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Biomedical subjects

A Hunter

Publications and source records attributed to A Hunter.

At least 127 records · Page 7Linked to original sources

The effects of three differing anaesthetics on the immune response.

A clinical study was undertaken to investigate changes in the immune response in patients undergoing three differing anaesthetic techniques for inguinal hernia repair. No significant differences between anaesthetic groups were demonstrated in the haematological parameters. The value of mitogen stimulation tests was questioned in the clinical setting. The migratory component of neutrophil function was shown to be preserved following conduction anaesthesia compared to the other anaesthetic groups and its possible advantage noted.

Adult↗

Craniosynostosis.

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Craniosynostoses↗

46,XX/46XY chromosome complement in amniotic fluid cell culture followed by the birth of a normal female child.

Experience indicates that the most likely explanation for a mixture of 46,XX/46,XY cells in an amniotic fluid sample is that of maternal cell contamination and that a normal male child is to be expected at birth. We report the bith of a normal female child following prenatal diagnosis of such a mixture. Extensive postnatal studies failed to reveal an XY cell line. The possible sources of the XY cell line are discussed, as are the various techniques that were applied in an effort to discover it's origin. Cross-contamination of samples could be ruled out and there was no evidence of an unsuspected twin pregnancy. It is clear from this case that not all 46,XX/46,XY results obtained in amniotic fluid can be assumed to represent maternal cell contamination and some effort should be made to eliminate other potential sources for such a mixture.

Adult↗

Cytogenetic findings in Roberts-SC phocomelia syndrome(s).

Roberts syndrome and SC phocomelia syndrome are an autosomal recessive condition of prenatal and postnatal growth retardation, symmetrical limb reduction, and craniofacial abnormalities. A distinction has been made between the two syndromes on the basis of relative severity of these manifestations. Where chromosome studies have been carried out, most have been reported as normal. However, there have been two reports of consistent centromere abnormalities; one in a patient with SC phocomelia (pseudothalidomide syndrome), the other in a patient with Roberts syndrome. Four patients with similar phenotypic manifestations have recently been shown in our laboratory to have the same centromere puffing and splitting. These four patients had other clinical manifestations in common, including bilateral corneal opacities, microcephaly, absence of radii, limited extension at knees and elbows, apparent enlargement of the phallus, and survival beyond the neonatal period.

Abnormalities, Multiple↗

Alice Mary Bush.

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History, 20th Century↗