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Biomedical subjects

A I Martynov

Publications and source records attributed to A I Martynov.

At least 19 recordsLinked to original sources
PubMed2001

[Changes in aortic elasticity in aged patients with essential arterial hypertension].

Aortic elasticity was studied in aged patients with mild and moderate arterial hypertension using magnetic resonance imaging. The analysis of changes in cross section area (CSA) of the ascending aorta in systole has shown that in some patients maximal CSA occurs in different systolic phases while in the other patients CSA remains unchanged. Calculation with the elasticity rate proved that patients with maximal aortic diameter at the beginning of the systole have maximal aortic elasticity while those with minimal changes in aortic diameter in the course of the systole have minimal elasticity. Thus, in aged patients with mild and moderate essential hypertension aortic wall loses its elasticity to different extent. Further studies will specify clinical and pathogenetic implications of reduced aortic elasticity in arterial hypertension.

Aged↗
PubMed2001

[Correction of sleep disorders and efficacy of antihypertensive monotherapy in elderly patients: use of ivadal].

AIM: To assess effects of ivadal (zolpidem) on arterial pressure (AP) in the cycle sleep-awake in aged patients with insomnia who have failed hypotensive monotherapy with different drugs, i.e. whose AP remained abnormal at night. MATERIALS AND METHODS: The trial included 25 aged patients (17 females, 8 males, mean age 66.4 +/- 3.7 years) with isolated systolic arterial hypertension (AH) of the first-second degree (WHO classification, 1999) and insomnia. AH duration averaged 8.7 +/- 3.7 years. All the patients have received antihypertensive monotherapy. As shown by the initial 24-h monitoring, patients with elevated night AP had significantly lower mean score by the questionnaire "Subjective Sleep Characteristics" and more frequently suffer from insomnia. These patients were given a hypnotic drug ivadal (zolpidem) in a single daily dose 5 mg in the evening for 10 days. On the treatment night 10 monitoring of AP was repeated. RESULTS: Ivadal treatment has significantly improved all the subjective parameters of sleep and 24-h AP profile, lowered sleep and awake AP. CONCLUSION: Ivadal treatment raises efficacy of a hypotensive monotherapy in aged patients with isolated systolic AH and insomnia.

Aged↗
PubMed2000

[Results of 24-hours arterial blood pressure monitoring in patients with mitral prolapse and anomalous chorda].

AIM: To examine 24-h arterial hypertension (AH) profile in patients with connective tissue dyplasia syndrome (CTDS). MATERIALS AND METHODS: 92 patients (35 males and 57 females) with CTDS aged 18-37 years. 68 had mitral prolapse stage I-II, of them 23 had anomalous chorda. 25 patients with vegetovascular dystonia (VVD) free of cardiac lesions. 24-h monitoring of arterial pressure was done in all the patients. RESULTS: Hypertensive load was higher in CTDS and VVD being the highest in patients with the prolapse. Incidence of arterial hypertension was similar in all the groups. CONCLUSION: CTDS patients have indications for 24-h monitoring of arterial pressure to reveal latent arterial hypertension and profile of arterial pressure. This will allow to predict complications of hypertension and prescribe relevant treatment.

Adolescent↗
PubMed2000

[New approaches to the treatment of patients with idiopathic mitral valve prolapse].

AIM: To assess efficiency of magnerot, magnesium orotate, in patients with idiopathic mitral prolapse (IMP). MATERIAL AND METHODS: 84 patients with IMP were randomized to the study group (43 patients) and control group (41 patients). Patients of the study group received magnerot tablets (Germany) containing 500 mg of magnesium orotate (daily dose 3000 mg) for 6 months. The examination performed before the treatment and 6 months after it included: modified clinical and phenotypic records, echocardiography, 24-h ECG and AP monitoring, spectral analysis of cardiac rhythm variability, evaluation of quality of life according to Visual Analog Scale and Disability Scale and of treatment results according to Clinical Global Impression scales, measurements of magnesium in the hair by plasmic nuclear emission spectrometry, histological and histochemical skin tests. RESULTS: IMP patients appeared to suffer from magnesium deficiency which is responsible for many symptoms in mitral prolapse. 6-month therapy with magnerot completely or partially reduced the symptoms in more than half the patients. Positive changes were registered primarily in clinicofunctional manifestations. Morphological changes in the skin correlating with the disease severity alleviated. CONCLUSION: Good objective and subjective response to magnerot 6-month therapy (3000 mg/day) is demonstrated.

Adult↗