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Biomedical subjects

A I Krotov

Publications and source records attributed to A I Krotov.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[The structure and anthelmintic action of tricyclic analogs of praziquantel and 4-acylpiperazinones-2].

The toxicity and anthelminthic activity of the earlier synthetized tricyclic analogues of praziquantel and 4-acylpiperazinones-2 have been studied. Tricyclic compounds have shown the acute toxicity similar to that of praziquantel and neurotoxic effect typical of praziquantel. 4-acylpiperazinones-2 toxicity correlated with their anthelminthic effect. The determination of anthelminthic activity of the above compounds in opisthorchiasis and hymenolepiasis has shown that they are less effective than praziquantel or have no anthelminthic activity. A biological activity-structure relationship has been traced in the compounds under study.

Animals↗
PubMedDate not supplied

[Ways and methods of searching for new anthelmintics].

The ways of searching for new anthelminthic agents among diverse chemical compounds are analysed. The most promising chemical groups are presented. It is recommended to test every drug using as many as possible experimental models. For drug screening it is advisable to apply a multi-stage investigation method as the most economic and perspective one. The drug selection technique, experimental study procedure and ways of increasing anthelminthic efficiency are outlined.

Animals↗
PubMedDate not supplied

[Experimental chemotherapy of alveolar hydatid disease. 12. The efficacy of drug forms of mebendazole and nocodazole with high bioavailability].

New formulations have been designed to increase the efficacy and bioavailability of the oral drugs mebendazole and nocodazole and were tested in CBA mice. A considerable increase in efficacy was established for a solid disperse formulation of certain composition with a relatively lower toxicity than in aqueous suspensions of the drugs.

Administration, Oral↗