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Biomedical subjects

A I Khazanov

Publications and source records attributed to A I Khazanov.

At least 19 recordsLinked to original sources

[Current problems of viral and alcohol diseases of the liver].

517 cases of acute viral hepatitis (AVH) and 1203 cases of hepatic cirrhosis (HC) have been analysed. In recent 20-28 year the trend to a decline in the role of HBV infection in the origin of both AVH and HC. The least lethality was reported for viral C-cirrhoses. When the sale of heavy drinks was limited by the law, lethality of alcoholic hepatic cirrhosis came down 2.5-fold. Among hepatic cirrhoses, the percentage of alcoholic forms has increased from 35.6% in 1972-1984 to 41.5% in 1996-2000. The worst prognosis is now stated for alcoholic-viral and polyviral hepatic cirrhoses. The data for 4.5 years evidence for at least 50% lethality in this group.

Acute Disease↗

[Acute viral hepatitides].

The article describes the characteristics of the acute virus hepatitis A, B, C, D, E, F, G. The clinic aspects of the asymptomatic, cholestatic and fulminant forms of the disease have been examined. Have been reported in detail on diseases being a part of the group of atypical forms, about the preventive measures of the acute viral hepatic diseases.

Acute Disease↗

[Severe and complicated forms of chronic pancreatitis].

A total of 437 patients with chronic pancreatitis (CP) were examined. The authors detected interstitial or acute, parenchymal or recurrent, hyperplastic or pseudotumorous, and cystic variants in 91 (20.8%), 218 (49.9%), 78 (17.8%), 22 (5.1%), and 28 (6.4%) patients, respectively, Severe types due to the permanent pain syndrome, substantial weight loss and overall intoxication phenomena were seen in 21.5%. Complications of chronic pancreatitis were revealed in 32.3%. Pyoseptic complications (11.2%), anicteric cholestasis (8.5%), subhepatic portal hypertension (8.0%), cholestatic jaundice (7.8%) were most common. Immunodeficiency states developed with long-term treatment of CP. A small portion (0.9%) of patients with CP developed pancreatic carcinoma. 3% of patients had deaths directly due to the active course of the disease whose causes were pyoseptic processes, pancreatic carcinoma and profuse hemorrhages from exulcerations of the duodenal postbulbar part.

Adult↗

[The clinical picture and diagnosis of pancreatic carcinoma].

A total of 97 patients with pancreatic carcinoma were examined with sonography, computed tomography of the pancreas and endoscopy of the stomach and duodenum. The tumor involved mainly the head of the pancreas in 69 (71.1%), the body in 21 (21.7%) and the tail in 7 (7.2%) patients. Two basic types of the disease were identified: disseminated in 83 patients and rare in 14 patients. The disseminated type included a central (45 patients) and a peripheral (38 patients) variant. The latter is classed as peripheral (n = 30) and paraduodenal (n = 8). The rare types included masked variants (n = 6), miniblastomas (n = 3), megablastomas (n = 2) of the pancreas, as well as thrombotic variants of the disease (n = 3). The highest diagnostic value of sonography and computed tomography was observed in intrinsic peripheral variants of carcinoma. Gastroduodenal endoscopy along with biopsy of suspected segments is highly diagnostic in paraduodenal variants of the disease.

Biopsy, Needle↗

[Hepatitis B virus markers in the internist's practice].

Three various forms of contact or its consequences are recognized for hepatitis B virus and human body; acquired immunity to HBV, HBV persistence, HBV replication. Two forms of seroconversion (transfer of HBeAg into anti-HBe serum) are demonstrated. One of them occurs commonly and has a good prognosis, the other emerges rarely and runs a severe course likely to end in life-threatening complications.

Aged↗

[Recalling the war].

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History, 20th Century↗

[The classification of chronic pancreatitis].

To make the II Marseilles Classification of Pancreatitis more applicable to everyday clinical practice, a new systemic approach is suggested basing on clinical, laboratory, CT and ultrasound evidence. Upon examination of 182 chronic sufferers with pancreatitis, interstitial--edematous, parenchymatous, fibrous--sclerotic (indurative), hyperplastic (pseudotumorous) and cystic variants of the disease were established in 34.6%, 30%, 21.1%, 4.4% and 9.9%, respectively. Clinical features typical for each variant of the disease and most common complications are reviewed.

Chronic Disease↗