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Biomedical subjects

A I Autenshlius

Publications and source records attributed to A I Autenshlius.

At least 19 recordsLinked to original sources
PubMed2004

[The levels of T lymphocytes and thymic peptide antibodies in patients with infiltrative pulmonary tuberculosis and in those with cancer diseases].

A relationship of the levels of thymic peptide antibodies to those of the population and subpopulations of T lymphocytes was studied in patients with pulmonary tuberculosis, lung or breast cancer. Indirect immunofluorescence was used to determine the count of CD3-, CD4-, CD80, CD38-, CD25-, CD71-, and CD95-lymphocytes. The levels of thymic peptide antibodies were estimated by enzyme immunoassay. Unlike cancer diseases, pulmonary tuberculosis was characterized by the combination of a significantly inverse correlation between the relative count of CD3-, CD4-, CD8-lymphocytes the levels of thymogen antibodies with a significantly direct correlation between the absolute count of CD25- and CD38-lymphocytes. The studies may recommend that the levels of thymic peptide antigens should be determined to select persons with immunodeficiency particularly those with inflammatory diseases.

Antibodies, Bacterial↗
PubMed2004

[Antibodies to mycobacterial antigens in patients with pulmonary tuberculosis].

The levels of IgG and IgM antibodies to different mycobacterial antigens were studied in patients with varying pulmonary tuberculosis. The higher levels of IgG and IgM to the used antibodies were simultaneously found in patients with infiltrative tuberculosis as compared with healthy individuals. As compared to patients with fibrocavernous pulmonary tuberculosis, those with infiltrative tuberculosis had significantly lower levels of IgG antibodies to BGC sonicate and protein with a molecular weight of 40-70 kD isolated from the strain H37Rv. A correlation was found between the IgM antibodies to protein isolated from the strain H37RV and to H37RV sonicate and the degree of the activity unique to fibrocavernous pulmonary tuberculosis.

Adolescent↗
PubMed2003

[Levels of some cytokines in infants with central nervous system damage].

Two cytokines--interleukin 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) levels have been studied in infants with CNS damage of different severity. The more was the brain lesion severity, the higher the TNF-alpha level increased. IL-1 beta levels were reduced significantly in severe brain injury caused by hypoxia. Chronic hypoxia combined with intrauterine infection and/or a risk of the latter was accompanied by imbalance of IL-1 beta and TNF-alpha secretion.

Acute Disease↗
PubMed2002

[Quantitative characteristics of the cellular link of immunity and a lymphocytic response to tumor-associated antigens in patients with tuberculosis and malignant neoplasms of the lung].

The relative quantities of basic populations and subpopulations of lymphocytes and their response to tumor-associated antigens were estimated in the peripheral blood patients with tuberculosis and malignant neoplasms of the lung. In both diseases, the changes in the count of immunocompetent cells are similar and they characterize immunodeficiency typical of these conditions. A response to tumor-associated antigens was found only in patients with lung cancer, the pattern of this response depending on the grade of a tumor.

Antibodies, Monoclonal↗
PubMed2002

[Lymphocyte reaction and humoral immune response to brain specific protein in children with pathology of the central nervous system].

Blood lymphocyte reaction to brain specific protein (BSP) in vitro and anti-brain antibodies (AB) levels were studied in newborns and infants with perinatal central nervous system (CNS) damages of various severity. A relationship between severity of CNS damages and a lymphocyte reaction to BSP as well as immuno-regulative index (IRI) changes. A combination of high AB to BSP levels with IRI elevation after cells incubation with BSP was found to be a favorable prognostic sign. In contrast, IRI reduction combined with higher AB levels appeared to be an unfavorable one.

Antibody Formation↗
PubMed1995

[Antibodies to Bacillus megaterium H glycoprotein in patients with lung diseases].

