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Biomedical subjects

A I Sinopal'nikov

Publications and source records attributed to A I Sinopal'nikov.

At least 19 recordsLinked to original sources
PubMed2002

[Exacerbation of chronic obstructive pulmonary disease: current approaches to antibacterial therapy].

The article outlines current approaches to empiric antibacterial therapy of patients who had exacerbation of chronic obstructive pulmonary disease (COPD). The choice of the antibiotics should be made basing on the frequency of exacerbations, COPD duration, severity of bronchial obstruction, age of the patient, concomitant visceral lesions. Common errors in antibacterial therapy are analysed: wrong choice of the antibiotic, mode of drug administration, dose, dose regimen, duration of treatment (too long); simultaneous intake of antibiotics and nistatine; frequent change of antibiotics throughout the treatment.

Anti-Bacterial Agents↗
PubMed2001

[Severe community-acquired pneumonia: etiology].

A complex microbiological (sputum, protected brush biopsy of the bronchial mucosa) and immunological examination of 40 male patients (the average age of 55.4 +/- 8.8 years) with severe community-acquired pneumonia (risk classes III-V according to Fine M.J. et al., 1997) revealed the disease etiology in 52.5 per cent of the cases. The leading pathogen was Streptococcus pneumoniae. It was detected in 61.6 per cent of the cases of the etiologically verified pneumonia. Staphylococcus aureus and Klebsiella pneumoniae were also among the actual pathogens (14.3 and 14.3 per cent respectively). The Legionnaires infection was not confirmed in any of the patients (enzyme-linked immunological analysis of urine for the serotype 1-6 Legionella pneumophila antigen). In the absolute majority of the patients the isolated pneumococci were susceptible (E-test) to benzylpenicillin. Only in 1 patients with severe pneumonia and secondary bacteriemia the pneumococcal isolates were moderately resistant to benzylpenicillin (the MIC of 0.125 mg/ml). Still, they were susceptible to ceftriaxone (the MIC of 0.023 mg/ml). The data are useful in the development of a national (regional) programme for empirical antibacterial therapy of severe community-acquired pneumonia.

Bacteriological Techniques↗
PubMed2000

[Pharmacoeconomic aspects of therapy of pneumonia in a hospital].

In the article the assessment of hospital treatment cost of patients with pneumonia under conditions of district military clinical hospital is given. The analysis of cost of complete treatment course has shown that the most expensive is therapy of patients with severe and moderately severe pneumonia (6083 and 4608 rubles). Depending on pneumonia severity the treatment expenses increases on the average by 49%. The main treatment expenses in pneumonia under hospital conditions are medical-and-diagnostic, which determine the other items of expenditure.

Costs and Cost Analysis↗