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Biomedical subjects

A Husain

Publications and source records attributed to A Husain.

At least 145 records · Page 8Linked to original sources
PubMed1983

The effect of cross-linking spectrin-actin complexes with band 4.1 on the state of polymerization of the actin.

The polymerization of actin in the presence of spectrin tetramers and band 4.1 isolated from the human erythrocyte has been measured using a fluorescence energy transfer technique. The results show that the cross-linking of spectrin-actin complexes by band 4.1 results in a limited depolymerization of actin filaments and a concomitant rise in the critical actin concentration. The phenomenon may explain in part the existence of actin in the erythrocyte cytoskeleton as short oligomers rather than as long filaments.

Actins↗
PubMed1983

Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.

A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.

Angiotensin I↗
PubMed1983

History of incest in girls admitted to a psychiatric hospital.

Of 437 adolescent girls admitted to a psychiatric hospital for emotional problems, 61 reported an incestuous involvement. Their mean age at the time of their first experience was 11.9 years. The liaisons occurred as often with fathers as with stepfathers; other, less frequent perpetrators of incest included brothers, brothers-in-law, uncles, a grandfather, an adoptive father, and a half-brother. The authors note that the victim of incest is almost always a preadolescent and that the occurrence of incest is probably not accurately reported nationally.

Adolescent↗
PubMed1983

A study of young-age and mid-life homicidal women admitted to a psychiatric hospital for pre-trial evaluation.

The authors compared a group of young female homicidal offenders with a group of middle-aged homicidal women as to demographic data, psychopathology, physical disorders and type of victims chosen. Young women tend to have low socioeconomic status, have antisocial personality disorder, and/or schizophrenia as psychiatric diagnoses and most likely kill their children, while mid-life women tend to have slightly higher socioeconomic status, suffer from affective disorder and alcoholism and have more frequent physical disorders and most likely murder their spouses. A significant finding noted among mid-life women is the high frequency of physical abuse by husbands who later become their homicide victims. Treatment implications of these findings are noted.

Adult↗
PubMed1982

Studies on Claviceps parasitic on Panicum species in India.

Panicum repens and P. antidotale were found to be infected with Claviceps sp. This is the first report of ergot on P. repens. The pyrenomycete produced abundant sclerotia on the host plants. The sclerotia contained 0.71 and 0.68% alkaloids, respectively, which predominantly consisted of chanoclavine, festuclavine and agroclavine. The infected grasses were possibly mycotoxic. Submerged cultures of Claviceps strain isolated from Panicum spp. produced significant amount of chanoclavine, festuclavine and agroclavine. No pharmaceutically important alkaloid was found in sclerotia or in submerged culture.

Claviceps↗
PubMed1981

Brain renin: localization in rat brain synaptosomal fractions.

The distribution of brain renin activity was determined in subcellular fractions of rat brain prepared by discontinuous density gradient centrifugation. The highest amounts of brain renin activity occurred in both the light and heavy synaptosomal fractions, while the activity of choline acetyltransferase was elevated only in the light synaptosomal fraction. These results indicate an intraneuronal localization of brain renin.

Animals↗
PubMed1981

Current perspectives on childhood depression: an overview.

The rapidly increasing research interest in childhood depression indicates that it has become a recognized disorder. The authors review the literature on depression in children, focusing on epidemiology, various diagnostic criteria, classification schemes, assessment instruments, and intervention studies that have been applied to childhood depression. Given that there are many etiological factors, it will be important to study the disorder from various conceptual frameworks, including biochemical, genetic learned helplessness, life stresses, cognitive distortion, behavioral reinforcement, and sociological models.

Child↗
PubMed1980

A simple microassay for the estimation of renin concentration in plasma.

A simple assay for the measurement of renin concentration and renin substrate concentration in microliter quantities of rat plasma is described. In the plasma renin concentration assay 5 microliter of rat plasma was incubated for 2 hr at 37 degrees C in the presence of 20 microliter renin substrate (plasma from nephrectomized rats) and 5 microliter inhibitor-buffer solution pH 7.4. At the end of the enzymic incubation the generated angiotensin I was estimated by radioimmunoassay. Angiotensin I antisera and iodinated angiotensin I were added to the same tube and left to equilibrate at 45 degrees C for 15 hr. EDTA, dimercaprol, and 8-hydroxyquinoline were used to inhibit converting enzymes and angiotensinases. Reproducibility of the assay was good, and recovery of added angiotensin I complete. The normal range of plasma renin in rats was between 7 and 15 pmol angiotensin l/ml/hr.

Angiotensin I↗
PubMed1980

Methylphenidate, neuroleptics and dyskinesia-dystonia.

Methlyphenidate is one of two stimulant drugs used in the management of the Hyperkinetic Reaction in children. It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine was followed by withdrawal of the phenothiazine. It is postulated that the use of phenothiazine resulted in a post-synaptic supersensitivity which precipitated dystonia and dyskinesia when phenothiazine was withdrawn and methylphenidate reinstituted. It is also suggested that the phenothiazine dopamine-blocking action may necessitate the use of larger quantities of stimulant in order to produce the desired effect.

Asthma↗
PubMed1979

Preparation of cupric palmitate membrane, its characterization and evaluation of thermodynamically effective fixed charge density.

Membrane potentials have been measured across parchment-supported cupric palmitate membrane separating various 1:1 electrolytes at concentrations C1 and C2 such that C2 = 10 C1. Membrane potential data have been used to calculate transference number of ions, permselectivity and also to derive the thermodynamically effective fixed charge density which is an important characteristic governing the membrane phenomena by utilizing the generally accepted and most widely used theory of Teorell-Meyer and Sievers as well as the recent theories for membrane potential of Kobatake et al. and Nagasawa et al. based on the principles of nonequilibrium thermodynamics. The values of charge densities derived from different theories were almost the same, confirming thereby the validity of the recently developed theories of membrane potential.

Electrochemistry↗