Biomedical subjects

A Hotze

Publications and source records attributed to A Hotze.

41 records · Page 3Linked to original sources

PubMed1984

[Combined bone marrow and skeletal scintigraphy in osseous and myelogenous diseases].

In 87 patients with proved diagnosis and a normal or pathologic bone scan (BS) in addition a bone marrow scan (BMS) was performed using a 99mtechnetium-labelled microcolloid. The analysis of scintigraphic findings included those obtained by other investigations shows that in these selected patients a false normal or false positive interpretation would have been resulted in 18% performing the BS only. Both methods BS and BMS were capable of diagnosing the correct stage of disease in all patients. The results indicate an augmentation of diagnostic facilities by the BMS in diseases affecting bone or bone marrow.

Adult↗

PubMed1984

[Results of scintigraphic studies with 131I-meta-benzylguanidine in space-occupying lesions of neuroectodermal origin].

Between 1982 and 1984, 48 studies with 131I-meta-benzylguanidine were carried out in Erlangen in patients with suspected pheochromocytoma or neuroblastoma. Scintigraphy with MIBG was found to be highly specific. False positive findings can be avoided if with weak uptakes an exact correlation with the results of morphological studies such as CT or sonography is sought and if follow-up observations ensure that they are not caused by activity residues in the biliary, intestinal or urinary pathways. False negative findings are made in 5-10% of the investigations in pheochromocytoma and in 41% of those in neuroblastoma patients. In pheochromocytoma the uptake rates are generally low (1-2%), whereas in neuroblastoma they may reach 10% and more.

3-Iodobenzylguanidine↗

PubMed1983

Increased serum concentration of free L-triiodothyronine in patients treated with L-thyroxine.

This study demonstrates that in spite of measured normal concentrations of carrier proteins one cannot deduce in all cases a normal fT3 from a normal level of TT3 when l-thyroxine given for diagnostic or therapeutic purposes is present in excess. The displacement of l-triiodothyronine from its binding sites is shown in 35 patients with non-toxic goitre who received an oral dose of 200 micrograms l-thyroxine/die for two weeks. Apart from a significant increase of TT4 (from 7.85 to 14.21 micrograms/dl equal + 81%) and of fT4 (from 1.58 to 3.7 ng/dl equal + 134%) there is only a slight increase in TT3 from 148 to 158 ng/dl (equal + 10%) after 14 days of treatment. By contrast fT3 rises clearly from 4.97 to 8.07 pg/ml equal + 63% (normal range: 2.8-5.6 pg/ml). Compared with the increase of TT3 (+ 10%) the free T3 rises by a factor of 6.3 (63%/10%). On account of higher affinity of l-thyroxine to binding proteins the free T4 is influenced to a lesser degree. Compared with the increase of TT4 (+ 81%) free T4 rises by a factor of 1.6 (134%/81%). It is supposed that the serum concentration of free T3 can be increased despite a normal concentration of TT3 when l-thyroxine is present in excess. Therefore, for laboratory work fT3 should be assigned a higher validity than TT3 when patients are treated with comparatively high doses of l-thyroxine.

Adult↗

PubMedDate not supplied

[Scintigraphic panoramic imaging of the jaws].

A method for the generation of a panoramic image from skeletal scintiscans of the jaws with the aid of a cylindrical projection of emission CT scans ist presented. Based on this "panoramic tomoscintigraphy" the jaw regions, arranged in the order of the arch segments, are evaluated numerically and the quantitative results are presented in a clearly organized form. The relative activity of each segment is computed relative to the corresponding contraletaral segment or to the average activity of the respective jaw. In the case of pathologic findings the respective segments are highlighted in the dental chart. A set of normal values with standard deviations has been generated using this method in 24 patients without evidence of any jaw pathology. Within the framework of the significance limit it was not possible to demonstrate any right/left asymmetry in the metabolic activities of the jaw bone.

Adolescent↗

PubMedDate not supplied

Extracardiac intrathoracic abnormalities demonstrated by Tc-99m RBC gated blood pool imaging.

In addition to intrathoracic great vessel abnormality, pericardial effusion, and splenomegaly, extracardiac intrathoracic abnormalities were found in 12 of 210 patients' 99mTc red blood cell (RBC) gated cardiac blood pool imagings. These abnormalities, including five cases of absent pulmonary perfusion due to tumor mass, four of pleural effusion, two of pneumothorax, and one of left lung mass attenuation, were confirmed with concurrent or subsequent chest radiography, chest CTs, or biopsy. Pulmonary blood pool activity is normally seen on both sides in both anterior and left anterior oblique views; decreased or absent perfusion on either side or in part of the lung may indicate chest/pulmonary pathologies. Although pulmonary and thoracic wall lesions are not frequently seen, such incidental findings during gated cardiac blood pool imagings can lead to further study for these clinically unsuspected lesions and may benefit the patient.

Aged↗