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Biomedical subjects

A I Tentsova

Publications and source records attributed to A I Tentsova.

At least 19 recordsLinked to original sources
PubMed1990

[Pharmacological availability of erythromycin granules for children's use].

Pharmaceutical availability of erythromycin granules with polymeric coating of different composition+ was studied. With an account of the ++anatomo-physiological features of a child organism and the properties of the antibiotic, acetylphthalyl cellulose in combination with hydroxypropyl methylcellulose or methyl cellulose was used as a film forming agent. The coated granules were estimated by such parameters as the time of disintegration and the rate of dissolution in various media. The results of the study showed that coating of the erythromycin granules with the film composed of acetylphthalyl cellulose and hydroxypropyl methylcellulose in the ratio of 8 to 2 provided the required protection of the antibiotic in acid media and high pharmaceutical availability of the drug.

Drug Evaluation, Preclinical↗
PubMed1984

[Production of liposomal preparations of streptomycin and dihydrostreptomycin].

The effect of the conditions of the formation of liposomal preparations of streptomycin and dihydrostreptomycin on incorporation of the antibiotics into the liposomes was studied. The liposomes were obtained with the detergent (cholate) method modified by the authors. The modification implies preliminary application of a 20 per cent antibiotic buffer solution on columns for gel filtration of a mixed mycellar antibiotic solution (20 per cent). The volume ratio of the preliminary applied buffer solution and the mixed mycellar solution is higher than 4:1. The new procedure is simple, readily reproduced, providing formation of the liposomal preparations characterized by high levels of the antibiotic incorporation (about 300 micrograms per 1 mg of lecithin). The preparations are stable with regard to the antibiotic release. The liposomes do not aggregate on storage for a long period (more than 6 months). The liposomal preparations thus formed may be useful as intravenous dosage forms of the antibiotics.

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