Search PubMed⌕ Search

Biomedical subjects

A I Gladkova

Publications and source records attributed to A I Gladkova.

At least 19 recordsLinked to original sources
PubMed1986

[Inhibin activity of the organs of the male reproductive system in rats treated with dihydrotestosterone].

The content of protein hormone, inhibin, in the rat testis and prostate has been studied on preadolescent female mice. Both organs were characterized by a certain inhibin activity, it being higher in the prostate. A single injection of 25 mu kg dihydrotestosterone (DHT) to rats has been followed by the increase in testicular and prostate mass, elevation of 17 alpha-hydroxyprogesterone and testosterone levels in peripheral blood, and a slight rise in inhibin testicular activity, with the lack of these changes in the prostate. The detection of inhibin in the prostate confirms possible direct link of the organ with the pituitary body. DHT effect on spermatogenesis has been but insignificantly related to FSH depression.

Animals↗
PubMed1986

[Physiologic basis for the "attractiveness" of female rats for males].

Sexual behaviour of intact male rats was studied in tests with ovariectomized female rats and with those injected with sexual hormones. The data obtained support the hypothesis of the existence of central and peripheral mechanisms regulating the sexual behaviour of male rats. The treatment of castrated females with androgen resulted in males sniffing at them mor often, the copulatory behaviour being only observed in tests with females treated with estrogens in combination with progesterone.

Animals↗
PubMed1984

[Morphologic and hormonal correlates of true hermaphroditism in the rabbit].

A macro-microscopical and histological investigation of the urogenital system organs of a rabbit-hermophrodite has been performed with an aim to compare the content of sex steroids in the peripheral and in the gonadal blood estimated by means of radioimmunological methods. Certain anomalies have been found out in the development of external and internal sex organs, kidneys and urinary bladder. Testosterone and estradiol concentration in blood flowing from the ovotestis is decreased, as it is in the periphral blood. The rabbit urogenital system organs have been studied from the 12th day of the intrauterine development up to the 10th day of the postnatal life. The results of the investigation performed make it possible to consider that the developmental anomalies in the rabbit-hermophrodite have, evidently, appeared between the 20th--25th days of its intrauterine development as a result of certain disbalance of sex steroids.

Animals↗
PubMed1979

The sympatho-adrenal system and sulfhydryl groups in the heart in experimental myocardial infarction.

In 59 sexually mature male chinchilla rabbits, and in control sham-operated animals, there were compared the indicators characterizing the functional state of the heart and the levels of catecholamines and of SH groups in experimental myocardial infarction induced by ligating the descending branch of the left coronary artery. Phasic shifts were found in the heart adrenergic regulation, dependent on the stage of infarction. In all animals in the acute stage of myocardial infarction the activity of the sympatho-adrenal system was enhanced. In an extensive transmural infarction and in cases with a lethal outcome the levels of total and protein-bound noradrenaline were lowered. The course and prognosis of experimental myocardial infarction were dependent on the degree of disturbance of formation of complexes of noradrenaline with adrenoreceptor structures, caused by decreases in the levels of noradrenaline and sulphydryl groups.

Adrenal Glands↗
PubMed1977

[Functional and structural changes in the adrenal cortex of rabbits under conditions of chronic inflammation of the prostate gland].

Investigation of the state of the rabbit adrenal cortex under conditions of depression of the incretory activity of the testicles resulting from chronic inflammation of the prostate showed progressive hyperplasia of the reticular zone of the adrenal cortex; as to the glomerular zone, it failed to display any marked pathological changes, and the fascicular zone demonstrated some signs of hypoplasia. Thus, the normal or elevated androgen excretion observed in the experimental male rabbits, was provided by an intensified activity of the reticular zone of the adrenal cortex, despite a decrease in testosterone biosynthesis in the testes.

Adrenal Cortex↗
PubMedDate not supplied

[The regulation of male sexual behavior by the sex hormones].

The article provides a review of the clinical and experimental data, both published and the author's own observations. They demonstrate that the hormone regulation of sex behaviour takes place at the central and the peripheral levels. The major role is played by androgenes, of which testosterone is the main regulator of sex appeal (libido, courtship behaviour in animals), while the most important regulator of ejaculation, in particular, of the time of ejaculation, is the non-aromatized androgene dihydrotestosterone (DHT). There is no rigid correlation between the level of sex activity and the level of androgenes, if the latter are within the normal individual and physiological range. However, both in case of hypo- and hyperendrogeny, the observations indicate depression of sexuality, though the mechanism of the depression are different. The author established the optimal levels of androgenes, which maintain the individual elements of the sexual act. The role of estrogene in regulation of the male sex appeal is not yet clear. As a rule, use of estrogenes results in depression of the male sexuality. At the same time, combination of DHT and estradiole (in laboratory and productive animals) leads to normalisation of erection and ejaculation disorders. These result is, probably, due to the central effect of estrogene, which prolongs the DHT effect and censures its accelerated penetration into cellular neuronal structures, as well as to the peripheral effect of DHT.

Androgens↗
PubMedDate not supplied

[The effect of grofollon on the induction of sex maturation in female rats].

The authors provide the results of experimental studies carried out in immature female rats given the gonadotropin grofollon to stimulate puberty. Grofollon was administered in doses of 20, 30 or 50 units. It was dissolved in a physiological solution or prolongon. The effect of grofollon was found to depend on the dose and type of the solvent. The earliest response (in 6 hours) to grofollon administration was marked by an increase of plasma estradiol. 24 hours after the hormonal treatment there was a rise of the mass of the ovaries and uterus, in particular. The vagina opened on the 3d day. The dissolution of grofollon in prolongon was discovered to enhance the drug efficacy.

Animals↗
PubMedDate not supplied

[Testosterone-inhibin interaction in male sterility].

The purpose of investigation was to define the role of hormones, circulating in the peripheral blood and contained in the seminal fluid of an ejaculate, in the pathogenesis of sterility. Men under 40 with a secretory type of sterility were investigated. A decrease in testosterone concentration with a high level of estradiol was observed in peripheral blood. Blood inhibin activity was low in healthy persons and in patients (though higher in the latter). LH and prolactin levels were raised in the absence of changes in FSH and cortisol concentrations. The level of testosterone in the seminal plasma was much lower than in peripheral blood whereas inhibin activity was higher in all examinees. Blood concentration of testosterone in healthy subjects and sterile patients was shown to have a positive correlation with the concentration of spermatozoa and their mobility. Testosterone concentration in the seminal plasma was reflected, to a lesser degree, in spermograms than in peripheral blood. The activity of circulating and seminal inhibin showed reverse correlation with the concentration of spermatozoa in healthy subjects; such a correlation in patients was observed only with blood inhibin. In the activity of spermatozoons negative correlation was observed in healthy subjects only. Disorder of the above correlation was revealed against a background of the high activity of inhibin that could determine sterility.

Adult↗