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Biomedical subjects

A I Spriggs

Publications and source records attributed to A I Spriggs.

18 recordsLinked to original sources
PubMed1978

Women with positive cervical smears but without surgical intervention. A follow-up study.

By a collaborative effort among British cytopathologists, 101 women were identified who had had unsuspected "positive" cervical smears but who, after at least 2 years, had still escaped biopsy through refusal, default, or failure to trace. Of these, 31 still could not be traced; 10 were traced but could not be further examined (8 because they refused); 7 had clinically diagnosed carcinoma of the cervix; and the remaining 53 had further smears and/or biopsies after a mean interval of 5.2 years. In 19 of the 53 the smear had become negative or biopsy showed no lesion. Regression was confined to women aged under 40 at the time of the initial positive smear. In 20 cases biopsy showed dysplasia or carcinoma-in-situ, in 3 microinvasive carcinoma, and in 3 occult invasive carcinoma. Of the 7 women who presented clinically with carcinoma of the cervix, this caused death in 5.

Adult↗
PubMed1978

Joint fluid cytology in Reiter's disease.

The diagnostic value of the finding of cytophagocytic macrophages (CPM) in the joint fluid of patients with Reiter's disease has been re-examined. CPM were found in 46% of Reiter's disease fluids and in 45% of other inflammatory knee joint fluids. Higher CPM scores, on a 4-point grading, were commoner in Reiter's disease but the difference was not statistically significant. Further, although the graded polymorphonuclear leucocyte phagocytosis shown by CPM was greater in Reiter's disease this also was not significant. It is concluded that the presence of CPM in joint fluid is of little discriminating value.

Arthritis, Reactive↗
PubMed1977

Cervical smears.

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Adolescent↗
PubMed1976

Adenocarcinoma of the uterine cervix: cytological evidence of a long preclinical evolution.

Adenocarcinoma of the cervix occurred in 13 women who had previously had "negative" cervical smears. These smears were reviewed, and abnormalities were found in six cases, the intervals ranging from two to eight years. It is concluded that adenocarcinoma, like squamous carcinoma of the cervix, can have a prolonged evolution during which it is cytologically detectable.

Adenocarcinoma↗
PubMed1976

Duplication of part of the long arm of chromosome 1 in marrow cells of a treated case of myelomatosis.

In a case of classical myelomatosis treated with melphalan, a clone of cells with a chromosomal abnormality was found in the bone marrow during remission. There was good reason to think that the hemopoietic cells, rather than plasmacytoma cells, were implicated. Although the clone persisted, no evidence of leukemia developed over a period of observation of 2 yr. The anomaly was interpreted as a duplication of part of the long arm of chromosome 1, which appeared to involve the segment q21 to q31.

Aged↗
PubMed1975

Intracellular mucous inclusions. A feature of malignant cells in effusions in the serous cavities, particularly due to carcinoma of the breast.

Three cases of carcinoma of the breast are described, in which similar tumour cells were found in pleural or peritoneal fluid. The cells were characterized by the frequent presence of 'bull's-eye' vacuoles, in which a central spot was deeply stained by Giemsa, eosin or periodic acid-Schiff (PAS). In one of these it was shown by electron microscopy that the vacuoles are lined by microvilli, and that their mucinous content is condensed in the central area, presumably as a result of failure to discharge the secretion.

Aged↗
PubMedDate not supplied

Letter: Microvilli.

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Adenocarcinoma↗
PubMedDate not supplied

Oat-cell bronchial carcinoma. Identification of cells in pleural fluid.

An analysis is made of the accuracy of diagnosing oat-cell (small cell) carcinoma of the lung from the cytology of pleural fluid. All the material over a 22-year period has been reviewed. Air-dried smears were used, stained with May-Grünwald-Giemsa. Of 91 cases in which oat-cells were specified in the written report, 90 were either proved histologically to have oat-cell or anaplastic bronchial carcinoma, or else had clinical findings consistent with that diagnosis and were registered as having bronchial carcinoma at death. There was one false positive, and no false suspicious reports. Cytologic diagnosis of this tumor type has, therefore, been no less reliable than would be expected from a histologist examining a surgical biopsy of infiltrated tissue. Of 49 consecutive cases histologically proved to have oat-cell carcinoma, and with pleural effusions examined in this laboratory, 21 showed no malignant cells (43 per cent false negative). Diagnostic features and causes of error are discussed, as well as the advantage of air-dried smears over the standard Papanicolaou method for the detection of this cell type.

Azure Stains↗