Biomedical subjects
Publications and source records attributed to A I Sukhodolia.
The gastric secretion inhibition, the second phase mainly, after the extragastric vagotomy (EGV) conduction, was proved in experiment. The inhibition of carbacholine and more profound (up to 92%) of pentagastrin secretion was noted. In 42 patients with duodenal ulcer disease the EGV was performed.
There were examined 79 patients, operated on for duodenal ulcer disease. Before the operation the Helicobacter pylori (HP) dissemination of stomach and duodenum of significant degree was diagnosed in 51.9%, mild degree--in 34.2% and of a nonsignificant one--in 13.9% of patients. After the operation the HP dissemination of stomach and duodenum had persisted.
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The gastric function indexes (basal secretion, the pentagastrin and insulin tests) is one of the main criteria for choosing the organ-preserving operation method. In 162 patients with duodenal ulcer disease there were performed the isolated selective proximal vagotomy (SPV), SPV with draining operation, extragastric vagotomy with draining operation, selective vagotomy with antrumectomy, SPV with disconnection of antrum and gastric corpus.
In chronic experiments on dogs with gastric fundus fistula it was established that the isolated vagotomy of greater curvature had promoted the substantial reducing of gastric secretion, stimulated by insulin, pentagastrin, carbachol and histamine.
The small intestine vagotomy influence on gastric secretion function, stimulated by pentagastrin and carbachol, was investigated while chronic experiment on dogs with gastric fundal and duodenal fistulas. The comparative analysis of influence of extragastric selective proximal, selective distal, selective and truncal vagotomy on gastric secretion in various terms after operative intervention was also conducted. In 6 months after conduction of various kinds of vagotomy the reduction of hydrochloric acid secretion, stimulated by pentagastrin, was noted.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.