Enzyme immunoassay performed in patients with malignant and benign affections of the lungs determined antibodies (Abs) to glycoprotein isolated from saprophyte microorganism Bacilus megaterium H. In pulmonary tuberculosis and nonspecific pulmonary inflammation the above Abs occurred in patients with fibrous-proliferative changes and associated neoplastic conditions. In lung cancer the Abs were detected in well and moderately differentiated tumors. Nondifferentiated and poorly differentiated variants did not exhibit any rise in Abs to glycoprotein.

Antibodies, Bacterial↗
PubMed1994

[Quantitative characteristics of immunity in patients with reactivated pulmonary tuberculosis].

Immune status was assessed in 44 patients with pulmonary re-infection tuberculosis using monoclonal antibodies. Quantitative indices of the immune status (relative amount of T-cells, T-helpers, T-suppressors, natural killers) correlated with tuberculosis activity. It is important to identify immunity-compromised subjects among tuberculous patients to rule out relapses with the help of early immunocorrection.

Adult↗
PubMed1991

[Determination of antibodies to cross-reacting antigens of microorganisms in oncological diseases].

It was studied antibodies to saprophytic microorganism Bacillus megaterium H glycoprotein in healthy, oncological, non-oncological gastrointestinal patients and animals. High level of antibodies to microbial glycoprotein in blood sera was revealed in cancer and precancer patients. Analogical results were obtained in mice A/Sn and Balb/c with inductive or transplanted tumors. It has been suggested the use of Bacillus megaterium H glycoprotein (M. m. 65-70 kD) for immunological monitoring.

Animals↗
PubMed1990

[Correlation between altered granulocytes and visualized brain anti gens in newborn infants with pathology of the central nervous system].

In order to reveal granulocyte sensitization in children with CNS pathology, use was made of the immunocytoadhesion test with cerebral antigens visualized by means of latex particles. The healthy children and those with encephalopathies manifested significant differences in the test as well as correspondence of the test values with the gravity of the clinical manifestations of CNS pathology. It has been noted that the mother's health status influenced the test values in neonates with encephalopathies.

Attention Deficit Disorder with Hyperactivity↗
PubMed1990

[Sensitization of lymphocytes from newborn infants and young children to pathogenic and opportunistic microflora].

The nucleolar test was used to study sensitization of peripheral blood lymphocytes from the newborn and infants. The test is based on the counting of cells with a clarification area around nucleoli after incubation with antigens and microbial bodies of the pathogenic and opportunistic microflora. It has been established that the peripheral blood from children with infectious-inflammatory diseases and from those vaccinated with BCG shows an increase in the sensitized lymphocyte count which is influenced by child's trophicity at birth and by administration of antibacterial therapy. The use of the nucleolar test as a diagnostic aid is advisable to identify the disease etiology.

Age Factors↗
PubMed1989

[Differential microcalorimetry of the antigen-antibody reaction].

High sensitivity of the microcalorimetric method for the registration of immunologic reactions and prospects of the practical application of the method demand an objective interpretation of the results and an explanation of the range of thermistometry findings varying from positive to negative values. The investigations have been carried out with models with known titers of purified antigens and antibodies and with unknown antibody titers. The method has been employed in examinations of children suffering from infectious allergic diseases and from central nervous system abnormalities. The energy processes connected with the negative, zero, or positive results of the reactions, depending on the antibody and antigen concentrations, are explained.

Antigen-Antibody Reactions↗
PubMed1989

[Morphologic changes of the nucleolar system of lymphocytes as the indicator of sensitivity to tuberculin and Toxoplasma antigen].

A study was made of the nucleolar apparatus of peripheral blood lymphocytes of the newborns, infants and their mothers before and after incubation in vitro with tuberculin or toxoplasmic antigen. It was established that in the presence of sensitization to one or another antigen, there was an increase in the relative count of lymphocytes having a zone of clarification near nucleoli. In children vaccinated with BCG, such an effect was noted in 81.3% of the cases, whereas in children with verified toxoplasmosis, in all the cases. It is recommended that the method designed might be used as alternative for the complement fixation test in the diagnosis of toxoplasmosis.

Animals↗