-inbred rats the author has demonstrated that the inflammatory process in the lungs induced by non-virulent mycobacteria of BCG strain is able to decrease the organism resistance to the occurrence of chemically induced tumors. Desensibilization with PPD prior to the appearance of tumors would contribute to restoration of their antitumor resistance.

Animals↗